Polymorphic Light Eruption (PLE) (DBCOND0037230)
Identifiers
- Synonyms
- Polymorphous light eruption / Polymorphic Light Eruption / Polymorphic light eruption (disorder)
Associated Data
- Indicated Drugs and Targets
Drug Description Targets Chloroquine An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis.- Tumor necrosis factortarget
- Toll-like receptor 9target
- Glutathione S-transferase A2target
- Cytochrome P450 2D6enzyme
- Cytochrome P450 3A4enzyme
- Cytochrome P450 1A1enzyme
- Cytochrome P450 2C8enzyme
- Cytochrome P450 3A5enzyme
- Glutathione S-transferasetarget
- ATP-dependent translocase ABCB1transporter
- Albumincarrier
- alpha1-acid glycoproteincarrier
- High mobility group protein B1target
- Glutathione S-transferase Mu 1target
- Angiotensin-converting enzyme 2target
- Atypical chemokine receptor 1target
- Clinical Trials
Identifier Title Drug(s) Purpose Phase Status NCT05391178 Improving Disease Severity No drug interventions health_services_research Not Available active_not_recruiting NCT00472901 Phase III Trial of CUV1647 in Polymorphic Light Eruption (PLE) Not Available Not Available completed NCT01595893 Vitamin D Supplementation in Polymorphic Light Eruption prevention 3 terminated NCT00555178 Regulatory T Cells (Tregs) in Polymorphic Light Eruption No drug interventions Not Available Not Available completed NCT00549588 Sunscreen and After-sun-lotion Protection in Polymorphic Light Eruption No drug interventions prevention Not Available completed NCT04704713 Afamelanotide in Patients Suffering From Polymorphic Light Eruption (PLE) treatment 3 completed NCT04985526 Skin Microbiome and Polymorphic Light Eruption No drug interventions prevention Not Available unknown_status NCT05320315 Protective Effect Assessment of Foto Ultra Isdin Solar Allergy Fusion Fluid on the UVA Induced PLE No drug interventions treatment Not Available completed NCT00871052 Calcipotriol and Polymorphic Light Eruption prevention Not Available completed NCT03340155 Mechanisms of Action of Photo(Chemo)Therapy in Skin Diseases No drug interventions other Not Available unknown_status