Large B Cell Lymphoma (DBCOND0030939)

Identifiers

Synonyms
Large B-cell Lymphoma

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Glofitamab
A bispecific monoclonal antibody directed against CD20 and CD3 which is used for the treatment of relapsed or refractory diffuse large B-cell lymphoma.
Polatuzumab vedotin
A CD79b antibody conjugate indicated to treat different types of large B-cell lymphoma.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05940272
Study of a Communication Training Intervention for Large B-Cell Lymphoma ProvidersNo drug interventionsotherNot Availablerecruiting
NCT06356129
Study to Compare the Effectiveness and Safety of Golcadomide Plus R-CHOP vs Placebo Plus R-CHOP in Participants With Previously Untreated High-risk Large B-cell Lymphomatreatment3recruiting
NCT06610344
BHB & CAR-T for LymphomasNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03960840
Phase I/II Study of Rapcabtagene Autoleucel in CLL, 3L+ DLBCL, r/r ALL and 1L HR LBCLtreatment1 / 2recruiting
NCT05887167
Feasibility and Safety of Collecting and Combining Autologous Hematopoietic Stem Cells with Chimeric Antigen Receptor (CAR) T-Cell Therapy in Subjects with Relapsed/Refractory Hematological MalignanciesNo drug interventionstreatment1recruiting
NCT06500273
Consolidation of First-Line MRD+ Remission with Cema-cel in Patients with LBCLtreatment2recruiting
NCT05794958
Evaluate Safety of Axicabtagene Ciloleucel Reinfusion (Axi-Cel-2) in Patients With Relapsed and/or Refractory Second Line High-Risk Non-Hodgkin Lymphoma After Standard of Care Axi-Celtreatment1recruiting
NCT06047080
An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphomatreatment3recruiting
NCT06285422
Study Evaluating SC262 in Subjects with R/r Non-Hodgkin's Lymphoma (VIVID)treatment1recruiting
NCT06544265
SynKIR-310 for Relapsed/Refractory B-NHLNo drug interventionstreatment1recruiting
NCT06593145
CAR T Cells in the Treatment of Refractory and Relapsed CD19+ B Cell NeoplasmsNo drug interventionstreatment1recruiting
NCT06486051
A Study of WZTL-002 CAR T-cells for Adults With Relapsed Large B-cell Lymphomatreatment2recruiting
NCT05108805
Chimeric Antigen Receptor (CAR) T Cell Therapy With YESCARTA in the Outpatient SettingNo drug interventionssupportive_careNot Availableactive_not_recruiting
NCT06071871
A Trial of Polatuzumab Vedotin, Obinutuzumab and Glofitamab as a Peri-CAR-T Cell Treatment Strategy in Large B-cell Lymphomatreatment2recruiting
NCT05020678
NKX019, Intravenous Allogeneic Chimeric Antigen Receptor Natural Killer Cells (CAR NK), in Adults With B-cell CancersNo drug interventionstreatment1recruiting
NCT05643742
A Safety and Efficacy Study Evaluating CTX112 in Subjects With Relapsed or Refractory B-Cell MalignanciesNo drug interventionstreatment1 / 2recruiting
NCT05648019
CD19-Directed Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory B-Lineage Leukaemia / Lymphoma - A Feasibility ProtocolNo drug interventionstreatment2recruiting
NCT05820841
Acalabrutinib in Combination With R-miniCHOP in Older Adults With Untreated Diffuse Large B-Cell Lymphomatreatment3recruiting
NCT06550141
Emapalumab Prevention of CAR-T Cell Associated Toxicitiestreatment2not_yet_recruiting
NCT06567366
CAR T-cell Therapy in Combination With Glofitamab for Relapsed/Refractory Large B-Cell Lymphoma With High-Risk Prognostic Factorstreatment2not_yet_recruiting
NCT05665062
Autologous CD19 CAR-T Cell Therapy (SYNCAR-001) + Orthogonal IL-2 (STK-009) in Subjects With CD19+ Hematologic Malignanciestreatment1recruiting
NCT04690192
CNCT19 Following ASCT in Patients With Relapsed or Refractory B-cell Lymphomatreatment1 / 2active_not_recruiting
