NCT06571045
A Study to Evaluate the Efficacy and Safety of 2 Doses of EYE103 Compared With Ranibizumab (0.5 mg) in Participants With DME treatment 2 / 3 recruiting NCT04697758
Safety and Bioactivity of AXT107 in Subjects With Diabetic Macular Edema No drug interventions treatment 1 / 2 terminated NCT02633852
Multicenter Study to Evaluate the Efficacy of Treat and Extend Regimen of Aflibercept (EYLEA) as a Second Line Treatment for Diabetic Macular Edema treatment 4 completed NCT02050828
The TIME-2 Study: A Phase 2 Study of AKB-9778, a Novel Tie-2 Activator, in Patients With Diabetic Macular Edema treatment 2 completed NCT06398080
An Observational Study to Investigate the Use of Aflibercept 8 mg to Treat Adult Patients With Neovascular Age-Related Macular Degeneration (nAMD) and Diabetic Macular Edema (DME) in a Real-World Setting Not Available Not Available not_yet_recruiting NCT05989126
Study to Evaluate an 8 mg Aflibercept (EYLEA®) Prefilled Syringe (PFS) treatment 3 completed NCT04739306
Study to Compare Efficacy and Safety of CT-P42 in Comparison With Eylea in Patients With Diabetic Macular Edema treatment 3 completed NCT05919693
A 2-part Study Consisting of Multiple Ascending Dose (MAD) Safety Study, and a Dose-finding Masked Study to Assess the Safety and Efficacy of Intravitreal (IVT) EYE103 in Patients With Diabetic Macular Edema (DME) or Neovascular Age-related Macular Degeneration (NVAMD) No drug interventions treatment 1 / 2 completed NCT02080091
Observational Study to Assess the Effect of Iluvien® in DME Patients Insufficiently Responsive to Available Therapies No drug interventions Not Available Not Available terminated NCT03859245
Photobiomodulation & Ketogenic Diet for Treatment of Mid-periphery Retinal Disorders for Alzheimer's Disease Prevention No drug interventions treatment Not Available unknown_status NCT03635814
The Study to YD312 Tablet in Patients With Diabetic Macular Edema No drug interventions treatment 2 unknown_status NCT06116916
Study to Assess the Efficacy & Safety of KHK4951 in Patients With Diabetic Macular Edema treatment 2 recruiting NCT04543331
Observational Study to Evaluate Fluid Resolution and Effectiveness in Patients Receiving Beovu in Neovascular Age-related Macular Degeneration and Visual Impairment Due to Diabetic Macular Edema Not Available Not Available active_not_recruiting NCT04857996
Safety, Tolerability and Evidence of Activity Study of UBX1325 in Patients With Diabetic Macular Edema (BEHOLD) No drug interventions treatment 2 completed NCT02585401
Evaluation of Physician Knowledge of Safety and Safe Use Information for Aflibercept in Canada Not Available Not Available completed NCT02424019
Phase 4 IOP Signals Associated With ILUVIEN® treatment 4 completed NCT01702441
Safety and Pilot Efficacy of AKB-9778 in Subjects With Diabetic Macular Edema treatment 1 / 2 completed NCT00936520
SAR 1118 in Human Subjects Undergoing Pars Plana Vitrectomy treatment 1 terminated NCT02457884
Effectiveness of Training in Reading Rehabilitation for Patients With Diabetic Macular Oedema No drug interventions other Not Available completed NCT02554747
Aflibercept anD navigateD vErsus coNvensional Laser in Diabetic macUlar edeMa No drug interventions treatment Not Available completed NCT02731911
Study of OZURDEX® in the Treatment of Diabetic Macular Oedema (DME) in Australia - The AUSSIEDEX Study Not Available Not Available completed NCT02181400
Near Infrared Photobiomodulation Treatment for Diabetic Macular Oedema No drug interventions treatment Not Available completed NCT00167518
Intravitreal Triamcinolone for Clinically Significant Diabetic Macular Oedema That Persists After Laser Treatment (TDMO) treatment 2 / 3 completed NCT00427986
Clinical Study of the Effect of Intravenous Galactose on Diabetic Macular Oedema treatment Not Available terminated NCT00148330
Open Label Extension of a Clinical Trial of Intravitreal Triamcinolone for Diabetic Macular Oedema-TDMX Study treatment 2 / 3 completed NCT03495765
To Evaluate the Comparative Efficacy of Lucentis (Ranibizumab) 0.5mg Intravitreal Injection in Patients With Diabetic Macular Oedema (DME) With Well Controlled and Poorly Controlled Diabetes Mellitus treatment 3 completed NCT00148265
A Multicentre Randomised Clinical Trial of Laser Treatment Plus Intravitreal Triamcinolone for Diabetic Macular Oedema treatment 2 / 3 completed NCT04576689
Safety and Efficacy of IBE-814 Intravitreal (IVT) Implant - A Sustained, Low Dose Dexamethasone Therapy No drug interventions treatment 2 completed NCT00333671
Quantification of Rising the Osmotic Pressure in Diabetic Intraretinal Fluid Accumulation (Diabetic Macular Oedema) basic_science Not Available completed NCT01175070
Intravitreal Macugen for Ischaemic Diabetic Macular Oedema treatment 4 completed NCT02309476
Sub-threshold Photocoagulation of Diabetic Macular Oedema No drug interventions treatment Not Available withdrawn NCT01787669
Trial of Switching Between Intravitreal Bevacizumab (Avastin®)& Intravitreal Dexamethasone (Ozurdex™) for Persistent Diabetic Macular Oedema treatment 2 completed NCT02207712
Noctura400 Treatment for Diabetic Retinopathy (CANDLE) treatment Not Available terminated NCT02462304
To Compare Anti-VEGF Monotherapy With Anti-VEGF and EPM Grid Laser Combination Therapy for Diabetic Macular Edema treatment 4 unknown_status NCT02131350
Combination Treatment of Intravitreal Ranibizumab, Focal/Grid Laser and Panretinal Photocoagulation in Patients With Diabetic Macula Edema treatment 4 completed NCT04079231
Efficacy and Safety of Brolucizumab vs. Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema treatment 3 withdrawn NCT02788877
Treat-and-extend Regimen of Aflibercept in Diabetic Macular Edema (VIBIM Study) treatment 4 unknown_status NCT01994291
A Phase 2, Multi-Center Study To Compare The Efficacy And Safety Of A Chemokine CCR2/5 Receptor Antagonist With Ranibizumab In Adults With Diabetic Macular Edema treatment 2 terminated NCT06305143
Efficacy and Safety of Conbercept for Diabetic Macular Edema Combined With Severe Non-proliferative Diabetic Retinopathy treatment 4 recruiting NCT04910503
Medico Economic Evaluation of Fluocinolone Acetonide Implant Versus Dexametheasone Implant in Resistant Diabetic Macular Oedema other 4 recruiting NCT01975103
Non-damaging Retinal Laser Therapy With PASCAL Laser for Macular Diseases No drug interventions treatment 2 unknown_status NCT04429503
Study of a High-Dose Aflibercept in Participants With Diabetic Eye Disease treatment 2 / 3 completed NCT02002403
Efficacy and Safety Study to Evaluate Two Doses of Oral DMI-5207 in Adult Subjects With Diabetic Macular Edema treatment 2 completed NCT05080803
Diabetic Macular Edema: Relevance of Staging Progression on Therapeutic Outcome Not Available Not Available completed NCT03969303
NOTAL-OCT V.2.5 vs Commercial OCT in AMD Patients No drug interventions Not Available Not Available completed NCT04668703
Prophylactic Effect of Conbercept Intravitreal Injection at the Conclusion of Cataract Surgery for Diabetic Macular Edema No drug interventions prevention Not Available unknown_status NCT02232503
Prevalence of DIAbetic RETinopathy and Impact of Genetic Factors in the Development of Diabetic Retinopathy of Patients With Type 1 and 2 Diabetes Mellitus in SlovaKia No drug interventions Not Available Not Available completed NCT01635790
Comparing the Effectiveness and Costs of Bevacizumab to Ranibizumab in Patients With Diabetic Macular Edema (BRDME) treatment 2 / 3 unknown_status NCT03927690
Multiple Dose Safety and Efficacy of LKA651 in Patients With Diabetic Macular Edema treatment 2 completed NCT03397264
A Dose Ranging Study of OPT-302 With Aflibercept for Persistent Diabetic Macular Edema treatment 1 / 2 completed NCT04699864
Evaluation of NeoRetina Artificial Intelligence Algorithm for the Screening of Diabetic Retinopathy at the CHUM No drug interventions diagnostic Not Available not_yet_recruiting NCT02063321
Reading Center - Occurence of Diabetic Macular Edema in Patients With Diabetes Mellitus in Slovak Republic No drug interventions Not Available Not Available unknown_status NCT02363621
Evaluation of Inflammation and Pain Post Injection of Ranibizumab vs Aflibercept in Patients With DME treatment 2 completed NCT01546402
Intraoperative Dexamethasone Implant Improves Outcome of Cataract Surgery With Diabetic Macular Edema treatment 4 completed NCT04693702
Observational Study of Vision Improvement in Patients With Retinal Disorders No drug interventions Not Available Not Available completed NCT03835884
A Study Assessing AR-13503 Implant in Subjects With nAMD or DME No drug interventions treatment 1 completed NCT04537884
