Epilepsy, Primary Generalized Tonic-Clonic Seizures (DBCOND0054806)

Identifiers

Synonyms

Epilepsy, Tonic-Clonic / Grand mal / Tonic-clonic epilepsy / Primary generalized tonic-clonic seizure Epilepsy / Major convulsion / Tonic/ clonic convulsions / Tonic-clonic convulsion / Epilepsy grand mal / Grand mal epilepsy / Clonic-tonic convulsions / Grand mal convulsion / Convulsion grand mal / Convulsions grand mal / Tonic-clonic epileptic seizure (finding) / Other generalized epilepsy and epileptic syndromes / Tonic-Clonic Seizures / Grand mal seizure / Generalised tonic-clonic seizure / Seizure grand mal / Grand mal fit / Grand mal epileptic fit / Generalized tonic-clonic seizure / Generalised tonic-clonic seizures

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Perampanel	A non-competitive AMPA glutamate receptor antagonist used to treat partial-onset seizures with or without secondarily generalized seizures, and as adjunctive treatment of primary generalized tonic-clonic seizures in patients with epilepsy.	Glutamate receptor 1target Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2B6enzyme Glutamate receptor 2target Glutamate receptor 3target Glutamate receptor 4target
Topiramate	An anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines.	Gamma-aminobutyric acid receptor subunit alpha-1target Voltage-gated sodium channel alpha subunittarget Carbonic anhydrase 2target Carbonic anhydrase 4target Kainate receptorstarget Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme Carbonic anhydrase 1target Carbonic anhydrase 3target Voltage gated L-type calcium channeltarget Voltage-dependent R-type calcium channeltarget Albumincarrier ATP-dependent translocase ABCB1transporter 5'-AMP-activated protein kinasetransporter Glutamate receptor ionotropic, kainate 1target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01463306	A 12-Month Study To Evaluate The Safety And Tolerability Of Pregabalin As Add-On Therapy In Pediatric Subjects 1 Month To 16 Years Of Age With Partial Onset Seizures And Pediatric And Adult Subjects 5 To 65 Years Of Age With Primary Generalized Tonic-Clonic Seizures	Pregabalin	treatment	3	completed
NCT03446664	Microburst Vagus Nerve Stimulator (VNS) Therapy Feasibility Study	No drug interventions	treatment	Not Available	completed
NCT03831802	Embrace and Quality of Life	No drug interventions	supportive_care	Not Available	terminated
NCT00150787	Monotherapy With Levetiracetam or Carbamazepine in Patients Suffering From Epilepsy.	Levetiracetam	Not Available	3	completed
NCT04770337	Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy	No drug interventions	treatment	Not Available	recruiting
NCT00150813	Monotherapy With Levetiracetam in Patients Suffering From Epilepsy.	Levetiracetam	treatment	3	completed
NCT04282681	XLTCS - Accelerometer Data Collection in an Epilepsy Monitoring Unit (EMU)	No drug interventions	Not Available	Not Available	withdrawn
NCT01439438	Topiramate Bioequivalence Study Brazil - Fast	Topiramate	other	1	completed
NCT00231556	A Study on Safety and Efficacy of Two Doses of Topiramate as Monotherapy in the Treatment of Newly Diagnosed or Recurrent Epilepsy	Topiramate	treatment	3	completed
NCT00104416	Study Evaluating LAMICTAL Extended-Release Therapy Added To Current Seizure Treatments In Patients With Primary Generalized Tonic-Clonic Seizures (PGTC) Seizures	Lamotrigine	treatment	3	completed
NCT00043901	Treatment Of Primary Generalized Tonic-Clonic Seizures With An Investigational New Drug	Lamotrigine	treatment	4	completed