Advanced Soft Tissue Sarcoma (DBCOND0060596)

Identifiers

Synonyms

Advanced Soft Tissue Sarcoma (STS) / Advanced Soft-tissue Sarcoma

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Dacarbazine	An antineoplastic agent used to treat malignant melanoma and Hodgkin's disease.	DNA polymerase alpha subunit Btarget Cytochrome P450 1A1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2E1enzyme 6-phosphogluconate dehydrogenase, decarboxylatingtarget DNAtarget
Paclitaxel	A taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer.	Apoptosis regulator Bcl-2target Tubulin beta-1 chaintarget Cytochrome P450 2C8enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter Multidrug resistance-associated protein 1transporter ATP-binding cassette sub-family C member 10transporter Aromataseenzyme Cytochrome P450 1B1enzyme Solute carrier organic anion transporter family member 1B3transporter Nuclear receptor subfamily 1 group I member 2target Microtubule-associated protein 4target Microtubule-associated protein 2target Microtubule-associated protein tautarget ATP-binding cassette sub-family C member 2transporter
Pazopanib	An antineoplastic agent used in the treatment of advanced renal cell cancer and advanced soft tissue sarcoma in patients with prior chemotherapy.	Vascular endothelial growth factor receptor 1target Vascular endothelial growth factor receptor 2target Vascular endothelial growth factor receptor 3target Platelet-derived growth factor receptor alphatarget Platelet-derived growth factor receptor betatarget Mast/stem cell growth factor receptor Kittarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 1A2enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter UDP-glucuronosyltransferase 1A1transporter Fibroblast growth factor receptor 3target Tyrosine-protein kinase ITK/TSKtarget Fibroblast growth factor 1target SH2B adapter protein 3target
Vinblastine	A vinca alkaloid used to treat breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non-Hodgkins lymphoma, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.	Tubulin beta chaintarget Transcription factor Juntarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Multidrug resistance-associated protein 1transporter ATP-binding cassette sub-family C member 2transporter ATP-binding cassette sub-family C member 6transporter Bile salt export pumptransporter Tubulin alpha-1A chaintarget Tubulin delta chaintarget Tubulin epsilon chaintarget Tubulin gamma-1 chaintarget Cytochrome P450 2D6enzyme Solute carrier organic anion transporter family member 1B1transporter Tubulin beta-2A chaintarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06498648	Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma	Abemaciclib Docetaxel Gemcitabine	treatment	1 / 2	not_yet_recruiting
NCT04204941	Tazemetostat in Combination With Doxorubicin as Frontline Therapy for Advanced Epithelioid Sarcoma	Doxorubicin Tazemetostat	treatment	3	recruiting
NCT05333458	Testing Atezolizumab With or Without Selinexor in Patients >= 18 Years Old With Alveolar Soft Part Sarcoma, the Axiom Study	Atezolizumab Escitalopram Selinexor	treatment	2	recruiting
NCT05182164	Combination of Pembrolizumab and Cabozantinib in Patients With Advanced Sarcomas	Cabozantinib Pembrolizumab	treatment	2	recruiting
NCT04874311	Bintrafusp Alfa and Doxorubicin Hydrochloride in Treating Patients With Advanced Sarcoma	Bintrafusp alfa Doxorubicin	treatment	2	recruiting
NCT06370871	Brightline-3: A Study to Find Out Whether Brigimadlin in Combination With Ezabenlimab Helps People With Advanced Soft Tissue Sarcoma	Brigimadlin Docetaxel Ezabenlimab Gemcitabine	treatment	3	withdrawn