NCT06104592
Single-Arm Comprehensive Ablative Bridging Irradiation I Prior to CD19 CAR-T In High-Risk R/R LBCLNo drug interventionstreatment2recruiting
NCT05429268
Study to Evaluate the Safety and Efficacy of Tafasitamab Plus Lenalidomide in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (firmMIND)treatment3recruiting
NCT05472610
Study of Efficacy of BZ019 in Large B-cell LymphomaNo drug interventionstreatment2unknown_status
NCT04503538
Telemedicine for Early Detection of Cytokine Release Syndrome and NeurotoxicityNo drug interventionssupportive_careNot Availablewithdrawn
NCT06564038
A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignanciestreatment1 / 2not_yet_recruiting
NCT06375733
A Study of GFH009 in Combination With Zanubrutinib in Subjects With Relapsed or Refractory DLBCLtreatment1 / 2recruiting
NCT06045247
Phase 2 Trial of Epcoritamab in Combination With Rituximab-mini CVP for Older Unfit/Frail Patients or Anthracycline-Ineligible Adult Patients With Newly Diagnosed Diffuse Large B-cell Lymphomatreatment2recruiting
NCT06343311
T-Cell Therapy (EB103) in Adults With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (NHL)No drug interventionstreatment1 / 2recruiting
NCT04566978
89Zr-DFO-REGN3767 in PET Scans in People With Diffuse Large B Cell Lymphoma (DLBCL)diagnostic0active_not_recruiting
NCT06142188
Relmacabtagene Autoleucel in Hematologic MalignanciesNot AvailableNot Availablenot_yet_recruiting
NCT05377307
Long-term Follow-up Study of Lentiviral-based Gene-edited Immune Cell TherapyNo drug interventionsNot AvailableNot Availablerecruiting
NCT06479356
CD19-targeted CAR T Cells for Relapsed or Refractory (R/R) Large B-cell Lymphomatreatment2recruiting
NCT06167785
A Study to Evaluate Zanubrutinib and Tislelizumab in Progressive Lymphoma Post CAR-Ttreatment2not_yet_recruiting
NCT05757700
Study of 19(T2)28z1xx TRAC-Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell LymphomaNo drug interventionstreatment1recruiting
NCT06142175
Relmacabtagene Autoleucel in Patients With LBCLNot AvailableNot Availablerecruiting
NCT05464719
A Phase II Study of Loncastuximab Tesirine as Consolidation Strategy in Patients With LBCL in PR After CAR T-cell Therapytreatment2recruiting
NCT04250324
Study of Safety and Efficacy of BZ019 in (R/R) Large B-cell LymphomaNo drug interventionstreatment1unknown_status
NCT04889716
CAR-T Followed by Bispecific Antibodiestreatment2recruiting
NCT05929716
An Open-Label, Single Center Phase 2 Study of Magrolimab, Rituximab and Radiation as Bridging Strategy Before CAR T-Cell Therapy in Patients With Relapsed or Refractory Large B-cell Lymphomatreatment2withdrawn
NCT05404048
PD-L1 PET-imaging During CAR T-cell TherapyNo drug interventionsdiagnostic2recruiting
NCT03642626
MT2017-45: CAR-T Cell Therapy for Heme MalignanciesNot AvailableNot Availableactive_not_recruiting
NCT05776160
Expanded Access Study for the Treatment of Patients With Commercially Out-of-Specification Axicabtagene CiloleucelNot AvailableNot Availableavailable
NCT06567080
JWCAR201 for the Treatment of Hematology Malignancy and Autoimmune DiseasesNo drug interventionstreatment1not_yet_recruiting
NCT05733650
Expanded Access Program for EpcoritamabNot AvailableNot Availableapproved_for_marketing
NCT05326243
Phase 1/2 Study of CD19 Chimeric Antigen Receptor T-cell (CD19 CAR-T; PL001) for Relapsed or Refractory B-cell LymphomaNo drug interventionstreatment1 / 2recruiting
NCT03188198
Risk Adapted Therapy in Diffuse Large B Cell Lymphomatreatment2unknown_status
NCT00118209
Rituximab and Combination Chemotherapy in Treating Patients With Diffuse Large B-Cell Non-Hodgkin's Lymphomatreatment3completed