Locally Advanced or Metastatic Non-small Cell Lung Cancer (DBCOND0055934)

Identifiers

Synonyms

Locally Advanced or Metastatic Non Small Cell Lung Cancer / Locally Advanced/ Metastatic NSCLC / Metastatic or Locally Advanced NSCLC / Locally Advanced or Metastatic NSCLC / Locally Advanced Metastatic NSCLC

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Repotrectinib	A tyrosine kinase inhibitor used to treat locally active or metastatic non-small cell lung cancer	Proto-oncogene tyrosine-protein kinase ROStarget High affinity nerve growth factor receptortarget BDNF/NT-3 growth factors receptortarget NT-3 growth factor receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Multidrug and toxin extrusion protein 2transporter Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A5enzyme UDP-glucuronosyltransferase 1A1enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05000710	Concomitant Radiotherapy, Tremelimumab & Durvalumab for Advanced NSCLC Patients Progressing on First-line Immunotherapy	Durvalumab Tremelimumab	treatment	2	recruiting
NCT01526928	Study to Evaluate Safety, Pharmacokinetics, and Efficacy of Rociletinib (CO-1686) in Previously Treated Mutant Epidermal Growth Factor Receptor (EGFR) in Non-Small Cell Lung Cancer (NSCLC) Patients	Rociletinib	treatment	1 / 2	terminated
NCT05048797	A Study to Investigate the Efficacy and Safety of Trastuzumab Deruxtecan as the First Treatment Option for Unresectable, Locally Advanced/Metastatic Non-Small Cell Lung Cancer With HER2 Mutations	Carboplatin Cisplatin Pembrolizumab Pemetrexed Trastuzumab deruxtecan	treatment	3	recruiting
NCT04686305	Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC	Carboplatin Cisplatin Durvalumab Pemetrexed Rilvegostomig Trastuzumab deruxtecan Volrustomig	treatment	1	recruiting
NCT05673590	Utidelone Versus Docetaxel in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer	Docetaxel Utidelone	treatment	3	recruiting
NCT05513664	Real-World Effectiveness of Osimertinib for Patients With Non-Small Cell Lung Cancer	Osimertinib	Not Available	Not Available	unknown_status
NCT04996121	A Study of XZP-5955 Tablets in Patients With NTRK or ROS1 Fusion Positive Locally Advanced or Metastatic Solid Tumors	No drug interventions	treatment	1 / 2	recruiting
NCT04448379	Efficacy and Safety of JMT101 Combined With Afatinib (or Osimertinib) in Patients With Non-Small Cell Lung Cancer	Afatinib Becotatug Osimertinib	treatment	1	unknown_status
NCT05132777	Efficacy and Safety of JMT101 Combined With Osimertinib in Patients With Non-Small Cell Lung Cancer	Becotatug Osimertinib	treatment	2	not_yet_recruiting
NCT05863325	A Study to Compare the Efficacy and Safety of HB1801 to Taxotere in Advanced Non-Small Cell Lung Cancer (NSCLC)	Docetaxel	treatment	2	recruiting
NCT04606446	Study of PF-07248144 in Advanced or Metastatic Solid Tumors	Fulvestrant Letrozole Palbociclib	treatment	1	recruiting
NCT03274479	PBF-1129 in Patients With NSCLC	No drug interventions	treatment	1	active_not_recruiting
NCT04143607	ASK120067 Versus Gefitinib as First-line Treatment for EGFRm Locally Advanced or Metastatic NSCLC	Gefitinib	treatment	3	active_not_recruiting
NCT04207775	Real World Study in Locally Advanced or Metastatic NSCLC Patients, Progressed From First-line EGFR-TKI Therapy	No drug interventions	Not Available	Not Available	completed
NCT03037086	Asia PDL1 Study Among NSCLC Patients	No drug interventions	Not Available	Not Available	completed
NCT03502850	Safety, Tolerability, Pharmacokinetics and Anti-tumour Activity of ASK120067 in Locally Advanced and Metastatic Non Small Cell Lung Cancer	No drug interventions	treatment	1 / 2	unknown_status
NCT05631678	Drug-drug Interaction Study Beteewn ASK120067 and Rifampicin or Itraconazole	Itraconazole Rifampin	treatment	1	completed
NCT06461156	A Study of HS-10504 in Patients With Advanced or Metastatic Non-Small-Cell Lung Cancer(NSCLC)	No drug interventions	treatment	1	not_yet_recruiting
NCT04360915	Assessing the Pharmacokinetics Effects of Food on ASK120067 in Single Oral Administration in Chinese Healthy Subjects	No drug interventions	treatment	1	completed
NCT05662670	A Phase I/II Study of WJ13404 Monotherapy in Patients With Advanced or Mentastatic Non-Small Cell Lung Cancer	No drug interventions	treatment	1 / 2	recruiting
NCT04667234	Expanded Access of Sotorasib	Sotorasib	Not Available	Not Available	no_longer_available
NCT05990127	A Study of AK104/Tislelizumab With Chemotherapy as First-line Treatment in PD-L1 TPS < 1% Non-small Cell Lung Cancer	Cadonilimab Carboplatin Paclitaxel Pemetrexed Tislelizumab	treatment	3	not_yet_recruiting
NCT03414814	Osimertinib for NSCLC With EGFR Exon 20 Insertion Mutation	Osimertinib	treatment	2	completed
NCT03969823	Whole Genomic Landscape of Advanced EGFR-mutant NSCLC	Osimertinib	other	Not Available	active_not_recruiting
NCT04208854	Observational Study With Metronomic Oral Vinorelbine in Elderly Patients With Locally Advanced / Metastatic Non-small-cell Lung Cancer (NSCLC)	Vinorelbine	Not Available	Not Available	unknown_status