Proliferative Diabetic Retinopathy (PDR) (DBCOND0056889)

Identifiers

Synonyms
PDR - Proliferative Diabetic Retinopathy / Diabetic Proliferative Retinopathy / Proliferative Diabetic Retinopathy / Proliferative retinopathy due to diabetes mellitus (disorder) / Retinopathy due to diabetes mellitus (disorder) / Diabetic retinopathy / Retinopathy diabetic

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Ranibizumab
A recombinant humanized monoclonal antibody and VEGF-A antagonist used for the management of macular edema after retinal vein occlusion, age-related macular degeneration (wet), and diabetic macular edema.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04692688
Study of the Safety and Efficacy of APX3330 in Diabetic Retinopathytreatment2completed
NCT06412224
The Preliminary Safety and Efficacy of RRG001 After Vitrectomy in Subjects With Proliferative Diabetic Retinopathy (PDR)No drug interventionstreatment0recruiting
NCT00417833
Multifocal Electrophysiologic Findings After Intravitreal Bevacizumab(Avastin)TreatmentNot Available2 / 3terminated
NCT01869933
Phase I Study Assessing the Ocular and Systemic Safety and Tolerability of OC-10XNo drug interventionstreatment1completed
NCT02735369
A Study Assessing Efficacy and Safety of OC-10X in the Treatment of PDRNo drug interventionstreatment2terminated
NCT01760746
Comparison of Changes of Inflammatory Proteins in Aqueous Humour of Subjects Treated With Avastin vs LucentisNo drug interventionsNot AvailableNot Availablecompleted
NCT01594281
Multicenter 12 Months Clinical Study to Evaluate Efficacy and Safety of Ranibizumab Alone or in Combination With Laser Photocoagulation vs. Laser Photocoagulation Alone in Proliferative Diabetic Retinopathy (PRIDE)treatment2completed
NCT00516464
Evaluation of Ranibizumab in Proliferative Diabetic Retinopathy (PDR) Requiring Vitrectomytreatment3unknown_status
NCT05169502
Discovering Early Biomarkers in Circulating Endothelial Cells for Diabetes Complications by Single Cell RNA SequencingNo drug interventionsNot AvailableNot Availablecompleted
NCT05393284
Phase 2 Spectra Study to Evaluate the Safety and Efficacy of OPL-0401 in Patients With Diabetic RetinopathyNo drug interventionstreatment2active_not_recruiting
NCT01920984
Vitreous Levels of Cysteine-rich 61 in Patients With Proliferative Diabetic Retinopathybasic_scienceNot Availablecompleted
NCT01724554
Impact of Intravitreal Aflibercept Injections on Capillary Non-Perfusiontreatment1 / 2completed
NCT05631054
Establishment and Validation of a Risk Prediction Model for Long-term Low Vision After Vitrectomy in PDR PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT02863354
Intravitreal Aflibercept for Retinal Non-Perfusion in Proliferative Diabetic Retinopathytreatment2completed
NCT04674254
Macular Perfusion Changes After Anti-VEGF Versus Targeted Retinal Photocoagulation in Proliferative Diabetic Retinopathytreatment4completed
NCT04285151
Nd:YAG Laser Hyaloidotomy for Premacular Hemorrhage in Diabetic EyesNo drug interventionstreatmentNot Availablecompleted
NCT01627977
Association of Lutein, Zeaxanthin and Brilliant Blue in ChromovitrectomyNo drug interventionssupportive_care3completed
NCT04380077
Gas Tamponade for Prevention of Postoperative Vitreous Hemorrhage in DiabeticsNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT06583798
Outcomes of Retinal Re-suregries in Silicone Oil Filled EyesNo drug interventionsNot AvailableNot Availablecompleted
NCT01389505
Bevacizumab as Adjunctive Treatment to Laser Panretinal Photocoagulation for Proliferative Diabetic RetinopathyNo drug interventionstreatment2unknown_status
NCT00563628
Changes in Macular Thickness After Patterns Scan LaserNo drug interventionstreatment4terminated
NCT02911311
