Transthyretin Mediated Amyloidosis (ATTR) (DBCOND0047425)

Identifiers

Synonyms

Transthyretin-Mediated Amyloidosis / Transthyretin-mediated Amyloidosis (ATTR Amyloidosis) / Amyloidogenic Transthyretin (ATTR) Amyloidosis / Transthyretin (TTR)-Mediated Amyloidosis / Amyloidosis in Transthyretin (TTR) / Amyloid Transthyretin (ATTR) Amyloidosis / ATTR Amyloidosis

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Tafamidis	A medication used to treat transthyretin-mediated amyloidosis.	Transthyretintarget Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06527755	A Study to Assess the PK, PD, Safety and Tolerability of Eplontersen in Healthy Chinese Volunteers	Eplontersen	other	1	recruiting
NCT04561518	ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)	No drug interventions	Not Available	Not Available	recruiting
NCT05661916	A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALN-TTRSC04 in Healthy Subjects	No drug interventions	treatment	1	recruiting
NCT02797847	A Safety and Tolerability Study of an Investigational Drug, ALN-TTRSC02, in Healthy Subjects	Vutrisiran	treatment	1	completed
NCT01148953	Trial to Evaluate Safety and Tolerability of ALN-TTR01 in Transthyretin (TTR) Amyloidosis	No drug interventions	treatment	1	completed
NCT03336580	A Study of PRX004 in Subjects With Amyloid Transthyretin (ATTR) Amyloidosis	Coramitug	treatment	1	terminated
NCT02595983	The Study of an Investigational Drug, Revusiran (ALN-TTRSC), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis in Patients Whose Disease Has Continued to Worsen Following Liver Transplant	Revusiran	treatment	2	completed
NCT02053454	A Study of the Safety, Tolerability and Pharmacokinetics of ALN-TTR02 in Japanese Healthy Volunteers	Patisiran	treatment	1	completed
NCT01623245	Prevalence of Transthyretin Amyloidosis in Hypertrophic Cardiomyopathy	No drug interventions	Not Available	Not Available	completed
NCT06355934	OverTTuRe: Characteristics, Treatment Patterns and Outcomes of Patients With ATTR Amyloidosis	No drug interventions	Not Available	Not Available	recruiting
NCT05184088	Efficacy of [18F]Florbetaben PET for Diagnosis of Cardiac AL Amyloidosis	Florbetaben F-18	diagnostic	3	recruiting
NCT06367842	Orthopaedic Specimen Pathology and Early Diagnosis of ATTR Cardiopathy (ATTR-ORTHO)	No drug interventions	Not Available	Not Available	recruiting
NCT05444920	The Italian Transthyretin Amyloidosis Web-Network	No drug interventions	Not Available	Not Available	recruiting