Secondary Myelofibrosis (DBCOND0030964)

Identifiers

Synonyms

SMF / Secondary myelofibrosis / Myelofibrosis / Myelofibrosis due to another disorder (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Fedratinib	Fedratinib is indicated for the treatment of adult patients with intermediate-2 or high-risk primary or secondary (post-polycythemia vera or post-essential thrombocythemia) myelofibrosis.[L8090,L47016]	ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter POU domain, class 2, transcription factor 2transporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Flavin-containing monooxygenase 3enzyme Tyrosine-protein kinase JAK2target Receptor-type tyrosine-protein kinase FLT3target Tyrosine-protein kinase JAK1target Cytochrome P450 2D6enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00589602	T-Cell Depletion, Donor Hematopoietic Stem Cell Transplant (HSCT), and T-Cell Infusions in Treating Patients With Hematologic Cancer or Other Diseases	No drug interventions	treatment	2	terminated
NCT00095784	Decitabine in Treating Patients With Myelofibrosis	Decitabine	treatment	2	active_not_recruiting
NCT01731951	Imetelstat Sodium in Treating Participants With Primary or Secondary Myelofibrosis	Grn163l Imetelstat	treatment	2	completed
NCT00381693	Azacitidine in Treating Patients With Myelofibrosis	Azacitidine	treatment	2	terminated
NCT00669578	CC-4047 in Treating Patients With Myelofibrosis	Pomalidomide	treatment	1 / 2	completed
NCT00376519	Umbilical Cord Blood T-Regulatory Cell Infusion Followed by Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Leukemia or Other Hematologic Diseases	Cyclophosphamide Cyclosporine Fludarabine Mycophenolate mofetil	treatment	1	terminated
NCT02917096	Ruxolitinib Phosphate and Chemotherapy Given Before and After Reduced Intensity Donor Stem Cell Transplant in Treating Patients With Myelofibrosis	Fludarabine Mechlorethamine Ruxolitinib Sirolimus Tacrolimus	treatment	1	completed
NCT00438958	Sibling Donor Peripheral Stem Cell Transplant or Sibling Donor Bone Marrow Transplant in Treating Patients With Hematologic Cancers or Other Diseases	Filgrastim	treatment	3	completed
NCT00589563	Sirolimus, Tacrolimus, and Antithymocyte Globulin in Preventing Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant For Hematological Cancer	Cyclophosphamide Etoposide Fludarabine Melphalan Methotrexate Sirolimus Tacrolimus	supportive_care	2	completed
NCT01093586	Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies	Antilymphocyte immunoglobulin (horse) Antithymocyte immunoglobulin (rabbit) Busulfan Cyclophosphamide Cyclosporine Methylprednisolone Methylprednisolone hemisuccinate Mycophenolate mofetil	treatment	2	completed
NCT00423826	Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other Disease	Busulfan Cytarabine Fludarabine Mycophenolate mofetil Tacrolimus	Not Available	Not Available	no_longer_available
NCT05393674	Fedratinib in Combination With Nivolumab	Fedratinib Nivolumab	treatment	2	recruiting
NCT01529827	Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies	Fludarabine Melphalan Methotrexate Mycophenolate mofetil Tacrolimus	treatment	2	completed
NCT01199562	Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant	Foscarnet Ganciclovir Valganciclovir	Not Available	Not Available	completed
NCT05364762	Adding Itacitinib to Cyclophosphamide and Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Hematopoietic Stem Cell Transplants	Cyclophosphamide Itacitinib Tacrolimus	prevention	2	recruiting
NCT03118492	Combination Chemotherapy, Total Body Irradiation, and Donor Blood Stem Cell Transplant in Treating Patients With Secondary Myelofibrosis	AVI-014 Cyclophosphamide Filgrastim Fludarabine Mechlorethamine Mycophenolate mofetil Tacrolimus	treatment	1	recruiting
NCT00445744	Cyclophosphamide and Busulfan Followed by Donor Stem Cell Transplant in Treating Patients With Myelofibrosis, Acute Myeloid Leukemia, or Myelodysplastic Syndrome	Busulfan Cyclophosphamide Methotrexate Tacrolimus	treatment	Not Available	completed