Conbercept vs Panretinal Photocoagulation for the Management of Proliferative Diabetic RetinopathytreatmentNot Availableunknown_status
NCT01854593
Prospective Randomized Controlled Study of Intravitreal Injection of Bevacizumab for Proliferative Diabetic Retinopathytreatment4completed
NCT01486771
Macugen for Proliferative Diabetic Retinopathy Study With Extended Dosing (M-PDRS ED)treatment4unknown_status
NCT00668785
Intravitreal Ranibizumab to Treat Macular Edema After Panretinal Photocoagulation (Phase II)treatment2terminated
NCT02447185
25-G Vitrectomy With Ranibizumab or Triamcinolone Acetonide on PDR in China-Randomized Clinical Trialprevention3unknown_status
NCT05677685
VISUPRIME® Eye DropsNo drug interventionspreventionNot Availablecompleted
NCT01724385
Intravitreal Bevacizumab for Proliferative Diabetic Retinopathytreatment4completed
NCT00996437
Intravitreal Ranibizumab for Vitreous Hemorrhage Due to Proliferative Diabetic Retinopathy (N)treatment2 / 3completed
NCT01044875
Trial of Yellow 577 nm Laser Versus Green 532 nm Laser for Proliferative Diabetic RetinopathyNo drug interventionstreatmentNot Availableunknown_status
NCT01568242
Changes in Vitreous Temperature During PhacoemulsificationNo drug interventionsbasic_scienceNot Availablewithdrawn
NCT03113006
The Individually-Marked Panretinal Laser phoTocoagulation for Proliferative Diabetic Retinopathy Study (TREAT)No drug interventionstreatmentNot Availablecompleted
NCT05414149
Efficacy and Safety Comparison of IVR and IVC Before Vitrectomy in Proliferative Diabetic RetinopathyNo drug interventionstreatmentNot Availablecompleted
NCT00600236
HLA and it Relation With the Development of Proliferative Diabetic Retinopathy in Mexican PopulationNo drug interventionsprevention3withdrawn
NCT02067013
Analysis of Aqueous and Vitreous Humorbasic_science2unknown_status
NCT03490318
Effectiveness of Multimodal Imaging for the Evaluation of Retinal Oedema And New vesseLs in Diabetic RetinopathyNo drug interventionsNot AvailableNot Availablecompleted
NCT05408416
Comparison of Surgery Outcome Between Preoperative IVR and Intraoperative IVR in PPV for PDRNo drug interventionstreatmentNot Availablecompleted
NCT00776763
Ocular Growth Factors Profile in Proliferative Retinopathies Before and After Intravitreal Bevacizumabtreatment2completed
NCT01478763
Vitrous Analysis in Proliferative Diabetic RetinopathyNo drug interventionsNot AvailableNot Availablecompleted
NCT00993525
Intravitreal Ranibizumab For Persistent New Vessels In Diabetic Retinopathy(Inipe Study)treatment1 / 2unknown_status
NCT01737957
Safety and Efficacy of Low-Fluence PRP for PDRNo drug interventionstreatmentNot Availableterminated
NCT01758757
Comparison of Small-gauge Vitrectomy and Conventional Vitrectomy for Proliferative Diabetic RetinopathyNo drug interventionstreatmentNot Availablecompleted
NCT02096874
Bevacizumab and Peripheral Retinal Changes on Wide Field Angiography in Diabetic Macular Edematreatment4completed
NCT01813773
Treatment With Intravitreal Aflibercept Injection For Proliferative Diabetic Retinopathy, The A.C.T Studytreatment2 / 3completed
NCT00529594
Analgesic Effect of Etoricoxib (ARCOXIA®) 120MG During Retinal Laser PhotocoagulationtreatmentNot Availablecompleted
NCT01383772
Retinal Laser by Multi-spot Photocoagulator and Driving EligibilityNo drug interventionshealth_services_researchNot Availablecompleted
NCT00802269
Pain Using Reduced Fluence Parameters in Photocoagulation for Diabetic Retinopathy.No drug interventionstreatment4terminated
NCT02157350
The Individually Marked Panretinal lasEr phoTokoagUlation for Proliferative Diabetic Retinopathy Study - DETECTNo drug interventionstreatment3completed
NCT06549023
Single Session vs Multiple-Session Panretinal Photocoagulation for Treatment of Proliferative Diabetic RetinopathyNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT00563043
