Diabetic Peripheral Neuropathic Pain (DPN) (DBCOND0036250)

Identifiers

Synonyms

Diabetic Peripheral Neuropathic Pain / Diabetic neuropathy / Diabetic Neuropathies / Diabetes + neuropathy (& [amyotrophy]) / Diabetic neuropathy (disorder) [Ambiguous] / Diabetic neuropathy &/or diabetic polyneuropathy / Diabetes mellitus with neurological manifestation: (& [amyotrophy] or [neuropathy] or [polyneuropathy]) / Diabetes mellitus NOS with neurological manifestation (disorder) / Neuropathy due to diabetes mellitus (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Duloxetine	A serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence.	Sodium-dependent serotonin transportertarget Sodium-dependent dopamine transportertarget Sodium-dependent noradrenaline transportertarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Albumincarrier alpha1-acid glycoproteincarrier ATP-dependent translocase ABCB1transporter Cytochrome P450 3A4enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme
Pregabalin	An anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants.	Excitatory amino acid transporter 3transporter Voltage-dependent calcium channel subunit alpha-2/delta-1target Large neutral amino acids transporter small subunit 1transporter
Tapentadol	An opioid used to manage severe pain that has not responded to non-opioid medications, and for which opioid analgesic therapy is appropriate.	Mu-type opioid receptortarget Kappa-type opioid receptortarget Delta-type opioid receptortarget Sodium-dependent noradrenaline transportertarget UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B7enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Sodium-dependent serotonin transportertarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04953221	The Effect of YJ001 on Diabetic Peripheral Neuropathic Pain.	No drug interventions	Not Available	Not Available	unknown_status
NCT06546202	Real-World Pharmacological Treatment Pattern of Neuropathic Pain in China	No drug interventions	Not Available	Not Available	recruiting
NCT06203002	A Dose-ranging Study in Patients With Diabetic Peripheral Neuropathic Pain (DPNP)	No drug interventions	treatment	2	recruiting
NCT04679545	Using Cannabidiol to Treat Diabetic Peripheral Neuropathy of the Feet	Cannabidiol	treatment	2	unknown_status
NCT01364298	Efficacy and Safety of Gabapentin/B-complex Versus Pregabalin in Diabetic Peripheral Neuropathy Pain Management	Biotin Choline Cyanocobalamin Folic acid Gabapentin Inositol Nicotinamide Pantothenic acid Pregabalin Pyridoxine Riboflavin Thiamine	treatment	4	completed
NCT04688671	Efficacy and Safety of ETX-018810 for the Treatment of Diabetic Peripheral Neuropathic Pain	No drug interventions	treatment	2	completed
NCT05521737	Effect of Electroacupuncture on Sensitive Symptoms of Distal Diabetic Peripheral Neuropathy	No drug interventions	treatment	Not Available	recruiting
NCT00838799	Study of the Safety and Efficacy of RGH-896 in Patients With Diabetic Peripheral Neuropathic Pain	Pregabalin Radiprodil	treatment	2	completed
NCT02156336	Ranolazine for Diabetic Peripheral Neuropathic Pain (DPNP)	Ranolazine	treatment	4	terminated
NCT01314222	Diabetic Peripheral Neuropathic Pain (DPNP)	Pregabalin	treatment	2	completed
NCT00794430	Study of the Safety, Tolerability and Efficacy of V3381 in Patients With Diabetic Peripheral Neuropathic Pain	Indantadol Indantadol	treatment	2	completed
NCT05349357	Slider Versus Tensioner Neural Mobilization in Diabetic Peripheral Neuropathy	No drug interventions	treatment	Not Available	completed
NCT04707157	Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Diabetic Peripheral Neuropathic Pain	No drug interventions	treatment	2	terminated
NCT05292066	Efficacy of Pregabalin Vs Duloxetine in Diabetic Peripheral Neuropathic Pain at Variable Dose	Duloxetine Pregabalin	supportive_care	0	unknown_status