Safety and Tolerability Study of UBX1325 in Patients With Diabetic Macular Edema or Neovascular Age-Related Macular Degeneration No drug interventions treatment 1 completed NCT03784443
Combined Ranibizumab and Iluvien for Diabetic Macular Oedema treatment 2 / 3 withdrawn NCT02924987
Effect of Aflibercept (Eylea®) in the Management of Bevacizumab (Avastin®) Resistant Diabetic Macular Edema treatment 4 unknown_status NCT01319487
Safety and Efficacy Study of Topical Administration of FOV2304 (High Dose or Low Dose) for the Treatment of Center-involving Clinically Significant Macular Edema Associated With Diabetic Retinopathy No drug interventions treatment 2 completed NCT03732287
Cooling Anesthesia for Intravitreal Injection No drug interventions treatment 1 / 2 completed NCT05301751
AG-73305 Single Ascending Dose Cohort Study in DME No drug interventions treatment 2 active_not_recruiting NCT00412451
A Multicenter Study to Compare Multiple Doses of Intravitreal Microplasmin Versus Sham Injection for Treatment of Patients With Diabetic Macular Edema (DME) treatment 2 completed NCT02951351
Topical Proparacaine Eye Drops to Improve the Experience of Patients Undergoing Intravitreal Injections other Not Available completed NCT02221453
Cytokine Levels in Patients With Persistent Diabetic Macular Edema Treated With Triamcinolone Acetonide basic_science 2 completed NCT06572553
Evaluation of Therapeutic Efficacy of Faricimab for Clinical AMD, DME, and RVO Patients treatment 2 / 3 recruiting NCT02669953
Aflibercept in Recurrent or Persistent CNV Not Available Not Available recruiting NCT02227745
Efficacy of Dorzolamide as an Adjuvant After Focal Photocoagulation in Clinically Significant Macular Edema Not Available Not Available unknown_status NCT06011798
Assess the Efficacy and Safety of Repeat Intravitreal Injections of Foselutoclax (UBX1325) in Patients With DME (ASPIRE) treatment 2 recruiting NCT00496405
Unilateral Bevacizumab for Bilateral Diabetic Macular Edema other 4 withdrawn NCT04772105
Clinical Study of the Safety and Efficacy of BAT5906 Injection No drug interventions treatment 1 / 2 completed NCT05615805
The Effect of Ocular Rinse Volume on Surface Irritation After Intravitreal Injections No drug interventions supportive_care Not Available completed NCT03112005
Assessment of EyeArt as an Automated Diabetic Retinopathy Screening Tool No drug interventions Not Available Not Available completed NCT02933905
Influence of the Vitreomacular Interface on the Progression of the Diabetic Macular Edema After Anti-VEGF Injection Not Available Not Available completed NCT03598205
Curcumin and Intravitreal Dexamethasone in Diabetic Macular Edema No drug interventions supportive_care Not Available completed NCT01331005
NSAID Phase II for Non-central Involved Diabetic Macular Edema (DME) treatment 2 completed NCT02772497
3 Month Outcome of Ziv-aflibercept for DME treatment 2 / 3 completed NCT04856397
Ozurdex in Suboptimal Diabetic Macular Edema Patients treatment Not Available unknown_status NCT05066997
Pivotal Study of OCS-01 Eye Drops in Subjects With Diabetic Macular Edema (DIAMOND-1) treatment 2 / 3 recruiting NCT01728883
Diabetic Retinopathy And the Myvisiontrack® (DRAMA) Study No drug interventions Not Available Not Available completed NCT02796183
The Efficacy of Subconjunctival Bevacizumab in Diabetic Macular Edema treatment Not Available completed NCT02103283
A Phase 1, Open-Label Study of Teprotumumab in Patients With Diabetic Macular Edema (DME) treatment 1 completed NCT01189461
Study To Evaluate Safety And Tolerability Of Pegaptanib Sodium In Patients With Diabetic Macular Edema treatment 3 completed NCT05930561
4D-150 in Patients With Diabetic Macular Edema treatment 2 recruiting NCT03780361
Changes in Inflammatory Biomarkers Including Soluble CD14 and Hyperreflective Foci in DME Patients Treated With Aflibercept (FORESIGHT) basic_science 4 completed NCT00758628
Randomized, Double Blind Trial of Bromfenac BID (0.09%) as an Adjunct to Argon Laser Therapy in the Treatment of Diabetic Macular Edema. treatment 4 completed NCT02876393
A Systematic Study of Retinal Structure and Function in Diabetic Macular Oedema No drug interventions Not Available Not Available completed NCT01482871
Safety Study of ALG- 1001 to Treat Diabetic Macular Edema treatment 1 / 2 withdrawn NCT00737971
Efficacy Study of Triamcinolone and Bevacizumab Intravitreal for Treatment of Diabetic Macular Edema treatment 4 completed NCT04516278
A 3-month Study to Assess the Safety of ONS-5010 in Subjects With Visual Impairment Due to Retinal Disorders treatment 3 completed NCT02259088
A 12-month, Randomized, Efficacy and Safety Study of 0.5 mg Ranibizumab vs Laser in Chinese Diabetic Macular Edema (DME) Patients treatment 3 completed NCT01698788
Effect of Intraoperative Dexamethasone Implant in Taut Posterior Hyaloid Removal in Diabetic Macular Edema treatment Not Available completed NCT05610488
Intravitreal Faricimab in Diabetic Macular Edema With Limited Response to Aflibercept treatment 4 not_yet_recruiting NCT03975088
Sub-macular Injection of Ranibizumab as a New Surgical Treatment for Refractory Diabetic Macular Edema No drug interventions treatment Not Available completed NCT05019807
Comparing the Compliance to Follow-up in Patients With Diabetic Macular Edema No drug interventions health_services_research Not Available completed NCT04527107
A Study to Evaluate THR-149 Treatment for Diabetic Macular Oedema treatment 2 completed NCT05961007
Evaluation of IBI302 Injection in nAMD or DME treatment 1 / 2 suspended NCT05105607
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of D-4517.2 After Subcutaneous Administration in Healthy Participants No drug interventions treatment 1 completed NCT05697809
Suprachoroidal Sustained-Release OXU-001 Compared to Intravitreal Ozurdex® in the Treatment of Diabetic Macular Edema treatment 2 active_not_recruiting NCT00442156
The Course of Response to Focal Photocoagulation for DME No drug interventions Not Available Not Available completed NCT04067856
Intravitreal Dexamethasone Implant (Ozurdex) Versus Bevacizumab in Patients With Diabetic Macular Edema Undergoing Cataract Surgery treatment Not Available withdrawn NCT02555956
Grid Laser for Diffuse Diabetic Maculopathy No drug interventions Not Available Not Available completed NCT05343156
Efficacy and Safety of Dexamethasone Nanoparticles Eye Drops in Diabetic Macular Edema treatment 2 completed NCT04108156
This Study Will Evaluate the Efficacy, Safety, and Pharmacokinetics of the Port Delivery System With Ranibizumab in Participants With Diabetic Macular Edema Compared With Intravitreal Ranibizumab treatment 3 active_not_recruiting NCT01934556
A Safety and Efficacy Trial of a Treat and Extend Protocol Using Ranibizumab With and Without Laser Photocoagulation for Diabetic Macular Edema treatment 1 / 2 completed NCT04565756
A Study to Evaluate the Safety and Tolerability of EXN407 No drug interventions treatment 1 / 2 completed NCT05130385
High Resolution Optical Coherence Tomography No drug interventions Not Available Not Available recruiting NCT00464685
Safety and Efficacy of a New Treatment in Combination With Laser for Diabetic Macular Edema treatment 2 completed NCT05677685
VISUPRIME® Eye Drops No drug interventions prevention Not Available completed NCT00401115
Safety and Tolerability of MS-R001 in Patients With Diabetic Macular Edema Secondary to Diabetic Retinopathy treatment 1 completed NCT03328715
iOCT for Patients With Diabetic Macular Edema No drug interventions diagnostic Not Available completed NCT00490815
Pharmacokinetic and Efficacy Study of Fluocinolone Acetonide Inserts in Patients With Diabetic Macular Edema treatment 3 completed NCT00915837
Safety and Tolerability Study of the Helical Intravitreal Triamcinolone Implant in Diabetic Macular Edema treatment 1 completed NCT05387837
Safety, Tolerability and PK of Subcutaneous D-4517.2 in Subjects With Wet AMD or DME treatment 2 active_not_recruiting NCT00168337
A Study of the Safety and Efficacy of a New Treatment for Diabetic Macular Edema treatment 3 completed NCT04603937
A Study to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Participants With Diabetic Macular Edema (DME) treatment 3 terminated NCT01107132
Blood-retinal Barrier Imaging and Neuropsychiatric Sequela in Type 2 Diabetes Mellitus No drug interventions Not Available Not Available unknown_status NCT06173232
Assessment of Retinal Fundus Imaging Camera No drug interventions Not Available Not Available recruiting NCT03790852
Exploratory Study to Investigate the Bioactivity, Ocular and Systemic Safety, Tolerability, and Pharmacokinetics Following Single and Multiple Intravitreal Administrations of KSI-301 in Subjects With wAMD, DME and RVO treatment 1 terminated NCT04611152