Changes in Electroretinogram and Contrast Sensitivity After PASCAL TreatmentNo drug interventionstreatment4terminated
NCT00445003
Laser-Ranibizumab-Triamcinolone for Proliferative Diabetic Retinopathytreatment3completed
NCT01041690
Efficacy of PreOperative Bevacizumab for Diabetic Eye DiseasetreatmentNot Availablecompleted
NCT05156021
A Study on the Treatment Strategy of NVG Secondary to PDRNo drug interventionstreatmentNot Availablecompleted
NCT04800679
Intravitreal Bevacizumab vs Laser vs Combination of Bevacizumab and Modified Laser in PDRtreatment2unknown_status
NCT01232179
Comparison of Two Laser Therapy Methods for PDRNo drug interventionstreatment2unknown_status
NCT05222633
Anti-VEGF in Real-worldNot AvailableNot Availableunknown_status
NCT01946451
Gene Expression in Patients With Epiretinal MembranesNo drug interventionsNot AvailableNot Availableunknown_status
NCT02630277
Evaluation of Treatment of High riSk proLiferative Diabetic retinopathY With Intravitreal Aflibercept injectioNtreatment2unknown_status
NCT01790945
Diabetic Macular Edema and Diabetic Retinopathy Screening (TeleMed) With Automated Retinal PhotographyNo drug interventionsNot AvailableNot Availableunknown_status
NCT00745498
Pre- and Intra-operative Intravitreal Bevacizumab Injection in Diabetic VitrectomytreatmentNot Availablecompleted
NCT00728598
Fractalkine, a CX3C Chemokine, Act as a Mediator of Ocular AngiogenesisNo drug interventionsNot AvailableNot Availablecompleted
NCT00596505
Intravitreal Bevacizumab Pretreatment for Reducing Preretinal Hemorrhage in Diabetic VitrectomyNo drug interventionsNot AvailableNot Availablecompleted
NCT03522311
Surgical Outcomes for Proliferative Diabetic Retinopathy by Preoperative Glycemic Control and Renal FunctionNo drug interventionsNot AvailableNot Availablecompleted
NCT05642793
Effect of Postvitrectomy Proactive Use of Conbercept on Postoperative Complications in PDR Patientsprevention2recruiting
NCT01312207
Macular Tractional Retinoschisis in Proliferative Diabetic RetinopathyNo drug interventionsNot AvailableNot Availableunknown_status
NCT01478737
Intravitreal Ozurdex After Pars Plana Vitrectomy for Proliferative Diabetic Retinopathyprevention2completed
NCT01571232
Ozurdex for Treatment of Recalcitrant Diabetic Macular Edematreatment2completed
NCT02005432
PASCAL Laser Versus ETDRS Laser Associated With Intravitreal Ranibizumab (IVR) Versus Only IVR for Proliferative Diabetic RetinopathyNo drug interventionstreatment4unknown_status
NCT02753400
Study to Evaluate Effects of Emixustat Hydrochloride in Subjects With Proliferative Diabetic Retinopathytreatment2completed
NCT02464800
Efficacy of Higher Cutting Rate in Microincision Vitrectomy for Proliferative Diabetic RetinopathyNo drug interventionsNot AvailableNot Availablecompleted
NCT00545870
Bevacizumab Versus Ranibizumab for Diabetic Retinopathytreatment3completed
NCT00170742
Study to Assess the Efficacy and Safety of Monthly Octreotide Intramuscular Injections in Patients With Proliferative Diabetic Retinopathy After Lasercoagulation This Study is Not Being Conducted in the United States.treatment3terminated
NCT03525899
Macular Hole After Diabetic VitrectomyNo drug interventionsNot AvailableNot Availablecompleted
NCT02328118
25-Gauge Vitrectomy With Ranibizumab or Triamcinolone Acetonide on Proliferative Diabetic Retinopathy in Chinatreatment2 / 3unknown_status
NCT01589718
A Study of the Safety, Tolerability, and Efficacy of IVT Pre-op 0.3mg Pegaptanib Sodium Versus Sham, for Management of Tractional Retinal Detachment and Vitreous Hemorrhage With Proliferative Diabetic Retinopathytreatment3withdrawn
NCT01069341
Use of Ranibizumab to Treat Rubeosis in Diabetics Prior to Cataract Surgerytreatment1completed
NCT04278417
