Primary Hyperaldosteronism (DBCOND0041635)

Identifiers

Synonyms

Conns Syndrome / Conn's Syndrome / Conn Syndrome / Primary hyperaldosteronism / Idiopathic aldosteronism (disorder) / Primary hyperaldosteronism (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Canrenoic acid	An aldosterone antagonist used in primary hyperaldosteronism and other disorders related to aberrant aldosterone levels.	No drug targets
Spironolactone	An aldosterone receptor antagonist used to treat edema, hypertension, heart failure, and aldosteronism.	Mineralocorticoid receptortarget Cytochrome P450 2C8enzyme ATP-binding cassette sub-family C member 2transporter ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Cytochrome P450 11B1, mitochondrialenzyme Androgen receptortarget Progesterone receptortarget Glucocorticoid receptortarget Nuclear receptor subfamily 1 group I member 2target Bile salt export pumptransporter Albumincarrier alpha1-acid glycoproteincarrier Estrogen receptortarget Cytochrome P450 11B2, mitochondrialenzyme Voltage-dependent L-type calcium channeltarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05456997	Metabolic Myopathy in Endocrinopathy	No drug interventions	Not Available	Not Available	terminated
NCT01567111	11C-Metomidate PET Versus Adrenal Vein Sampling in Primary Aldosteronism	No drug interventions	diagnostic	Not Available	completed
NCT03474237	A Prospective Cohort Study for Patients With Adrenal Diseases	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT01978132	Primary Hyperaldosteronism and Ischemia-reperfusion Injury	No drug interventions	diagnostic	Not Available	completed
NCT02934399	Dynamic Hormone Diagnostics in Endocrine Disease	No drug interventions	Not Available	Not Available	completed
NCT04251780	Tissue K+ in Primary Hyperaldosteronism	No drug interventions	diagnostic	Not Available	recruiting
NCT05636995	HyperAldosteronism in Pregnancy Predicted Impacts (H.A.P.P.I. Trial)	No drug interventions	Not Available	Not Available	recruiting
NCT04556279	Investigating Salt Taste Threshold in Patients Being Investigated for Primary Hyperaldosteronism Before and After Treatment.	Aldosterone	Not Available	Not Available	withdrawn
NCT05640128	Determination of Threshold Values of Aldosterone in HPLC-MS/MS, of Renin and of the Aldosterone / Renin Ratio for the Diagnosis of Primary Hyperaldosteronism	No drug interventions	diagnostic	Not Available	recruiting
NCT01728493	Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment	No drug interventions	Not Available	Not Available	completed
NCT00732771	Proof-of-concept for the Aldosterone Synthase Inhibitor LCI699 in Patients With Primary Hyperaldosteronism	Osilodrostat	treatment	2	completed
NCT03155139	Primary Aldosteronism In Hypertensive Patients in China	No drug interventions	Not Available	Not Available	completed
NCT03405025	Radiofrequency Endoscopic Ablation With Ultrasound Guidance: a Non-surgical Treatment for Aldosterone-producing Adenomas	No drug interventions	other	Not Available	completed
NCT01761344	Intraoperative Analysis of Cortisol During Adrenal Vein Sampling	No drug interventions	diagnostic	Not Available	completed
NCT04278404	Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)	Abatacept Acetylsalicylic acid Aminocaproic acid Amiodarone Amphetamine Anakinra Azithromycin Bosentan Budesonide Canakinumab Cefdinir Cefepime Ceftazidime Clindamycin Clobazam Colchicine Dexamethasone Dexmedetomidine Fosfomycin Furosemide Gabapentin Guanfacine Hydrocortisone Infliximab Labetalol Lopinavir Meropenem Metformin Milrinone Nalbuphine Nicardipine Nifedipine Oseltamivir Oxycodone Remdesivir Ribavirin Risperidone Ritonavir Ruxolitinib Sarilumab Sertraline Sevelamer Spironolactone Terbutaline Tocilizumab Tranexamic acid Voriconazole Zolpidem	Not Available	Not Available	recruiting
NCT02938910	Study of Myocardial Interstitial Fibrosis in Hyperaldosteronism	No drug interventions	Not Available	Not Available	completed
NCT01959711	Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic Adrenalectomy	No drug interventions	treatment	4	completed
NCT00669266	Adrenal Tumors - Pathogenesis and Therapy	No drug interventions	Not Available	Not Available	recruiting
NCT02030587	Laparoscopic Adrenalectomy Versus Radiofrequency Ablation	No drug interventions	treatment	Not Available	unknown_status