Grand Mal Status Epilepticus (DBCOND0057841)

Identifiers

Synonyms

Status epilepticus grand mal / Grand mal status, epileptic / Grand mal status (disorder) / Convulsive status epilepticus / Prolonged seizure / Status epilepticus

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Phenytoin	An anticonvulsant drug used in the prophylaxis and control of various types of seizures.	Sodium channel protein type 5 subunit alphatarget Sodium channel protein type 1 subunit alphatarget Cytochrome P450 2C8enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2B6enzyme Cytochrome P450 3A5enzyme Albumincarrier Cytochrome P450 3A4enzyme Solute carrier organic anion transporter family member 1C1transporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 3A7enzyme Nuclear receptor subfamily 1 group I member 2target Sodium channel regulatory subunit beta-1target Sodium channel protein type 3 subunit alphatarget UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1-6enzyme UDP-glucuronosyltransferase 1A9enzyme Thyroxine-binding globulincarrier Voltage-gated inwardly rectifying potassium channel KCNH2target Voltage-dependent L-type calcium channeltarget Sodium channel protein type 2 subunit alphatarget Sodium channel protein type 8 subunit alphatarget GABA(A) Receptortarget Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2E1enzyme Epoxide hydrolase 1enzyme UDP-glucuronosyltransferase 1A4enzyme Catechol O-methyltransferaseenzyme NAD(P)H dehydrogenase [quinone] 1enzyme Cytochrome P450 2C18enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02920060	Levetiracetam Versus Sodium Valproate in Children With Refractory Generalized Convulsive Status Epilepticus	Levetiracetam Valproic acid	treatment	2	completed
NCT01586208	Refractory Status Epilepticus Treatment Study	Phenytoin Valproic acid	treatment	3	completed