A Trial to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Participants With Diabetic Macular Edema (DME) treatment 3 terminated NCT00444600
Laser-Ranibizumab-Triamcinolone for Diabetic Macular Edema treatment 3 completed NCT04635800
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of IVT MHU650 in Macular Edema Patients No drug interventions treatment 1 completed NCT00676559
Combined aPproach to Treatment Using Ranibizumab and Efalizumab for Diabetic Macular Edema Study: The CAPTURE DME Study treatment 1 withdrawn NCT04395859
Collateral Damage From the COVID-19 Pandemic Observed in Patients Treated With Intravitreal Injections (IVT) of Anti-angiogenic Agents No drug interventions Not Available Not Available completed NCT00576459
Safety and Efficacy of Intravitreal Fluocinolone Acetonide Implants in Patients With Diabetic Macular Edema treatment 2 completed NCT01342159
Intravitreal Bevacizumab and Triamcinolone in Diabetic Macular Edema No drug interventions treatment Not Available completed NCT02874859
Intravitreal Aflibercept InjectiOn in Vitrectomized Eyes for Treatment of Diabetic Macular Edema No drug interventions Not Available Not Available completed NCT05699759
Safety and Effect of Intravitreal Injection of a Derivative of Nucleoside Reverse Transcriptase Inhibitor in Subjects With Diabetic Macular Edema No drug interventions treatment 1 recruiting NCT02229175
Laser vs Bevacizumab Injection Alone in Treatment of Diabetic Macular Edema treatment 2 / 3 withdrawn NCT05494775
Effect of Corona Virus on Intravitreal Injections No drug interventions treatment Not Available unknown_status NCT02790775
Pain and Visual Outcome in Intravitreal Bevacizumab Injection No drug interventions prevention 2 completed NCT00779142
Utility of Intravitreal Methotrexate in Diabetic Macular Edema Resistant to Conventional Therapies treatment Not Available terminated NCT00308542
A Study of the Safety and Efficacy of SK-0503 for Diabetic Macular Edema treatment 1 / 2 completed NCT02314299
A Study of MTP-131 Topical Ophthalmic Solution in Subjects With Diabetic Macular Edema and Non-Exudative Intermediate Age-related Macular Degeneration treatment 1 / 2 completed NCT04563299
Effect on Pain and Inflammation With DEXTENZA Treatment in Patients Undergoing Intravitreal Anti-VEGF Injections treatment 4 terminated NCT03466099
Study of the Intravitreal Plasma Kallikrein Inhibitor, KVD001, in Subjects With Center-involving Diabetic Macular Edema (ciDME) No drug interventions treatment 2 completed NCT05416099
Comparing Conventional Grid Laser Photocoagulation and Subthreshold Micropulse Laser in Diabetic Macular Edema Using OCT Angiography No drug interventions Not Available Not Available unknown_status NCT03157206
Diabetic Retinopathy Assessed by Ultra-wide No drug interventions Not Available Not Available unknown_status NCT01698749
Effect of Intravitreal Long Acting Dexamethasone Implant, Ozurdex in Patients With Diabetic Macular Edema treatment Not Available completed NCT02299336
Long-Term Efficacy & Safety of Aflibercept IVT for the Treatment of DME in Subjects Who Completed the VISTA-DME Trial treatment 4 completed NCT04254536
Changes in Optical Coherence Tomography Leakage Mapping in Diabetic Macular Edema After Conbercept Treatment No drug interventions Not Available Not Available unknown_status NCT02914613
Safety and Exploratory Efficacy Study of SF0166 for the Treatment of Diabetic Macular Edema (DME) treatment 1 / 2 completed NCT03321513
DRCR.Net Aflibercept vs. Bevacizumab + Deferred Aflibercept for the Treatment of CI-DME treatment 3 completed NCT02530918
Study of DS-7080a for the Treatment of Macular Degeneration treatment 1 completed NCT03927118
Effect of Dexamethasone Implant on Optic Disc No drug interventions Not Available Not Available completed NCT03490318
Effectiveness of Multimodal Imaging for the Evaluation of Retinal Oedema And New vesseLs in Diabetic Retinopathy No drug interventions Not Available Not Available completed NCT00476918
Intravitreal Triamcinolone Acetonide for Diabetic Macular Edema treatment 1 unknown_status NCT02348918
Phase 2 Randomized Clinical Trial of Luminate® as Compared to Avastin® in the Treatment of Diabetic Macular Edema treatment 2 completed NCT05610319
Treat & Extend Versus Fixed Dosing With Faricimab for Management of Diabetic Macular Edema: A Pragmatic, Multi-center, Open-label, Randomized, Controlled Trial treatment 4 recruiting NCT00709319
Evaluation of Vitrectomy for Diabetic Macular Edema No drug interventions Not Available Not Available completed NCT03094819
PROTECT2: Diabetes Care - Eye Exam No drug interventions health_services_research Not Available unknown_status NCT02985619
Bevacizumabe or Triamcinolone for Persistent Diabetic Macular Edema treatment 2 / 3 completed NCT02663141
Randomized Clinical Trial of Intravitreal Bevacizumab Versus Intravitreal Bevacizumab Combined With Losartan in the Treatment of Diabetic Macular Edema treatment 2 completed NCT01318941
Observe the Effectiveness and Safety of Ranibizumab in Real Life Setting Not Available Not Available completed NCT04805541
Detection and Classification of Diabetic Retinopathy From Posterior Pole Images With A Deep Learning Model Not Available Not Available completed NCT04085341
A Depot Formulation of Sunitinib Malate (GB-102) in Subjects With Diabetic Macular Edema and Retinal Vein Occlusion treatment 2 completed NCT06314217
Everads Injector in Suprachoroidal Administration of TA Suspension, for Treatment of Patients With DME No drug interventions other Not Available recruiting NCT02036424
Anti-Vascular Endothelial Growth Factor (Anti-VEGF) Alone Versus Ozurdex Given Every 3 Months for Treatment of Persistent Diabetic Macular Edema treatment 4 completed NCT03384524
Evaluation of Bromocriptine, Metoprolol and Tamsulosin in Eyes With Non-Central DME treatment 1 / 2 withdrawn NCT00853424
A Comparison of Islet Cell Transplantation With Medical Therapy for the Treatment of Diabetic Eye Disease No drug interventions treatment 3 withdrawn NCT01613716
Ozurdex for Diabetic Macular Edema Treated With Pars Plana vitrEctomy and Membrane RemovAl (OPERA Study) treatment 4 completed NCT05745116
Evaluation of Repeated, In-Clinic, Self-Imaging by DME Patients Using the Notal Vision Home OCT No drug interventions Not Available Not Available recruiting NCT02245516
Exploratory Study of KPI-121 Effect on Intra- or Subretinal Fluid Due to Retinal Vein Occlusion/Diabetic Macular Edema treatment Not Available completed NCT00417716
Use of Intravitreal Bevacizumab in Patients With Diffuse Diabetic Macular Edema treatment 3 withdrawn NCT03003416
Efficacy of Ozurdex® in the Treatment of Diabetic Macular Edema (DME) Not Available Not Available completed NCT04063358
Anti-VEGF Intravitreous Injections for Diabetic Macular Edema in Patients Undergoing Cataract Surgery treatment 3 unknown_status NCT01982435
Safety and Efficacy of Ranibizumab for Diabetic Macular Edema treatment 1 / 2 completed NCT00552435
Micropulse 810 Nanomolar (nm), Diode Laser for Diffuse Diabetic Macular Edema No drug interventions treatment 2 unknown_status NCT03126786
Suprachoroidal CLS-TA With Intravitreal Aflibercept Versus Aflibercept Alone in Subject With Diabetic Macular Edema treatment 2 completed NCT00901186
Efficacy and Safety of Ranibizumab (Intravitreal Injections) Versus Laser Treatment in Patients With Visual Impairment Due to Diabetic Macular Edema treatment 2 completed NCT01045239
Micropulse 577 nm Laser Photocoagulation Versus Conventional 532 nm Laser Photocoagulation for Diabetic Macular Oedema No drug interventions treatment 2 unknown_status NCT00682539
Intraocular Anti-VEGF Compared With Intraocular Triamcinolone in Patients With Diabetic Macular Edema treatment 4 completed NCT05271539
Intravitreal Ranibizumab Versus Its Combination With Dexamethasone in The Treatment of Diabetic Macular Edema treatment 3 completed NCT00370422
Bevacizumab Versus Combined Bevacizumab and Triamcinolone for Refractory Diabetic Macular Edema; a Randomized Clinical Trial treatment 3 unknown_status NCT03974425
One Year Results of Switching to Aflibercept for Persistent Diabetic Macular Edema Resistant to Bevacizumab treatment Not Available completed NCT05496530
Custom Needle Preparation for Suprachoroidal Steroid Injection (One Year Results) treatment Not Available unknown_status NCT06179030
Systemic and Local Inflammatory Biomarkers in the Treatment of Refractory Diabetic Macular Edema Not Available Not Available completed NCT04588948
A Pharmacokinetic stuDy of intRavitreal Aflibercept Injection in Vitrectomized and Non-vitrectomized Eyes With Diabetic Macular Edema treatment 2 withdrawn NCT01565148
