Posterior Uveitis (DBCOND0032106)

Identifiers

Synonyms

Uveitis Affecting the Posterior Segment / Posterior segment uveitis / Diffuse posterior uveitis / Uveitis, Posterior / Posterior uveitis / Posterior uveitis (disorder) / Unspecified chorioretinal inflammation / Chorioretinal inflammation / Chorioretinitis / Chorioretinitis (disorder) / Chorioretinitis, unspecified

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Hydrocortisone	A glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders.	Annexin A1target Glucocorticoid receptortarget Sex hormone-binding globulincarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 11B2, mitochondrialenzyme Cytochrome P450 2C8enzyme Corticosteroid-binding globulincarrier Organic anion transporter 3transporter Aldo-keto reductase family 1 member D1enzyme 3-oxo-5-alpha-steroid 4-dehydrogenase 2enzyme 11-beta-hydroxysteroid dehydrogenase type 2enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme
Prednisolone	A glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.	Corticosteroid-binding globulincarrier Cytochrome P450 3A4enzyme Glucocorticoid receptortarget Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Albumincarrier
Prednisone	A corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Cytochrome P450 2C19enzyme Albumincarrier Cytochrome P450 3A5enzyme Corticosteroid-binding globulincarrier Cytochrome P450 3A Subfamilyenzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01781936	Pilot Study of a Fluocinolone Acetonide Intravitreal Insert (FA-i) to Treat Intermediate-, Posterior-, or Panuveitis	Fluocinolone acetonide	treatment	1	completed
NCT03971279	Dexamethasone Intravitreal Implant (Ozurdex®) for Recurrent Vogt-Koyanagi-Harada (VKH) Disease Posterior Uveitis	Dexamethasone	Not Available	Not Available	completed
NCT00167583	Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet's Disease (INCYTOB)	Cyclosporine Interferon alfa	treatment	3	completed
NCT00615693	Safety, Tolerability, and Efficacy of AEB071 in the Treatment of Uveitis	Sotrastaurin	treatment	2	completed
NCT00407316	Quality of Life and Visual Function in Uveitis Patients	No drug interventions	Not Available	Not Available	unknown_status
NCT00570830	Retisert and Cataract Surgery in Patients With Severe Uveitis	No drug interventions	treatment	Not Available	completed
NCT05153057	Birdshot Chorioretinopathy : Prospective Follow-up and Immunogenetic Studies(CO-BIRD)	No drug interventions	Not Available	Not Available	recruiting
NCT00908466	Sirolimus as Therapeutic Approach to Uveitis	Sirolimus	treatment	1	completed
NCT01789320	Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis	Triamcinolone	treatment	1 / 2	completed
NCT02746991	Safety and Efficacy Study of a FAI Insert in Subjects With Chronic Non-infectious Posterior Uveitis	Fluocinolone acetonide	treatment	3	completed
NCT02764697	Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients	Corticotropin	treatment	4	completed
NCT01717170	Study of the Safety, Tolerability, and Bioactivity of Tocilizumab On Patients With Non-infectious UVEITIS: The STOP-UVEITIS Study	Tocilizumab	treatment	1 / 2	unknown_status
NCT01280669	Intravitreal Sirolimus as Therapeutic Approach to Uveitis	Sirolimus	treatment	2	withdrawn
NCT00333814	A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Intermediate or Posterior Uveitis	Dexamethasone	treatment	2 / 3	completed
NCT04126850	Pilot Project: The Amplicon and Metatranscriptomic Study of Intra and Extra Intestinal Microbiome in Non-infectious Uveitis Disease	No drug interventions	Not Available	Not Available	unknown_status
NCT01539577	A Long-Term Safety Study of OZURDEX® in Clinical Practice	Dexamethasone	Not Available	Not Available	completed
NCT05070728	Safety and Efficacy of an Injectable Fluocinolone Acetonide Intravitreal Insert (FAI)	Fluocinolone acetonide	treatment	3	terminated
NCT03598452	High-dose Intravitreal Injection of Ganciclovir for the Treatment of CMVR in HIV-negative Patients	Ganciclovir	treatment	Not Available	completed
NCT00404742	A Study of LX211 in Clinically Quiescent Non-infectious Intermediate, Anterior and Intermediate, Posterior or Pan-Uveitis	Voclosporin	treatment	3	completed
NCT03145025	Corneal Endothelial Cell Density in Eyes Treated With a Fluocinolone Acetonide Intravitreal Implant	Fluocinolone acetonide	Not Available	Not Available	completed
NCT02125266	Safety and Preliminary Efficacy Study of V404 PDS in Uveitis	Methotrexate	treatment	1 / 2	terminated
NCT06431373	A Study of Brepocitinib in Adults With Active, Non-Infectious, Non-Anterior Uveitis	No drug interventions	treatment	3	not_yet_recruiting
NCT02049476	Study of the Effectiveness of Ozurdex for the Control of Uveitis	Dexamethasone	treatment	4	completed
NCT03066869	Efficacy and Safety of H.P. ACTHAR GEL in Adults With Retinal Vasculitis	Corticotropin	treatment	4	unknown_status
NCT00404612	A Study of LX211 in Active Sight Threatening, Non-infectious Intermediate-, Anterior and Intermediate-, Posterior-, or Pan-Uveitis	Voclosporin	treatment	3	completed
NCT00570479	Prophylactic Anecortave Acetate in Patients With a Retisert Implant	Anecortave acetate	prevention	1	completed
NCT06085079	Ixekizumab for the Management of Refractory Non-Infectious Uveitis: A Proof-of-Concept Study	Ixekizumab	treatment	4	recruiting
NCT02595398	Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis	Triamcinolone	treatment	3	completed
NCT05101928	Ozurdex Monotherapy Trial	Dexamethasone Prednisone	treatment	4	recruiting
NCT03097315	Suprachoroidal Injection of CLS-TA in Patients With Non-infectious Uveitis	Triamcinolone	treatment	3	completed
NCT02255032	Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis	No drug interventions	treatment	2	completed
NCT05322070	Fluocinolone Acetonide Intravitreal Implant 0.18 mg in the Treatment of Chronic Non-Infectious Posterior Segment Uveitis	Fluocinolone acetonide	treatment	4	active_not_recruiting
NCT00035906	Research Study in Patients With Persistent Macular Edema	No drug interventions	treatment	2	completed
NCT01905124	Safety &Efficacy of CF101 to Subjects With Uveitis	Piclidenoson	treatment	2	withdrawn
NCT03656692	Safety and Effectiveness of Acthar Gel for Inflammation of the Eye's Uvea (Middle Layer)	Corticotropin	treatment	4	terminated
NCT02952001	MAGNOLIA: Extension Study of Patients With Non-infectious Uveitis Who Participated in CLS1001-301	Triamcinolone	Not Available	Not Available	completed
NCT05486468	The Use of Two YUTIQ Versus Sham for Treatment of Chronic Non Infectious Intraocular Inflammation Affecting the Posterior Segment	Fluocinolone acetonide	treatment	3	recruiting