Acute Circulatory Failure (DBCOND0046632)

Identifiers

Synonyms

Circulatory Failure / Vasodilatory shock / Shock vascular / Acute circulatory failure / Shock, unspecified / Peripheral circulatory failure / Failure peripheral circulatory / Collapse peripheral circulatory / Collapse peripheral vascular / Collapse circulatory peripheral / Shock / Shock (disorder) / Collapse cardiovascular / Circulatory collapse / Cardiovascular collapse / Collapse circulatory / Collapse vascular / Failure circulatory / Shock circulatory / Vascular collapse / Distributive shock

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Vasopressin	A peptide hormone used to increase blood pressure in patients with vasodilatory shock who are resistant to fluid and catecholamine therapy.	Vasopressin V1a receptortarget Vasopressin V2 receptortarget Vasopressin V1b receptortarget ATP-binding cassette sub-family C member 2transporter Oxytocin receptortarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01630577	Central Venous Pressure Change With Volume Challenge in Patients With Hemodynamic Instability	No drug interventions	diagnostic	3	completed
NCT05613647	Concordance Study of Therapeutic Decision-making in Patients With Shock Based on Hemodynamic Monitoring	No drug interventions	Not Available	Not Available	recruiting
NCT04337983	Hemodynamic Characteristics of Patients With SARS-CoV-2	No drug interventions	Not Available	Not Available	completed
NCT03694717	Time Course Evolution of Cardiac Output	No drug interventions	Not Available	Not Available	completed
NCT03680963	Early Versus Differed Arterial Catheterization in Critically Ill Patients With Acute Circulatory Failure:	No drug interventions	other	Not Available	completed
NCT01090791	FLOTRAC/VIGILEO in Acute Circulatory Failure	No drug interventions	Not Available	Not Available	terminated
NCT05046340	Applicability of Fluid Responsiveness Indices in Circulatory Failure (AFRIC Study) Study Project	No drug interventions	Not Available	Not Available	recruiting
NCT04360304	Assessment of Agreement Between Two Measurement Methods of Left Ventricular Outflow Tract (LVOT) Velocity Time Integral (VTI)	No drug interventions	other	Not Available	completed
NCT05032521	Treatment of Hyperlactatemia in Acute Circulatory Failure Based on Analysis of CO2: a Prospective Randomized Superiority Study (The LACTEL Study)	No drug interventions	treatment	4	completed
NCT06384287	Peripheral Tissue Perfusion in Intensive Care	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT05847998	Second Generation DICART Prototype Validation	No drug interventions	diagnostic	Not Available	completed
NCT03225378	Changes in PPV Induced by PLR Test to Predict Fluid Responsiveness in ICU	No drug interventions	Not Available	Not Available	completed
NCT04250389	Microcirculatory Effects of Methylene Blue	No drug interventions	Not Available	Not Available	completed
NCT03788772	Systems Analysis of Antigen Presenting Cells in Human Sepsis	No drug interventions	basic_science	Not Available	unknown_status
NCT02050269	Measuring the Plasma Clearance of Iohexol to Estimate Glomerular Filtration Rate in Intensive Care Unit Patients: Preliminary Feasibility Study	Iohexol	diagnostic	3	completed
NCT02878369	Evaluation of Doppler Flow From the Femoral Artery as a Reflection of Cardiac Flow in a Vascular Fluid Test	No drug interventions	Not Available	Not Available	unknown_status
NCT04946643	Subclavian Vein Diameter Variations to Assess Vascular Filling	No drug interventions	Not Available	Not Available	unknown_status
NCT03873675	Parathyroid Hormone Kinetics During CRRT	No drug interventions	Not Available	Not Available	completed
NCT03066375	Respiratory Variations For Predicting Fluid Responsiveness 2	No drug interventions	diagnostic	Not Available	completed
NCT04474249	Follow-up of Critical COVID-19 Patients	No drug interventions	Not Available	Not Available	unknown_status
