Opioid Induced Constipation (OIC)

Opioid Induced Constipation (OIC) is the indication for 5 drugs in DrugBank. It is covered by 6 curated, structured indications.

Also known as: Opioid-Induced Bowel Dysfunction · Opioid-Induced Constipation · Opioid Induced Constipation · Opioid Induced Bowel Dysfunction · Opioid-Induced Constipation (OIC)
Classified under: Chemically-Induced Disorders
Digestive System Diseases
Mental Disorders
Signs, Symptoms, and General Pathologies
Indicated drugs: Lubiprostone
Methylnaltrexone
Naldemedine
Naloxegol
Prucalopride

Resolves to

Vocabularies

MeSHM000645327ICD-10K59.0SNOMED CT139356000MedDRA10010774UMLSC0009806

What you can answer from here — as of October 23, 2026

5Indicated drugsWith each drug's targets and mechanism

Listed above

6Structured indicationsPopulation, line of therapy, route and combination as fields, not prose

78Clinical trialsPhase, status and sponsor resolved per trial

3Drugs reporting it as an adverse effectWith incidence where the label states it

Which approved drugs for Opioid Induced Constipation (OIC) share a target, and which companies have late-stage candidates against it?

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