A Randomized, Multi-center, Phase II Study of the Safety, Tolerability and Bioactivity of Repeated Intravitreal Injections of iCo-007 as Monotherapy or in Combination With Ranibizumab or Laser Photocoagulation in the Treatment of Diabetic Macular Edema (the iDEAL Study) treatment 2 terminated NCT03038048
30g vs 33g Needle for Intravitreal Injections No drug interventions treatment Not Available completed NCT05569148
A Study in Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular Edema to Evaluate the Safety of the Faricimab Prefilled Syringe treatment 3 completed NCT02406157
577nm Micropulse Laser Versus 532nm Subthreshold Laser Photocoagulation for Diabetic Macular Edema No drug interventions treatment Not Available completed NCT06172257
Study of the Efficacy and Safety of OCS-01 Eye Drops in Subjects With Diabetic Macular Edema (DIAMOND-2) treatment 3 recruiting NCT03762226
Influence of Systemic Parameters in Diabetic Macular Edema - LIPSIA Study No drug interventions Not Available Not Available unknown_status NCT02359526
A Pilot Study on the Effect and Safety of Iluvien® in Chronic Diabetic Macular Edema Patients treatment 4 completed NCT00491166
Safety Study of Bromfenac Ophthalmic Solution in Subjects With Diffuse Diabetic Macular Edema (DME) Refractory to Laser treatment 1 unknown_status NCT02645266
Mean Visual Acuity Changes Following Five Injections of Aflibercept treatment Not Available active_not_recruiting NCT01945866
Phase II Combination Steroid and Anti-VEGF for Persistent DME treatment 2 completed NCT02979665
Changes to the Retina Following Anti-VEGF Treatments for Diabetic Macular Edema Not Available Not Available completed NCT06272565
Exploring the Interaction Between Metabolic Disorders and NLPR3 Inflammasome Activation in DR Inflammatory Damage No drug interventions Not Available Not Available not_yet_recruiting NCT01823965
Intravitreal Injections of Ranibizumab With Deferred Laser Grid Laser Photocoagulation for Treatment of Diabetic Macular Edema With Visual Impairment treatment 2 completed NCT06423274
Comparing Artificial Intelligence for Assisted Diagnosis of Diabetic Retinopathy No drug interventions Not Available Not Available not_yet_recruiting NCT02096874
Bevacizumab and Peripheral Retinal Changes on Wide Field Angiography in Diabetic Macular Edema treatment 4 completed NCT05712720
Study to Evaluate the Efficacy and Safety of RZ402 in Diabetic Macular Edema (DME) No drug interventions treatment 2 active_not_recruiting NCT05151731
A Study to Investigate Vamikibart (RO7200220) in Diabetic Macular Edema treatment 2 active_not_recruiting NCT02107131
Performance Assessment Tests in Working Individuals With DME Following Treatment With Ranibizumab treatment 4 completed NCT00229931
Triamcinolone vs. Laser for Diabetic Macular Edema treatment Not Available completed NCT04432831
A Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Participants With Diabetic Macular Edema treatment 3 completed NCT02118831
Systemic Pharmacokinetics Following Intravitreal Injections of Anti-VEGF basic_science 1 / 2 completed NCT04096131
Influence of Cataract Surgery on Early DME The DICAT-II Study No drug interventions Not Available Not Available completed NCT00071773
A Pilot Study of Laser Photocoagulation for Diabetic Macular Edema No drug interventions treatment 2 completed NCT04418427
ADVM-022 Intravitreal Gene Therapy for DME treatment 2 completed NCT00799227
Safety and Efficacy of a New Treatment in Vitrectomized Subjects With Diabetic Macular Edema treatment 2 completed NCT00683176
Effect of Choline Fenofibrate (SLV348) on Macular Edema treatment 2 completed NCT05728476
Microinvasive Pars Plana Vitrectomy Combined ILM Peeling Versus Anti-VEGF Intravitreal Injection for Treatment-naïve Diabetic Macular Edema treatment Not Available recruiting NCT03759860
Laser (Selective Retina Therapy) and Drug Combined Intervention in Clinically Significant Diabetic Macular Edema treatment 4 unknown_status NCT01253694
Ranibizumab as a Rescue Therapy for Diabetic Macular Edema treatment 2 withdrawn NCT00885794
Microperimetry and Optical Coherence Tomography (OCT) With Lucentis for Diabetic Macular Edema (DME) treatment 2 / 3 unknown_status NCT06536491
EC-104 Intravitreal Implant for the Treatment of Diabetic Macular Edema treatment 1 / 2 not_yet_recruiting NCT00997191
Intravitreal Bevacizumab and Triamcinolone Associated to Laser Photocoagulation for Diabetic Macular Edema(IBeTA) treatment 3 completed NCT05727891
Evaluation of Tonabersat for DME treatment 2 recruiting NCT05512962
Oxulumis® Suprachoroidal Microcatherization of Triesence® in Diabetic Macular Edema treatment 2 completed NCT05182580
Bangladesh PRODUCTIVity in Eyecare Trial No drug interventions diagnostic Not Available completed NCT05526729
Special Drug Use Observational Study With Beovu Kit for Intravitreal Injection No drug interventions Not Available Not Available completed NCT05990829
Compare the Efficacy of VItrectomy Combined With DExamethasone Implant Versus With Aflibercept in DME Patients Diagnosed by Intraoperative OCT (the VIDEO Study): Study Protocol for a Randomized Controlled Trial treatment 4 recruiting NCT02088229
Relating Retinal Structural and Functional Parameters to Visual Acuity in Eyes Undergoing Treatment for Diabetic Macular Edema No drug interventions Not Available Not Available completed NCT00989989
Efficacy and Safety of Ranibizumab (Intravitreal Injections) in Patients With Visual Impairment Due to Diabetic Macular Edema treatment 3 completed NCT00168389
A Study of the Safety and Efficacy of a New Treatment for Diabetic Macular Edema treatment 3 completed NCT05731089
IVI Aflibercept Before and After Phaco in DME. No drug interventions treatment Not Available completed NCT00536692
Topical Ocular Mecamylamine in Diabetic Macular Edema (DME) treatment 2 completed NCT01355692
Evaluation of the Effects of Selective Photocoagulation for the Treatment of Diabetic Macular Edema No drug interventions treatment 2 / 3 completed NCT05324592
Safety and Efficacy of 9MW0813 in Subjects With Diabetic Macular Edema treatment 1 completed NCT00846092
Near-infrared Light (NIR) Therapy for Diabetic Macular Edema: A Pilot Study No drug interventions treatment 1 completed NCT03143192
Treatment of Diabetic Macular Edema With Aflibercept and Micropulse Laser No drug interventions treatment 2 / 3 completed NCT02281292
A Study of the Safety and Tolerability of Intravitreal LKA651 in Patients With Diabetic Macular Edema treatment 1 withdrawn NCT01845844
Ranibizumab For Persistent Diabetic Macular Edema After Bevacizumab treatment 1 / 2 unknown_status NCT01487044
A Single-Center Trial of High Frequency Pegaptanib for Rapid Restoration of VEGF Levels in Diabetic Retinal Edema Not Available Not Available available NCT02308644
Intravitreous Bevacizumab and Standard Metabolic Control for Diabetic Macular Edema - A Contrast Sensitivity Study treatment 3 completed NCT00874744
Comparison of Single Intravitreal Injection of Triamcinolone or Bevacizumab for the Treatment of Diabetic Macular Edema treatment 2 completed NCT05151744
A Study to Investigate Vamikibart (RO7200220) in Combination With Ranibizumab in Diabetic Macular Edema treatment 2 active_not_recruiting NCT00759044
Validation of a New Methodology for Mapping the Human Blood-Retinal Barrier Function No drug interventions Not Available Not Available completed NCT03641144
Navigation Laser Versus Traditional Laser Photocoagulation for Mild Diabetic Macular Edema No drug interventions treatment Not Available unknown_status NCT02503540
Peripheral and Macular Retinal Vascular Perfusion and Leakage in DME and RVO treatment 4 completed NCT02511067
Ranibizumab for Edema of the mAcula in Diabetes: Protocol 4 With Tocilizumab: The READ-4 Study treatment 2 withdrawn NCT05172401
Oxulumis®, Suprachoroidal Drug Administration of Triesence® in Diabetic Macular Edema No drug interventions treatment Not Available withdrawn NCT03345901
PROMINENT-Eye Ancillary Study (Protocol AD) prevention 3 terminated NCT00105404
Treatment of Diabetic Macular Edema: Triamcinolone Injections Vs. Laser Photocoagulation treatment 3 completed NCT04387604
Effect of the Vitreous in Response to Intravitreal Injections of Ranibizumab for the Treatment of Diabetic Macular Edema Not Available Not Available completed NCT00687804
A 12 Month Core Study to Assess the Efficacy and Safety of Ranibizumab (Intravitreal Injections) in Patients With Visual Impairment Due to Diabetic Macular Edema and a 24 Month Open-label Extension Study treatment 3 completed NCT00306904
Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema treatment 2 completed NCT02297204