Study of Efficacy and Safety of Brolucizumab Versus Panretinal Photocoagulation Laser in Patients With Proliferative Diabetic Retinopathytreatment3active_not_recruiting
NCT01025934
Intravitreal Bevacizumab for Surgical Treatment of Severe Proliferative Diabetic Retinopathytreatment4completed
NCT03609996
Retrospective Review of Proliferative Diabetic Retinopathy PatientsNot AvailableNot Availableunknown_status
NCT00656435
Bevacizumab and Long Acting Gas in Diabetic Vitrectomytreatment3completed
NCT00737022
Macular Appearance After Diabetic VitrectomyNo drug interventionsNot AvailableNot Availablecompleted
NCT02879422
Genetic Markers and Proliferative Diabetic RetinopathyNo drug interventionsbasic_scienceNot Availablecompleted
NCT05514925
Cryoapplication Versus Anti-VEGF Before Diabetic Vitrectomytreatment4unknown_status
NCT05446948
Observation of the Efficacy of Different Vitrectomy Systems to Treat Proliferative Diabetic RetinopathyNo drug interventionstreatmentNot Availablecompleted
NCT00403026
Intravitreal Bevacizumab for Retinal DisorderstreatmentNot Availableunknown_status
NCT03633266
Anti-VEGF Instead of Intraoperative PRP in Proliferative Diabetic RetinopathyNo drug interventionstreatmentNot Availableunknown_status
NCT00737074
Macular Hole in Diabetic RetinopathyNo drug interventionsNot AvailableNot Availablecompleted
NCT02705274
PRP vs Bevacizumab for PDR Treatmenttreatment2 / 3completed
NCT02858076
Anti-VEGF vs. Prompt Vitrectomy for VH From PDRtreatment2 / 3completed
NCT04464694
Pre-vitrectomy Intravitreal Ranibizumab for Patients With Proliferative Diabetic Retinopathy Combined With Diabetic Macular Edematreatment4unknown_status
NCT05938491
OCT and OCT-A Afer Diabetic Vitrectomy in PDRNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT02857491
Intravitreal Injection of Ranibizumab Versus Sham Before Vitrectomy in Patients With Proliferative Diabetic RetinopathytreatmentNot Availablecompleted
NCT00600262
Intravitreal Bevacizumab for Diabetic Retinopathytreatment2 / 3terminated
NCT01589029
A Pilot Study on the Effects of ILARIS® on Patients With Proliferative Diabetic Retinopathy (PDRP)treatment1terminated
NCT01489189
Prompt Panretinal Photocoagulation Versus Ranibizumab+Deferred Panretinal Photocoagulation for Proliferative Diabetic Retinopathytreatment3completed
NCT01921192
Effect of Folic Acid, Vitamin B6 and Vitamin B12 in Diabetic Retinopathytreatment4unknown_status
NCT00682240
Morphological and Functional Retinal Changes Following Retinal PhotocoagulationNo drug interventionsNot Available4completed
NCT05478967
The Effect of IVA for Preventing Postvitrectomy Hemorrhage in PDRNo drug interventionsotherNot Availablecompleted
NCT01307072
Compliance to Ophthalmic Follow-up Examinations and Surgical Outcome for Proliferative Diabetic RetinopathyNo drug interventionsNot AvailableNot Availablecompleted
NCT02976012
Endolaserless Vitrectomy With Intravitreal IAI for PDR-Related VHtreatment1 / 2unknown_status
NCT02816710
Conbercept Injection in Treatment of Severe Proliferative Diabetic Retinopathytreatment4completed
NCT00446381
Effect of Macugen(Pegaptanib)on Surgical Outcomes and VEGF Levels in Diabetic Patients With PDR (Diabetic Retinopathy or CSDME (Macular Edema)diagnosticNot Availablecompleted
NCT01535495
Propranolol for Diabetic Retinopathytreatment1completed
NCT00907114
Topic Ketorolac Added to Panphotocoagulation in Proliferative Diabetic Retinopathytreatment2completed
NCT03506750
Day Regimes of CONbercept on CytokinEs of PDR Patients Undergoing Vitrectomy - Trial (CONCEPT)No drug interventionstreatment4unknown_status
NCT01928550
Diabetes PRP and OCTNo drug interventionsNot AvailableNot Availablecompleted
NCT00606138
Ranibizumab for Treatment of Persistent Diabetic Neovascularization Assessed by Wide-Field Imagingtreatment1 / 2completed