NCT04339101	Itacitinib, Tacrolimus, and Sirolimus for the Prevention of GVHD in Patients With Acute Leukemia, Myelodysplastic Syndrome, or Myelofibrosis Undergoing Reduced Intensity Conditioning Donor Stem Cell Transplantation	Fludarabine Itacitinib Mechlorethamine Sirolimus Tacrolimus	treatment	2	active_not_recruiting
NCT03426969	Combination Chemotherapy, Total Body Irradiation, and Donor Blood Stem Cell Transplant in Treating Patients With Primary or Secondary Myelofibrosis	Cyclophosphamide Filgrastim Fludarabine Mechlorethamine Mycophenolate mofetil Tacrolimus	treatment	0	completed
NCT03303950	Allogeneic Stem Cell Transplantation for Multiple Myeloma and Myelofibrosis	Busulfan Cyclophosphamide Fludarabine	treatment	2	terminated
NCT02251821	JAK Inhibitor Before Donor Stem Cell Transplant in Treating Patients With Primary or Secondary Myelofibrosis	Busulfan Cyclophosphamide Fludarabine Mechlorethamine Methopterin Methotrexate Mycophenolate mofetil Ruxolitinib Tacrolimus	treatment	2	active_not_recruiting
NCT04282187	Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms	Decitabine Fedratinib Pacritinib Ruxolitinib	treatment	2	recruiting
NCT00722254	Reversible Secondary Myelofibrosis or Clonal Myeloproliferative Disorder	No drug interventions	Not Available	Not Available	terminated
NCT00611351	Busulfan, Cyclophosphamide, & Antithymocyte Globulin Followed by Stem Cell Transplant in Treating Hematologic Cancer	Busulfan Cyclophosphamide Mycophenolate mofetil Tacrolimus	treatment	2	completed
NCT02528877	Ruxolitinib Phosphate, Tacrolimus and Sirolimus in Preventing Acute Graft-versus-Host Disease During Reduced Intensity Donor Hematopoietic Cell Transplant in Patients With Myelofibrosis	Fludarabine Mechlorethamine Ruxolitinib Sirolimus Tacrolimus	supportive_care	1	withdrawn
NCT01732445	Ruxolitinib Phosphate and Danazol in Treating Anemia in Patients With Myelofibrosis	Danazol Ruxolitinib	supportive_care	2	completed
NCT02098161	LCL161 in Treating Patients With Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocytosis Myelofibrosis	LCL-161	treatment	2	completed
NCT00445900	Thalidomide, Prednisone, and Cyclophosphamide in Treating Patients With Myelofibrosis and Myeloid Metaplasia	Cyclophosphamide Prednisone Thalidomide	treatment	2	completed
NCT00424242	Pemetrexed Disodium in the Cerebrospinal Fluid of Patients With Leptomeningeal Metastases	Pemetrexed	treatment	0	completed
NCT06516406	Ruxolitinib in Primary Myelofibrosis and Secondary to Essential Thrombocythemia or Polycythemia Vera	No drug interventions	Not Available	Not Available	recruiting
NCT01273766	Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies	Deferasirox	supportive_care	2	completed
NCT00630994	Low-Dose Decitabine in Treating Patients With Symptomatic Myelofibrosis	Decitabine	treatment	2	terminated
NCT02370329	P1101 in Treating Patients With Myelofibrosis	Benzalkonium Interferon alfa Proline Ropeginterferon alfa-2b	treatment	2	active_not_recruiting
NCT04384692	Peritransplant Ruxolitinib for Patients With Primary and Secondary Myelofibrosis	Busulfan Cyclophosphamide Fludarabine Mechlorethamine Methopterin Methotrexate Mycophenolate mofetil Ruxolitinib Tacrolimus	treatment	2	recruiting
NCT04370301	Reduced Intensity Haploidentical Transplantation for the Treatment of Primary or Secondary Myelofibrosis	Cyclophosphamide Fedratinib Filgrastim Fludarabine Mechlorethamine Mycophenolate mofetil Ruxolitinib Tacrolimus	treatment	2	recruiting
NCT03195010	Management of Platelet Transfusion Therapy in Patients With Blood Cancer or Treatment-Induced Thrombocytopenia	No drug interventions	supportive_care	2	terminated
NCT01644110	Ruxolitinib and Pomalidomide Combination Therapy in Patients With Primary and Secondary MF	Pomalidomide Ruxolitinib	treatment	1 / 2	active_not_recruiting