The Endurance 1 Trial prevention 4 completed NCT05959304
Post Marketing Study to Evaluate the Safety and Effectiveness of Brolucizumab in Patients With Diabetic Macular Edema. No drug interventions Not Available Not Available not_yet_recruiting NCT01573572
Extension Study to Gather Data on Effect of Macugen on the Corneal Endothelium other 4 completed NCT03917472
Efficacy and Safety of Brolucizumab vs Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema treatment 3 completed NCT02651168
Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Patients With Persistent Diabetic Macular Edema Following Treatment With Ranibizumab: An Interventional Prospective Study treatment 4 unknown_status NCT06449768
Effectiveness Of Suprachoroidal Injection In Diabetic Macular Edema No drug interventions Not Available Not Available active_not_recruiting NCT00344968
Fluocinolone Acetonide Implant Compared to Sham Injection in Patients With Diabetic Macular Edema treatment 3 completed NCT01324869
Safety and Efficacy by Multiple Injection of KH902 in Patients With Diabetic Macular Edema (DME) No drug interventions treatment 1 / 2 completed NCT04087746
Comparison of Aflibercept Versus Ranibizumab in Management of Diabetic Macular Edema (DME) treatment 4 completed NCT03610646
Comparative Study to Evaluate the Efficacy and Safety of MYL-1701P and Eylea® in Subjects With Diabetic Macular Edema (DME) treatment 3 completed NCT05683912
Aflibercept for Diabetic Macular Edema In Real-life Practice in GREece Not Available Not Available completed NCT02443012
Topical Nepafenac as Supplement for Diabetic Macular Edema treatment 4 completed NCT00371410
Sequentially Combined Vitrectomy, IVTA and Macular Focal Laser Photocoagulation for Diabetic Macular Edema treatment 1 completed NCT01472510
Ranibizumab in Residual Diabetic Macular Edema Following Previous Anti-VEGF Therapy treatment 2 completed NCT03629210
Combination OZURDEX® & EyLea® vs. OZURDEX® Monotherapy in IncompLete-Responders wIth Diabetic Macular Edema treatment 2 withdrawn NCT05607810
Long-Term Follow-up Study of ADVM-022 in DME (INFINITY-EXT) No drug interventions Not Available Not Available enrolling_by_invitation NCT00407381
The Ranibizumab for Edema of the mAcula in Diabetes-2 (READ-2) Study treatment 2 completed NCT03453281
Early Anatomical, Physiological, and Clinical Changes in Diabetic Macular Edema After Intravitreal Aflibercept Injection treatment 4 completed NCT01947881
Characterization of Eyes With Diabetic Macular Edema That Show Different Treatment Response to Intravitreal Anti-VEGF (CHARTRES) No drug interventions Not Available Not Available completed NCT01141881
Evaluation of the Role of Intravitreal Tissue Plasminogen Activator in Treatment of Refractory Diabetic Macular Edema treatment Not Available terminated NCT01732614
Topcon Endpoint Management No drug interventions treatment Not Available completed NCT00320814
Phase 1 Study of VEGF Trap in Patients With Diabetic Macular Edema No drug interventions treatment 1 completed NCT06491914
A Single-Arm Study of Aflibercept 8 mg Dosed in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD) or Diabetic Macular Edema (DME) treatment 3 recruiting NCT05333055
Aqueous Biomarker Levels in Diabetic Retinopathy and Diabetic Macular Edema No drug interventions Not Available Not Available unknown_status NCT00994955
Selective Retina Therapy (SRT) for Clinically Significant Diabetic Macular Edema No drug interventions treatment 1 / 2 completed NCT00801450
Intravitreal Injection Versus Sub-Tenon's Infusion of Triamcinolone Acetonide for Refractory Diabetic Macular Edema During Cataract Surgery treatment 1 / 2 unknown_status NCT00284050
Safety and Efficacy of Ranibizumab in Diabetic Macular Edema With Center Involvement treatment 2 completed NCT01572350
Safety and Efficacy of Triamcinolone Acetonide Combined With Laser, Bevacizumab Combined With Laser Versus Laser Alone for the Treatment of Diffuse Non-tractional Diabetic Macular Edema treatment 3 completed NCT03690050
A Comparison of Standard Laser With Micropulse Laser for the Treatment of Diabetic Macular Oedema. No drug interventions treatment Not Available completed NCT04991350
Effect of Ranibizumab Versus Bevacizumab on the Macular Perfusion in Diabetic Macular Edema treatment 4 terminated NCT02556723
Intravitreal Injections of Ziv-aflibercept for Macular Diseases treatment Not Available completed NCT05368623
Validation Study of RETINA-AI Galaxy™ v2.0, an Automated Diabetic Retinopathy Screening Device No drug interventions Not Available Not Available completed NCT06549023
Single Session vs Multiple-Session Panretinal Photocoagulation for Treatment of Proliferative Diabetic Retinopathy No drug interventions treatment Not Available not_yet_recruiting NCT01552408
Efficacy & Safety Trial of Intravitreal Injections Combined With PRP for CSME Secondary to Diabetes Mellitus (DAVE) treatment 1 / 2 completed NCT02712008
Anti-vasculaR Endothelial Growth Factor plUs Anti-angiopoietin 2 in Fixed comBination therapY: Evaluation for the Treatment of Diabetic Macular Edema treatment 2 completed NCT01486238
Pegaptanib for Retinal Edema Secondary to Diabetic Vascular Disease(Preserve) Study treatment 4 completed NCT03973138
Visual Outcomes and the Predictive Factors in Chinese Patients With Diabetic Macular Edema Treated With Ranibizumab treatment 1 / 2 unknown_status NCT05511038
A Study to Learn How Safe the Study Drug Intravitreal (Given by an Injection Into the Eye) Aflibercept is in Participants in India With Diabetic Macular Edema treatment 4 completed NCT04776343
Study Comparing Two Populations of Patients Treated With Anti VEGF for Diabetic Macular Edema, One Being Followed at the Hospital and the Other One Being Followed at Home Using a Software Allowing Self-assessment of Visual Acuity No drug interventions diagnostic Not Available unknown_status NCT00656643
Dose Ranging Study of an Ocular Sirolimus (Rapamycin) Formulation in Patients With Diabetic Macular Edema treatment 2 completed NCT04187443
MS-553 in Diabetic Retinopathy Patients With Central Involved Macular Edema No drug interventions treatment 1 suspended NCT04619303
Intravitreal Dexamethasone vs Bevacizumab in Aboriginal People With DMO treatment 4 completed NCT05885503
Efficacy and Safety of RC28-E Versus Aflibercept in Diabetic Macular Edema treatment 3 recruiting NCT02870803
OCT-angiography in Diabetic Patients No drug interventions Not Available Not Available unknown_status NCT00445003
Laser-Ranibizumab-Triamcinolone for Proliferative Diabetic Retinopathy treatment 3 completed NCT03918590
Post Intravitreal Injection Topical NSAID vs. Patching treatment 4 unknown_status NCT06332690
OCT and OCT-Angiography Biomarkers of Treatment Response to Dexamethasone Implant in Macular Edema Due to Retinal Vascular Diseases - DME and RVO No drug interventions Not Available Not Available recruiting NCT04142164
Computer-based Tutorial and Automated Speech Recognition for Intravitreal Drug Injections No drug interventions other Not Available unknown_status NCT02392364
Variable Interval Versus Set Interval Aflibercept for DME treatment 4 completed NCT01997164
Study of Intravitreal (IVT) REGN910-3 and IVT REGN910 in Patients With Either Neovascular ("Wet") Age Related Macular Degeneration (AMD) or Diabetic Macular Edema (DME) basic_science 1 completed NCT02000102
Outcomes of Diabetic Macula Edema Patients Switched to Aflibercept From Bevacizumab and/or Ranibizumab Not Available Not Available completed NCT01441102
Dextromethorphan for Diabetic Macular Edema treatment 1 / 2 completed NCT05224102
A Study to Investigate Faricimab Treatment Response in Treatment-Naive, Underrepresented Patients With Diabetic Macular Edema treatment 4 recruiting NCT03297684
Assessment of Biomarker Profile in Diabetic Macular Edema With Intravitreal Aflibercept Injection Not Available Not Available unknown_status NCT06099184
Study of EYP-1901 in Patients With Diabetic Macular Edema (DME) treatment 2 not_yet_recruiting NCT02684084
Combination OZURDEX® & LUCENTIS® vs. OZURDEX® Monotherapy in Incomplete-Responders With Diabetic Macular Edema treatment 4 terminated NCT06205979
Relationship Between Dyslipidemia and The Response of Diabetic Macular Edema to Intravitreal Injection of Anti Vascular Endothelial Growth Factor Agents treatment 0 recruiting NCT03832179
Steroid vs. Anti-vascular Endothelial Growth Factor for Diabetic Macular Edema Prior to Phacoemulsification treatment 4 unknown_status NCT03056079
Cytokine and Visual Outcome Variations in Eyes Receiving Aflibercept treatment 4 unknown_status NCT02302079
A Study to Evaluate ASP8232 in Reducing Central Retinal Thickness in Subjects With Diabetic Macular Edema (DME) treatment 2 completed NCT01748487
