Angioneurotic Edema (DBCOND0031400)

Identifiers

Synonyms

Angioneurotic oedema / Angioneurotic edema / Allergic angioedema / Allergic angioedema (disorder) / Angioedema (morphologic abnormality) / Oedema angioneurotic / Quincke's edema / Angioedema / Angioedema (disorder) / Angioedemas / Edema angioneurotic / Angioedema and urticaria / Angio-edema / Oedema Quincke's / Quincke's oedema / Giant urticaria / Edema Quincke's / Urticaria giant / Giant urticaria (disorder) / Giant hives / Hives giant

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Chlorpheniramine	A histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies.	Histamine H1 receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme Sodium-dependent serotonin transportertarget Sodium-dependent noradrenaline transportertarget Sodium-dependent dopamine transportertarget Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter
Epinephrine	A hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma.	Alpha-1A adrenergic receptortarget Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Alpha-1B adrenergic receptortarget Alpha-1D adrenergic receptortarget Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Tumor necrosis factortarget Catechol O-methyltransferaseenzyme Monoamine oxidaseenzyme
Hydrocortisone phosphate	A corticosteroid used to treat congenital adrenal hyperplasia, for emergency asthma treatment, hypersensitivity, and inflammation.	Annexin A1target Glucocorticoid receptortarget Sex hormone-binding globulincarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 2C8enzyme Corticosteroid-binding globulincarrier 11-beta-hydroxysteroid dehydrogenase type 2target 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target Organic anion transporter 3transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00517582	Bradykinin Receptor Blocker in ACE Inhibitor-associated Angioedema	Icatibant	treatment	1	terminated
NCT00225147	Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema	Conestat alfa	treatment	2 / 3	completed
NCT00119431	Kinetics, Efficacy and Safety of C1-Esteraseremmer-N	Human C1-esterase inhibitor	prevention	2	completed
NCT00262301	Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema	Conestat alfa	treatment	3	completed