Photodamaged Skin (DBCOND0035543)

Identifiers

Synonyms

Photodamaged skin / Photodermatosis

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Tretinoin	A vitamin A derivative used to treat acne vulgaris and certain types of promyelocytic leukemia, as well as various skin conditions in over-the-counter medications.	Retinoic acid receptor gammatarget Retinoic acid receptor RXR-betatarget Aldehyde dehydrogenase 1A1target Retinoic acid-induced protein 3target Retinoic acid receptor RXR-gammatarget Retinal dehydrogenase 2target Retinoic acid receptor responder protein 1target Cytochrome P450 2C8enzyme Cellular retinoic acid-binding protein 1transporter Cellular retinoic acid-binding protein 2transporter Cytochrome P450 2B6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 2A6enzyme Cytochrome P450 3A7enzyme Cytochrome P450 2C18enzyme Cytochrome P450 2C9enzyme Cytochrome P450 4A11enzyme Cytochrome P450 1A1enzyme Retinoic acid receptor alphatarget Retinoic acid receptor betatarget Lipocalin-1target Odorant-binding protein 2atarget Retinol-binding protein 4target Albumincarrier [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrialtarget Retinoic acid receptor RXR-alphatarget Carcinoembryonic antigentarget UDP-glucuronosyltransferase 2B7enzyme Cytochrome P450 2E1enzyme Cytochrome P450 26A1enzyme Cellular retinoic acid-binding protein 1target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01283464	Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles	Tretinoin Vitamin A	treatment	2	completed
NCT03963102	Duration of Ameluz Application in Acral Actinic Keratoses Response	Aminolevulinic acid	treatment	4	terminated
NCT01787461	A Study to Assess the Effects of an Oral Dietary Supplement on Overall Facial Appearance Among Healthy Adult Women With Existing Skin Damage From Sun Exposure	No drug interventions	prevention	4	completed
NCT04096742	Altreno for Chest Rejuvenation	Tretinoin	treatment	4	unknown_status
NCT00375141	Long-Pulsed Dye Laser and Intense Pulsed Light for Skin Rejuvenation.	No drug interventions	Not Available	Not Available	terminated
NCT05456334	New Treatments for Actinic Keratoses of the Scalp	Methyl aminolevulinate	treatment	Not Available	active_not_recruiting
NCT06351358	Evaluation of the Effects of a Biostimulator and Dermal Fillers for Cheek Augmentation and Contour Deficiencies	No drug interventions	treatment	Not Available	recruiting
NCT03573076	Treatment of Photodamaged Skin of the décolleté	No drug interventions	treatment	4	terminated
NCT03095872	Comparison of the Effect of Vaseline and Bepanthen® "Wund- Und Heilsalbe" on the Wound Healing Following Laser Therapy	Benzalkonium Dexpanthenol	supportive_care	3	completed
NCT02693054	Safety and Efficacy Study for Various Skin Conditions	No drug interventions	other	Not Available	completed
NCT04523961	Comparative Study of Two Topical Anesthetics Prior to Fractional Nonablative Laser Treatment of the Face	Lidocaine Prilocaine Tetracaine	supportive_care	2 / 3	recruiting
NCT04065035	A Clinical Study to Evaluate Efficacy and Tolerability of a Cosmetic Product for Arm Firming	No drug interventions	treatment	Not Available	completed
NCT05908825	Placebo-Controlled Study Assessing the Use of a Novel Exfoliative Serum With A Chemical Peel to Improve Photodamage in Adults	Aloe vera leaf Ascorbic acid Glycerin Nicotinamide Vitamin A	treatment	Not Available	completed
NCT05423873	A Multi-Center, Open-label Study Evaluate the Efficacy and Tolerability of a Dual Skincare Regimen Treatment for Facial Hyperpigmentation and Photodamaged Skin in Patients Exposed to Extrinsic Factors of Aging	No drug interventions	other	Not Available	completed
NCT02736760	Daylight-PDT With MAL for AK and Photodamaged Skin	No drug interventions	treatment	4	completed
NCT05963204	A Study to Evaluate the Effects for Midface Improvement When Pairing a Biostimulator With a Skincare Regimen	Avobenzone Homosalate Meradimate Octinoxate Octisalate Octocrylene Oxybenzone Zinc oxide	treatment	Not Available	active_not_recruiting
NCT06170346	Effect of Topical Agents With Various Antioxidant Containts on Photodamage Skin Induced	No drug interventions	prevention	2	active_not_recruiting