The Effect of Intravitreal Ozurdex on DME After Cataract Surgery prevention 3 completed NCT03590587
Rapid Structural and Functional Improvements in Following 0.19 mg Fluocinolone Acetonide (FAc) Implant in Diabetic Macular Edema Patients With Poor Visual Acuity: 12-month Audit Results From United Arab Emirates Not Available Not Available unknown_status NCT04332133
Outcomes of Subthreshold Laser Versus Intravitreal Injection of Ranibizumab in Diabetic Macular Edema No drug interventions treatment Not Available completed NCT00367133
Intravitreal Triamcinolone Acetonide Versus Laser for Diabetic Macular Edema treatment 3 completed NCT04018833
Intravitreal Ranibizumab or Aflibercept After Bevacizumab in Diabetic Macular Edema Not Available Not Available completed NCT05222633
Anti-VEGF in Real-world Not Available Not Available unknown_status NCT02634333
Anti-VEGF Treatment for Prevention of PDR/DME prevention 3 completed NCT00687154
Observational Study of DME Following Scatter Laser Photocoagulation No drug interventions prevention Not Available completed NCT01928654
Comparison Between Treatment With Yellow Micropulse Laser and Green Conventional Laser in Diabetic Macular Edema No drug interventions treatment Not Available unknown_status NCT01411254
Efficacy and Safety of Betamethasone Microsphere in Patients With Diabetic Macular Edema (TSUBASA) Not Available 2 / 3 completed NCT01309451
Ozurdex as Adjunct to Avastin Compared to Avastin Alone in Treatment of Patients With Diabetic Macular Edema treatment 4 completed NCT01473251
Analysis of Growth Factors in Patients Undergoing Lucentis or Avastin Injections for Diabetic Macular Edema and Exudative Macular Degeneration health_services_research Not Available completed NCT00468351
Intravitreal Triamcinolone Acetonide Versus Intravitreal Bevacizumab for Refractory Diabetic Macular Edema (IBEME Study) No drug interventions treatment 1 unknown_status NCT02471651
Dexamethasone Intravitreal Implant for the Treatment of Persistent Diabetic Macular Edema treatment 4 completed NCT05966753
Describing Patient With DME, Their Patient Journey and Disease Progression No drug interventions Not Available Not Available completed NCT04544553
Barriers to Eye Screening for People With Diabetes in India No drug interventions screening Not Available completed NCT01821677
A Safety and Efficacy Study of Oral Danazol (a Previously Approved Drug) in the Treatment of Diabetic Macular Edema. treatment 2 completed NCT05582577
Additional Effect of Subthreshold Micropulse Laser to Intravitreous Injection of Bevacizumab on Diabetic Macular Edema treatment 2 / 3 active_not_recruiting NCT03059277
Intravitreal Alfibercept for Center Involved DME Previously Managed With Intravitreal Ranibizumab treatment 4 withdrawn NCT06237777
A Clinical Study Evaluating the Safety, Tolerability and Initial Efficacy of SKG0106 Intravitreal Injection in Diabetic Macular Edema (DME) Patients No drug interventions treatment 1 recruiting NCT00789477
DME And VEGF Trap-Eye [Intravitreal Aflibercept Injection (IAI;EYLEA®;BAY86-5321)] INvestigation of Clinical Impact treatment 2 completed NCT00505947
Treatment of Refractory Diabetic Macular Edema With Infliximab treatment 3 terminated NCT03690947
Combination of Intravitreal Ranibizumab With or Without Micropulse Laser for the Treatment of DME treatment 4 completed NCT02637245
Imaging Parameters and DME Treatment Response No drug interventions Not Available Not Available completed NCT05752045
OphtAI Diagnostic Performance Validation for Automated Screening of Eye Diseases No drug interventions screening Not Available recruiting NCT03694145
Predicting Diabetic Retinopathy From Risk Factor Data and Digital Retinal Images No drug interventions Not Available Not Available active_not_recruiting NCT01790945
Diabetic Macular Edema and Diabetic Retinopathy Screening (TeleMed) With Automated Retinal Photography No drug interventions Not Available Not Available unknown_status NCT03511898
A Study to Evaluate the Safety of THR-149 in Subjects With Diabetic Macular Edema (DME) No drug interventions treatment 1 completed NCT01292798
Ranibizumab 0.5mg and 2.0mg to Treat Diabetic Macular Edema in Patients With Poor Response to Bevacizumab treatment 1 / 2 completed NCT04116398
Pilot and Phase 2 Study of the Efficacy of a Treatment Protocol With Dexamethasone Implant Loading Dose in Patients With Diabetic Macular Edema (LOADEX) treatment 2 recruiting NCT04089605
Ranibizumab vs Dexamethasone Implant in Vitrectomized Eyes With Diabetic Macular Edema treatment 4 completed NCT03956797
Long Term Safety of Cooling Anesthesia for Intravitreal Injection No drug interventions treatment Not Available completed NCT02121197
Retrospective Trial on the Efficacy and Safety of Intravitreal Ozurdex in Patients With Diabetic Macular Edema. Not Available Not Available completed NCT01875783
OCT Screening for Diabetic Macular Edema at Primary Diabetes Care Visits No drug interventions diagnostic Not Available completed NCT05112861
A 3-month Study to Compare the Safety of ONS-5010 in Vials Versus Pre-filled Syringe in Subjects With Visual Impairment Due to Retinal Disorders treatment 3 active_not_recruiting NCT05940428
A Study of ASKG712 in Patients With Diabetic Macular Edema No drug interventions treatment 1 not_yet_recruiting NCT02055911
Retinal Ganglion Cell Function After Intravitreous Ranibizumab in Patients With Diabetic Macular Edema treatment 4 withdrawn NCT04411693
Comparative Study of Dexamethasone Implant to Intravitreal Aflibercept in Subjects With Diabetic Macular Edema treatment 4 completed NCT03622593
A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema treatment 3 completed NCT01640171
Anesthesia Preference for Intravitreal Injection: Topical or Subconjunctival treatment Not Available completed NCT02325271
Intra-individual Variability and Circadian Rhythm of VEGF Levels and Interaction With Biomarkers No drug interventions Not Available Not Available completed NCT01284478
Ozurdex for Combined Pseudophakic Cystoid Macular Edema and Diabetic Macular Edema After Cataract Surgery treatment 2 completed NCT03920878
Cataract DME - Peri vs. Intraop treatment 2 withdrawn NCT01042678
Study of MP0112 Intravitreal Injection in Patients With Diabetic Macular Edema No drug interventions treatment 1 terminated NCT03533478
Alzer® and Diamel® to Prevent Severe Diabetes Macular Edema No drug interventions prevention 2 completed NCT05847088
Intravitreal Dexamethasone Implant for Refractory Diabetic Macular Edema: Not Available Not Available completed NCT06316388
Outcomes After Vitrectomy in Eyes With Tractional Diabetic Macular Edema No drug interventions Not Available Not Available not_yet_recruiting NCT04692688
Study of the Safety and Efficacy of APX3330 in Diabetic Retinopathy treatment 2 completed NCT02441907
Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Diabetic Macular Edema treatment 4 completed NCT03475407
The Effects of Intravitreal Ozurdex Implant in DME treatment 4 unknown_status NCT04151407
The Study of Drug 601 in Patients With Diabetic Macular Edema (DME) No drug interventions treatment 1 unknown_status NCT06422507
A Study to Learn More About How Well 8 Milligram Aflibercept Works and How Safe it is in Chinese Participants With Diabetic Macular Edema treatment 3 recruiting NCT03953807
A Study to Evaluate the Effectiveness and Safety of OZURDEX® in Patients With Diabetic Macular Edema But Never Treated treatment 4 completed NCT01259609
Changes in Ciliary Body Thickness in Patients With Diabetic Macular Edema After Vitrectomy No drug interventions diagnostic Not Available completed NCT04014556
Aflibercept Plus Micropulse Laser Versus Aflibercept Monotherapy for Diabetic Macular Edema treatment Not Available completed NCT05715385
Comparison of Treatments in Diabetic Macular Edema treatment 4 completed NCT02510885
SD-OCT Angiography No drug interventions other Not Available terminated NCT01112085
MIcrodoses of raNIbizumab in Diabetic MAcular Edema (MINIMA-2) treatment 2 completed NCT04782115
Evaluation of RC28-E Injection in Diabetic Macular Edema treatment 2 completed NCT03597815
Diabetic Macular Edema - Obstructive Sleep Apnea Relationship Study Not Available Not Available unknown_status NCT04795037
First-In-Human Study of CU06-1004 Following Single and Multiple Ascending Doses in Healthy Volunteers No drug interventions treatment 1 completed NCT06262737
Single-center Study Measuring OSDI Dry Eye Score in Patients Undergoing an Anti-VEGF Induction Protocol No drug interventions Not Available Not Available recruiting NCT02329132