NCT04094662	A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled 14-week Study of DS-5565 in Chinese Patients With Diabetic Peripheral Neuropathic Pain	Mirogabalin	treatment	3	completed
NCT00071708	Duloxetine Compassionate Use in Patients Who Have Completed a Previous Neuroscience Duloxetine Clinical Trial	Duloxetine	Not Available	Not Available	no_longer_available
NCT04476108	Chronic Pain Master Protocol (CPMP): A Study of LY3016859 in Participants With Diabetic Peripheral Neuropathic Pain	Fepixnebart	treatment	2	completed
NCT06490484	Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Diabetic Peripheral Neuropathic Pain Who Had an Inadequate Response to Pregabalin	Crisugabalin Pregabalin	treatment	2	recruiting
NCT00829387	Cognitive Behavioral Therapy for Diabetic Neuropathic Pain	No drug interventions	treatment	Not Available	completed
NCT06054087	Effectiveness of Electroacupuncture in the Treatment of Diabetic Peripheral Neuropathy	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT06490445	A Study of Medical Cannabis Aerosol Via the Fixed-dose Syqe Inhaler as an Add-on Treatment of Diabetic Peripheral Neuropathic Pain (DPNP)	Medical Cannabis	treatment	2	not_yet_recruiting
NCT05895552	A Phase 2 Study of RTA 901 (BIIB143) in Participants With Diabetic Peripheral Neuropathic Pain (CYPRESS)	No drug interventions	treatment	2	recruiting
NCT05296642	Exercise Induced Hypoalgesia Diabetes	No drug interventions	diagnostic	Not Available	withdrawn
NCT02318706	DS-5565 Phase III Study for Diabetic Peripheral Neuropathic Pain	No drug interventions	treatment	3	completed
NCT03909841	Neuropathic Pain in Elderly People With Diabetes: Impact on Quality of Life and Cognition	No drug interventions	Not Available	Not Available	completed
NCT06221241	Evaluate the Efficacy and Safety of JMKX000623 in Participants With Diabetic Peripheral Neuropathic Pain	No drug interventions	treatment	2	recruiting
NCT04146896	Efficacy and Safety of NYX-2925 in Subjects With Neuropathic Pain Associated With Diabetic Peripheral Neuropathy (DPN)	No drug interventions	treatment	2	completed
NCT02417935	A Study of Duloxetine (LY248686) in Participants With Diabetic Peripheral Neuropathic Pain (DPNP)	No drug interventions	treatment	4	completed
NCT04647773	To Evaluate the Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Diabetic Peripheral Neuropathic Pain	No drug interventions	treatment	2 / 3	unknown_status
NCT05620576	A Chronic Pain Master Protocol (CPMP): A Study of LY3857210 in Participants With Diabetic Peripheral Neuropathic Pain (NP05).	No drug interventions	treatment	2	completed
NCT04833660	rTMS on Diabetic Peripheral Neuropathic Pain	No drug interventions	treatment	Not Available	unknown_status
NCT05177094	Chronic Pain Master Protocol (CPMP): A Study of LY3526318 in Participants With Diabetic Peripheral Neuropathic Pain	No drug interventions	treatment	2	completed
NCT02345291	Effect of NRD135S.E1 in Peripheral Neuropathic Pain in Diabetic Patients	No drug interventions	treatment	2	completed
NCT02607280	DS-5565 Phase III Study for Renal Impairment in Japanese Subjects	No drug interventions	treatment	3	completed
NCT05766969	Diabetic Neuropathic Pain Relief, 6 Weeks Dosage Sublingual Water-soluble CBD/PEA	No drug interventions	treatment	1 / 2	unknown_status
NCT06122012	To Evaluate the Efficacy and Safety of HSK16149 With L-carnitine in Diabetic Peripheral Neuralgia Patients in China	No drug interventions	treatment	Not Available	recruiting
NCT01429181	Efficacy & Safety Study of Nonracemic Methadone for the Relief of Chronic Peripheral Neuropathic Pain	No drug interventions	treatment	2	completed
NCT06361108	MAD Study to Assess the Safety, Tolerability, PKs and Efficacy of YJ001 for Spray Use in Patients With DPNP	No drug interventions	treatment	1	recruiting
NCT00407511	Pregabalin Treatment Of Peripheral Neuropathic Pain Associated With Diabetic Peripheral NeP (DPN), Postherpetic Neuralgia (PHN), HIV-related NeP (HIV), and Chemotherapy Induced NeP	No drug interventions	treatment	4	completed