Chronic Hepatitis C - Genotype 3 (DBCOND0046986)

Identifiers

Synonyms

Chronic hepatitis C genotype 3 / HCV genotype 3 infection / Carrier of viral hepatitis C / Chronic hepatitis C (disorder) / Chronic viral hepatitis C / Hepatitis C, Chronic / Chronic hepatitis C

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Daclatasvir	A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents.	Nonstructural protein 5Atarget Cytochrome P450 3A5enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A43enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Genome polyproteintarget
Glecaprevir	A Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C.	Cytochrome P450 3A Subfamilyenzyme UDP-glucuronosyltransferase 1A1enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter NS3 proteasetarget Cytochrome P450 3A4enzyme Genome polyproteintarget
Pibrentasvir	A Hepatitis C NS5A inhibitor used to treat Hepatitis C.	Nonstructural protein 5Atarget Cytochrome P450 3A Subfamilyenzyme UDP-glucuronosyltransferase 1A1enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter
Sofosbuvir	A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents.	ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter RNA-dependent RNA-polymerasetarget Lysosomal protective proteinenzyme Carboxylesteraseenzyme Adenosine 5'-monophosphoramidase HINT1enzyme UMP-CMP kinaseenzyme Nucleoside diphosphate kinase Aenzyme Genome polyproteintarget
Velpatasvir	A NS5A inhibitor used to treat chronic hepatitis C infections in patients without cirrhosis or with compensated cirrhosis.	Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 3A4enzyme Nonstructural protein 5Atarget ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 2B1transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01100749	Chronic Hepatitis C (CHC) - Genotype 3 Infection in Canada	No drug interventions	Not Available	Not Available	terminated