Change Oxygen Consumption Following Intravitreal Treatment of Lucentis (Ranibizumab) in Eyes With Diabetic Macular Edema Not Available Not Available completed NCT01571232
Ozurdex for Treatment of Recalcitrant Diabetic Macular Edema treatment 2 completed NCT03783832
Follow up of Diabetic Macular Edema Treated by Aflibercept (Eylea®) With OCT-Angiography No drug interventions Not Available Not Available unknown_status NCT03161652
Effect of Levosulpiride on Retinal Alterations in Patients With Diabetic Retinopathy and Diabetic Macular Edema treatment 2 recruiting NCT03246152
Evaluation of the Effect of Intravitreal Injections of Anti-VEGF on Macular Perfusion in Diabetic Patients Using OCTA treatment 4 completed NCT04468152
Advanced Glycation End Products Are Associated With Diabetic Macular Edema No drug interventions screening Not Available completed NCT00133952
Effect of Ruboxistaurin on Clinically Significant Macular Edema treatment 3 completed NCT06511700
Implementation of the Intravitreal Injection Administered by Nurses No drug interventions Not Available Not Available not_yet_recruiting NCT05573100
The Study of CU06-1004 in Patients With Diabetic Macular Edema (DME) No drug interventions treatment 2 completed NCT04674800
Extension Study of MYL-1701P-3001 for Safety and Efficacy treatment 3 completed NCT01788475
Safety and Effectiveness of Ozurdex Steroid Implants for DME After Vitrectomy Surgery treatment Not Available terminated NCT00545870
Bevacizumab Versus Ranibizumab for Diabetic Retinopathy treatment 3 completed NCT03583242
Multimodal Image Study of Retinal Inflammation Markers After Corticoid and Antiangiogenic Treatment in Pacients With Diabetic Macular Edema No drug interventions Not Available Not Available unknown_status NCT01445899
PF-04523655 Dose Escalation Study, and Evaluation of PF-04523655 With/Without Ranibizumab in Diabetic Macular Edema (DME) treatment 2 completed NCT04455399
Time Efficiency Comparison of Two IntraVitreal Injection Techniques No drug interventions treatment Not Available completed NCT01769599
Comparison of Initial Treatment in With Laser Grid in Diabetic Macular Edema to Intra Vitreal Avastin Injections No drug interventions Not Available Not Available unknown_status NCT01120899
A Pilot Study for the Evaluation of Minocycline as a Microglia Inhibitor in the Treatment of Diabetic Macular Edema treatment 1 / 2 completed NCT04505306
Short-pulse Subthreshold vs Infrared Micropulse for Diabetic Macular Edema No drug interventions treatment Not Available completed NCT01304706
Fluocinolone Acetonide in Diabetic Macular Edema (FAME) Extension Study treatment 3 completed NCT00665106
Safety and Tolerability of NOVA63035 "Corticosteroid" in Patients With Diabetic Macular Edema Secondary to Diabetic Retinopathy supportive_care 1 completed NCT01627249
Comparative Effectiveness Study of Intravitreal Aflibercept, Bevacizumab, and Ranibizumab for Diabetic Macular Edema treatment 3 completed NCT04935749
Epidemiologic Assessment of Diabetic Retinopathy in Egypt Using Ultrawide Field Fundus Photographs No drug interventions Not Available Not Available recruiting NCT00040313
Pegaptanib Sodium Compared to Sham Injection in Patients With DME Involving the Center of the Macula treatment 2 completed NCT02193113
A Phase I Single Ascending Dose Study of the Intravitreal Plasma Kallikrein Inhibitor KVD001 in Subjects With DME No drug interventions treatment 1 completed NCT04648618
Obstructive Sleep Apnea and Diabetic Macular Edema Inflammatory Mediators No drug interventions Not Available Not Available unknown_status NCT05489718
A Dose Escalation Study of IBI324 in Subjects With Diabetic Macular Edema No drug interventions treatment 1 completed NCT04597918
A Study to Investigate Aqueous Humor and Multimodal Imaging Biomarkers in Treatment-Naïve Participants With Diabetic Macular Edema Treated With Faricimab treatment 2 completed NCT02842541
Safety Study of Intravitreal EBI-031 Given as a Single or Repeat Injection to Subjects With Diabetic Macular Edema treatment 1 withdrawn NCT00502541
Efficacy of Fluocinolone Acetonide Intravitreal Implant in Diabetic Macular Edema treatment 2 / 3 completed NCT02194634
Safety and Efficacy Study of Conbercept in Diabetic Macular Edema (DME) (Sailing) treatment 3 unknown_status NCT02645734
The Effect of Bevacizumab and Ziv-aflibercept in Diabetic Macular Edema treatment 2 / 3 unknown_status NCT05063734
A Study to Evaluate THR-687 Treatment for Diabetic Macular Oedema. treatment 2 terminated NCT03481634
Study of Efficacy and Safety of Brolucizumab vs. Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema treatment 3 completed NCT02949024
Suprachoroidal Injection of CLS-TA Alone or With Aflibercept in Subjects With Diabetic Macular Edema treatment 1 / 2 completed NCT00893724
Supplemental Adjuvants for Intracellular Nutrition and Treatment treatment Not Available unknown_status NCT06305416
A Efficacy and Safety Study of Ranibizumab 10mg/ml Injection (Incepta) in Patients With Diabetic Macular Edema treatment 3 recruiting NCT06213896
Detecting Eye Diseases Via Hybrid Deep Learning Algorithms From Fundus Images Not Available Not Available completed NCT01358396
Glycemic Control and Diabetic Macular Edema No drug interventions Not Available Not Available completed NCT01168258
Evaluation of Single Nucleotide Polymorphisms (SNPs) in Patients With and Without Diabetic Macular Edema No drug interventions Not Available Not Available terminated NCT03240458
Screening For Diabetic Macular Edema Among Diabetic Patients Using Optical Coherence Tomography No drug interventions Not Available Not Available unknown_status NCT02867735
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Activity of Intravitreal LKA651 in Patients With Macular Edema No drug interventions treatment 1 completed NCT01892163
Multicentre Randomised Clinical Trial Comparing Fixed vs Pro re Nata (PRN) Dosing of 700 μg Dexamethasone No drug interventions treatment 3 completed NCT00369863
A Randomized, Placebo-Controlled Clinical Trial of Intravitreal Triamcinolone for Refractory Diabetic Macular Edema treatment 2 completed NCT01899963
Time to Treatment Utilizing a Tele-Retinal Referral System for wAMD and DME: A Pilot Study No drug interventions Not Available Not Available completed NCT00369486
A Pilot Study of Peribulbar Triamcinolone Acetonide for Diabetic Macular Edema treatment 2 completed NCT03608839
Effect of Dexamethasone on Reduction of Macular Thickness in Diabetic Patients, a Randomized Clinical Trial treatment 2 completed NCT04774822
Validation Study of RETINA-AI Galaxy™, an Automated Diabetic Retinopathy Screening Device No drug interventions Not Available Not Available completed NCT05978622
Observational Study of Adult Participants With Diabetic Macular Edema and Suboptimal Response to Anti-Vascular Endothelial Growth Factor Treated With Dexamethasone Intravitreal Implant No drug interventions Not Available Not Available recruiting NCT05127525
EffiCacy, Safety and ToLErability of a Novel Ocular ANtiseptic for Ocular Use (CLEAN) No drug interventions treatment 3 terminated NCT01196325
Anterior and Posterior Segment Vascular Changes Following Laser and Anti-Vascular Endothelial Growth Factor (VEGF) Treatment of Diabetic Retinopathy No drug interventions Not Available Not Available unknown_status NCT02614625
Spectral-domain Optical Coherence Tomography of the Eye No drug interventions Not Available Not Available unknown_status NCT00959725
Pilot Study for the Evaluation of Intravitreal Infliximab in the Treatment of Diabetic Macular Edema treatment 1 / 2 unknown_status NCT04038125
Increase in Capillary Plexus Density Level Following the Use of Ozurdex for the Treatment of DME treatment 4 unknown_status NCT01610557
Ranibizumab and Bevacizumab for Diabetic Macular Edema treatment 2 completed NCT05476926
A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products Not Available Not Available recruiting NCT01951066
Diabetic Macular Edema Treated With Ozurdex (DMEO) Not Available 2 completed NCT05861466
Comparative Study Between IVI of Ranibizumab With and Without Prior ACP in Patients With DME Using OCT-A supportive_care 4 recruiting NCT05324774
Efficacy and Safety of 9MW0813 in Subjects With Diabetic Macular Edema treatment 3 unknown_status NCT01934920
Identifying Patients With Unrecognized Treatable Diabetic Macular Edema No drug interventions Not Available Not Available unknown_status NCT00387582
Efficacy Study of Lucentis in the Treatment of Diabetic Macular Edema treatment 2 completed NCT04018482
Povidone Iodine vs AVEnova: A Pre-injection Disinfection Study (PAVE Study) No drug interventions treatment 4 completed NCT03385382
Ranibizumab Versus Dexamethasone Implant in Diabetic Macular Edema Not Available Not Available completed NCT03394573
