High Risk Prostate Cancer (DBCOND0059319)

Identifiers

Synonyms

High-risk Prostate Cancer

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Abiraterone	An antiandrogen used in the treatment of metastatic castration-resistant prostate cancer and metastatic high-risk castration-sensitive prostate cancer.	Steroid 17-alpha-hydroxylase/17,20 lyasetarget Albumincarrier Alpha-1-acid glycoprotein 1carrier Cytochrome P450 3A4enzyme Sulfotransferase 2A1enzyme Multidrug resistance-associated protein 1transporter Cytochrome P450 2D6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A5enzyme Solute carrier organic anion transporter family member 1B1transporter
Piflufolastat F 18	A radiopharmaceutical diagnostic agent used with PET to image PSMA-positive lesions for the diagnosis of metastatic or recurrent prostate cancer.	Glutamate carboxypeptidase 2target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02107287	Hypofractionated Intensity Modulated Radiation Therapy Plus Hormonal Therapy in Patients With High Risk Prostate Cancer	No drug interventions	treatment	Not Available	completed
NCT04236752	Stereotactic Pelvic Brachytherapy With HDR Boost for Dose Escalation in High Tier Intermediate and High Risk Prostate ca	No drug interventions	treatment	Not Available	unknown_status
NCT02268175	Enzalutamide/Leuprolide +/- Abiraterone/Pred in Prostate	Abiraterone Enzalutamide Leuprolide Lidocaine Prednisone	treatment	2	completed
NCT01695473	Neoadjuvant BKM120 in High-risk Prostate Cancer	Buparlisib	treatment	2	terminated
NCT03537391	Novel Imaging in Staging of Primary Prostate Cancer	No drug interventions	diagnostic	Not Available	completed
NCT03340272	PROspective Multicenter Observational Study on Elective Pelvic Nodes Irradiation.	No drug interventions	Not Available	Not Available	unknown_status
NCT05406999	Neoadjuvant Intense Endocrine Therapy for High Risk and Locally Advanced Prostate Cancer	Abiraterone Apalutamide Enzalutamide Prednisolone Rezvilutamide	treatment	2	recruiting
NCT03541928	Phase II High Risk Prostate Cancer Trial Using Gene & Androgen Deprivation Therapies, Radiotherapy, & Surgery	Aglatimagene besadenovec Bicalutamide Leuprolide Nalotimagene carmaleucel Thymidine Valaciclovir	treatment	2	unknown_status
NCT05223582	Fluzoparib and Abiraterone in the preSurgery Treatment of Prostate Cancer: FAST Trial	Abiraterone Fluzoparib Prednisone	treatment	2	active_not_recruiting
NCT05593497	A Single-Arm Phase II Study of Neoadjuvant Intensified Androgen Deprivation (Leuprolide and Abiraterone Acetate) in Combination With AKT Inhibition (Capivasertib) for High-Risk Localized Prostate Cancer With PTEN Loss	Abiraterone Capivasertib	treatment	2	recruiting
NCT03362359	Ga-68-PSMA-11 in High-risk Prostate Cancer	No drug interventions	diagnostic	1 / 2	completed
NCT05558735	Contribution of Canine Detection in the Diagnostic Strategy of High-risk Prostate Cancer (Prostate-K9-Detect)	No drug interventions	Not Available	Not Available	recruiting
NCT01488968	Conventional Versus Hypofractionated Radiation in High Risk Prostate Patients	No drug interventions	treatment	Not Available	unknown_status