NCT04526249	Evaluation of Efficacy of the Prototype RPC (Rapid Pulse Confirmation) Device in Detecting Return of Pulsatile Flow in Patients Preparing to Separate From CPB (Cardiopulmonary Bypass)	No drug interventions	Not Available	Not Available	completed
NCT03210818	Effects of Blood Flow of Venoarterial Extracorporeal Membrane Oxygenation Life Support on Microcirculation	No drug interventions	Not Available	Not Available	completed
NCT04538339	Prediction of Arterial Lactate and Blood Gas Values Through the Analysis of Central Venous Blood	No drug interventions	Not Available	Not Available	completed
NCT02083757	Fluid Responsiveness Predicted by PtcO2 in Critically Ill Patients	No drug interventions	Not Available	Not Available	completed
NCT02726776	Suspension Syndrome	No drug interventions	basic_science	Not Available	completed
NCT02051894	NeoAdapt 3: Novel Biomarkers in the Evaluation of Neonatal Circulatory Insufficiency in Babies Suffering From Hypoxic Ischemic Encephalopathy	Dobutamine	Not Available	Not Available	completed
NCT03066362	Respiratory Variations for Predicting Fluid Responsiveness	No drug interventions	diagnostic	Not Available	completed
NCT04037644	Volume Expansion With Albumin vs. Crystalloid and Expiratory Lung Impedance	No drug interventions	treatment	2 / 3	unknown_status
NCT03917446	Volume Responsiveness Assesment After Propofol.	Propofol	Not Available	Not Available	completed
NCT02974790	Diagnostic Performance of Echocardiography Performed by Emergency Physicians After a Basic Training	No drug interventions	Not Available	Not Available	terminated
NCT03814564	ASSESSment of Perfusion, Oxygen Saturation, Endothelial Function and Coagulation in Circulatory SHOCK	No drug interventions	Not Available	Not Available	completed
NCT02992002	Influence of Fluid Challenge on End-Expiratory Lung Impedance in Mechanically Ventilated Patients Monitored With Electrical Impedance Tomography	No drug interventions	Not Available	Not Available	completed
NCT01590511	Echocardiographic Prediction of Fluid Responsiveness After a Mini-fluid Challenge in Non-ventilated Patients With Shock	No drug interventions	Not Available	Not Available	completed
NCT03066388	Accuracy of Pulse Pressure Variations Measured by a Non Invasive Digital Device to Predict Fluid Responsiveness	No drug interventions	diagnostic	Not Available	terminated
NCT03622099	Small Volume Fluid Challenge as a Predictor of Fluid Responsiveness in Patients With Circulatory Failure	No drug interventions	Not Available	Not Available	completed
NCT02248025	Can Capillary Refill Time Variation During Passive Leg Raising Predict Fluid Responsiveness	No drug interventions	Not Available	Not Available	completed
NCT06285331	the Impact of Manual or Mechanical Ways to Perform PLR on the Accuracy of Evaluation of Fluid Responsiveness	No drug interventions	supportive_care	Not Available	recruiting
NCT06442267	Comparing Anticoagulation Strategies Using UFH, Argatroban and LMWH for ECMO Support	Argatroban Enoxaparin Heparin	prevention	4	recruiting
NCT02505646	Fluid Responsiveness Evaluation by AbdomiNal Compression in Kids Based on the STARLING Concept	No drug interventions	Not Available	Not Available	completed
NCT02051855	NeoAdapt 2: An Observational Study Investigating Novel Biomarkers in the Evaluation and Treatment of Neonatal Circulatory Insufficiency	No drug interventions	Not Available	Not Available	completed
NCT03378466	Heparin Anticoagulation in Septic Shock	Heparin	treatment	2	terminated
NCT03245528	Expanded Access for LJPC-501	No drug interventions	Not Available	Not Available	approved_for_marketing
NCT05824767	Serum Biomarkers to Predict Response to Angiotensin II in Septic Shock	Angiotensin II	treatment	4	recruiting
NCT06351150	Efficacy and Safety of Angiotensin II Injection Versus Placebo in Patients With Refractory Distributed Shock	Angiotensin II Sodium chloride	treatment	3	not_yet_recruiting