Comparison of VA Guided Versus OCT Guided TER Using Aflibercept for Diabetic Macular Edema (AVOCT Study) No drug interventions Not Available Not Available terminated NCT03866473
A Pilot Study Evaluating Photobiomodulation Therapy for Diabetic Macular Edema No drug interventions treatment Not Available completed NCT06181227
A Phase 2 Study of Intravitreal AVD-104 in Diabetic Macular Edema No drug interventions treatment 2 terminated NCT01171976
Efficacy and Safety of Ranibizumab in Two "Treat and Extend" Treatment Algorithms Versus Ranibizumab As Needed in Patients With Macular Edema and Visual Impairment Secondary to Diabetes Mellitus treatment 3 completed NCT06492876
Gene Therapy for DME No drug interventions treatment 1 / 2 recruiting NCT06439576
Real World Evidence in China: Faricimab Use in Diabetic Macular Edema, Retinal Vein Occlusion, and Neovascular Age-Related Macular Degeneration (The Farseeing Study) Not Available Not Available recruiting NCT05472376
Real-Life Study in Diabetic Macular Edema No drug interventions Not Available Not Available completed NCT03481660
A Study of the Efficacy and Safety of Brolucizumab vs. Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema treatment 3 completed NCT00815360
Ranibizumab and Peripheral Scatter Laser in Patients With Diabetic Macular Edema and Peripheral Nonperfusion treatment 2 completed NCT02262260
Compare Safety/Efficacy of Labeled vs Wait-Extend Regimen of Lucentis in Turkish Patients With VI Due to DME No drug interventions treatment 3 completed NCT04464694
Pre-vitrectomy Intravitreal Ranibizumab for Patients With Proliferative Diabetic Retinopathy Combined With Diabetic Macular Edema treatment 4 unknown_status NCT05099094
VEGFA-targeting Gene Therapy to Treat Retinal and Choroidal Neovascularization Diseases No drug interventions treatment 0 unknown_status NCT01510691
Vitrectomy Retinal Oxygenation No drug interventions Not Available Not Available withdrawn NCT05916391
Gene Therapy for Diabetic Macular Edema No drug interventions treatment 1 recruiting NCT01909791
Treatment for CI-DME in Eyes With Very Good VA Study treatment 3 completed NCT05217680
Clinical Study to Evaluate PRO-169 for Diabetic Macular Edema treatment 3 recruiting NCT03622580
A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema (YOSEMITE) treatment 3 completed NCT00780780
Efficacy Study of Triamcinolone Associated With Nepafenac for Treatment of Diabetic Macular Edema treatment 3 completed NCT03197480
Diabetic Macular Edema Asian Response (DEAR) Study: Biomarkers for Response to Aflibercept in Asian Patients With Center Involving DME treatment 4 unknown_status NCT05698329
Effect of AIV007 by Periocular Administration in Subjects With nAMD or DME No drug interventions treatment 1 recruiting NCT05802329
Phase I Study to Assess the Safety and Efficacy of OCU200 for Center-Involved Diabetic Macular Edema (DME) No drug interventions treatment 1 not_yet_recruiting NCT05083689
Combined Intravitreal Bevacizumab With Topical Timolol-Dorzolamide Eye Drops in Diabetic Macular Edema treatment 2 / 3 unknown_status NCT03056092
Cytokine and Visual Outcome Variations in Eyes Receiving Ranibizumab treatment 4 unknown_status NCT00764244
Laser Versus Vitrectomy Versus Intravitreal Triamcinolone Injection for Diabetic Macular Edema treatment 3 completed NCT02902744
Fluocinolone Acetonide Insert (ILUVIEN®) for Diabetic Macular Edema (FAD) Study treatment 4 withdrawn NCT03889444
Chart Review: Drug Utilization Study in Participants Who Received Ozurdex™ (Dexamethasone Intravitreal Implant) 0.7 mg Injections for Visual Impairment Due to Diabetic Macular Edema (DME) Not Available Not Available completed NCT00768040
Efficacy of Aliskiren in the Treatment of Diabetic Macular Edema treatment 2 terminated NCT05675540
Artificial Intelligence Diagnostic Aid No drug interventions Not Available Not Available not_yet_recruiting NCT01363440
Study of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) in Patients With Diabetic Macular Edema treatment 3 completed NCT00563940
Short-term Effects of Intravitreal Bevacizumab and Triamcinolone in Patients With Diabetic Macular Edema No drug interventions Not Available Not Available completed NCT04058067
To Compare Brolucizumab to Aflibercept in Chinese Patients With Visual Impairment Due to Diabetic Macular Edema treatment 3 completed NCT01077401
Ranibizumab for Edema of the Macula in Diabetes: Protocol 3 With High Dose - the READ 3 Study treatment 2 completed NCT03384901
The Results of Pars Plana Vitrectomy in Diabetic Macular Edema No drug interventions Not Available Not Available unknown_status NCT02337972
Conjunctival Flora Patterns After Serial Intravitreal Injections in Diabetic Patients diagnostic Not Available unknown_status NCT02059772
Combination of Standard Lucentis Therapy With Micropulse Diode Laser for the Treatment of Diabetic Macular Edema treatment 4 unknown_status NCT02571972
Dorzolamide-timolol Drops With Injections to Treat AMD, RVO or DME. treatment 2 completed NCT03097068
Analysis of Cytokines in Response to Treatment of Diabetic Macular Edema With 0.3mg Lucentis basic_science 4 completed NCT06548568
A Real-world Study to Assess Safety of OZURDEX® (Dexamethasone Intravitreal Implant) in Adult Participants With Diabetic Macular Edema in China No drug interventions Not Available Not Available not_yet_recruiting NCT01297569
Ranibizumab "Treat and Extend" in Diabetic Macular Edma treatment 4 completed NCT00370669
Effect of Intravitreal Bevacizumab on Clinically Significant Macular Edema treatment 3 unknown_status NCT02448446
The Effect of Intravitreal Ranibizumab on Visual Acuity and Hard Exudate Resolution in the Treatment of Diabetic Macular Edema With Center Involved Edema and Lipid Exudates treatment 1 / 2 completed NCT03866746
Aflibercept With and Without Micropulse Laser in Diabetic Macular Edema treatment 4 completed NCT01661946
Bloodstream Absorption of Avastin and Lucentis After Injection Into the Eye other 3 completed NCT05815212
Ranibizumab 0.5 mg for Diabetic Macular Edema With Initial Intensive Treatment in the Real World Clinical Setting in Korea (Rising K) No drug interventions Not Available Not Available completed NCT03340610
IAI for Persistent DME After Treatment With Bevacizumab And Ranibizumab treatment 4 completed NCT03984110
One Year Trial Evaluating Safety of Ozurdex With Eylea treatment 4 completed NCT01823081
Combined Intravitreal Fasudil and Bevacizumab for Diabetic Macular Edema treatment 3 completed NCT05736081
Short-term Effect of Intravitreal Dexamethasone Implant in Refractory Diabetic Macular Edema treatment 4 completed NCT00446381
Effect of Macugen(Pegaptanib)on Surgical Outcomes and VEGF Levels in Diabetic Patients With PDR (Diabetic Retinopathy or CSDME (Macular Edema) diagnostic Not Available completed NCT03519581
Micropulse for Suppression of Diabetic Macular Edema No drug interventions treatment Not Available completed NCT04469595
A Study of Intravitreal ILUVIEN® Implant as Baseline Therapy in Patients With Early Diabetic Macular Edema (DME) treatment 4 active_not_recruiting NCT02310295
Prospective, Randomized Clinical Trial Comparing Macular Photocoagulation With or Without Intravitreal Bevacizumab or Triamcinolone for the Treatment of Diabetic Macular Edema treatment Not Available completed NCT01876914
Pilot Study of OCT Versus Fluorescein Angiography in DME No drug interventions Not Available Not Available completed NCT01135914
Safety, Efficacy and Cost-efficacy of Ranibizumab (Monotherapy or Combination With Laser) in the Treatment of Diabetic Macular Edema (DME) treatment 3 completed NCT01523314
Topical Dexamethasone - Cyclodextrin Microparticle Eye Drops for Diabetic Macular Edema treatment 2 / 3 unknown_status NCT02826655
Adaptive Optics for Ophthalmic Technologies No drug interventions device_feasibility Not Available terminated NCT02699450
A Study of Faricimab (RO6867461) in Participants With Center-Involving Diabetic Macular Edema treatment 2 completed NCT06498050
Brolucizumab Efficacy and Safety Single-Arm Descriptive Trial in Patients With Persistent Diabetic Macular Edema treatment 4 recruiting NCT03458923
Intravitreal Diclofenac Versus Intravitreal Ranibizumab for the Treatment of Diabetic Macular Edema. treatment 4 unknown_status NCT03666923
A Study to Evaluate the Safety of THR-687 in Subjects With Diabetic Macular Edema (DME) No drug interventions treatment 1 completed NCT02368756
Long-Term Efficacy and Safety of Intravitreal Aflibercept Injections for the Treatment of Diabetic Macular Edema in Subjects Who Completed the Three Year VISTA-DME Trial (The Endurance 2 Trial) treatment 4 active_not_recruiting