NCT06367075	A Trial of Cadonilimab With Adriamycin in Patients With Advanced Soft Tissue Sarcoma	Cadonilimab Doxorubicin	treatment	2	not_yet_recruiting
NCT03660930	Nab-Sirolimus and Pazopanib Hydrochloride in Treating Patients With Advanced Nonadipocytic Soft Tissue Sarcomas	Albumin human Pazopanib Sirolimus	treatment	1 / 2	active_not_recruiting
NCT05809830	Phase I/II of LB-100 Plus Doxorubicin vs. Doxorubicin Alone in First Line of Advanced Soft Tissue Sarcomas	Doxorubicin LB-100	treatment	1 / 2	recruiting
NCT05099666	Lurbinectedin + Doxorubicin In Leiomyosarcoma	Doxorubicin Lurbinectedin	treatment	1 / 2	recruiting
NCT03698227	OlaReDo - Olaratumab and Rechallenge With Doxorubicin in Soft Tissue Sarcoma Patients	Dexrazoxane Doxorubicin Olaratumab	treatment	2	terminated
NCT06062927	Geno-radiomics Based Model for Evaluation of Immunotherapy and Targeted Therapy for Advanced Soft Tissue Sarcoma	No drug interventions	Not Available	Not Available	recruiting
NCT05146440	Multicohort Trial of Different Schemes of PM14 in Monotherapy and in Combination With Radiotherapy in Soft Tissue Sarcomas and Other Solid Tumor	Olive oil	treatment	1 / 2	recruiting
NCT03009201	Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery	Doxorubicin Ribociclib	treatment	1	completed
NCT03670069	Itacitinib in Treating Patients With Refractory Metastatic/Advanced Sarcomas	Itacitinib	treatment	1	terminated
NCT05180695	HDM201 and Pazopanib in Patients With P53 Wild-type Advanced/Metastatic Soft Tissue Sarcomas	Pazopanib Siremadlin	treatment	1 / 2	recruiting
NCT04780464	A 3 Arm Randomized Study on Health-related QoL of Elderly Patients With Advanced Soft Tissue Sarcoma	Cyclophosphamide Doxorubicin Prednisolone Prednisone	treatment	3	terminated
NCT03138161	SAINT:Trabectedin, Ipilimumab and Nivolumab as First Line Treatment for Advanced Soft Tissue Sarcoma	Ipilimumab Nivolumab Trabectedin	treatment	1 / 2	recruiting
NCT05620693	Study of NY-ESO-1 TCR-T in Advanced Soft Tissue Sarcoma	Cancer/testis antigen 1	treatment	Not Available	recruiting
NCT05876715	LINNOVATE: Lurbinectedin, Ipilimumab and Nivolumab for Soft Tissue Sarcoma	Ipilimumab Lurbinectedin Nivolumab	treatment	1 / 2	recruiting
NCT04757337	Comparison of Oral Cyclophosphamide vs Doxorubicin in ≥65 Years Old Advanced or Metastatic Soft Tissue Sarcoma Patients	Cyclophosphamide Doxorubicin	treatment	3	recruiting
NCT01684449	Gemcitabine Plus Rapamycin Versus Gemcitabine to Treat Advanced Soft Tissue Sarcoma	Gemcitabine Sirolimus	treatment	1 / 2	completed
NCT05043649	Camsirubicin + Pegfilgrastim to Determine MTD in ASTS	Camsirubicin Pegfilgrastim	treatment	1	terminated
NCT04705818	Combining Epigenetic And Immune Therapy to Beat Cancer.	Durvalumab Tazemetostat	treatment	2	recruiting
NCT01975519	A Phase 1B Dose-escalation and Phase 2a Study of Carotuximab (TRC105) in Combination With Pazopanib in Patients With Advanced Soft Tissue Sarcoma	Carotuximab Pazopanib	treatment	1 / 2	completed
NCT04028063	Doxorubicin Plus Dual Checkpoint Blockade for Soft Tissue Sarcomas	Balstilimab Botensilimab Doxorubicin Zalifrelimab	treatment	2	recruiting
NCT02618122	A Multicenter, Prospective, oBservational Study to assEss the Clinical activitY and Impact on symptOm Burden and patieNts' HRQoL of Treatment With trabecteDin in aSTS in a Real World Setting in Greece	No drug interventions	Not Available	Not Available	completed
NCT05154630	Study on Tolerability and Pharmacokinetics of TQB2858 Injection in Subjects With Advanced Malignant Tumors	No drug interventions	treatment	1 / 2	terminated
NCT03022448	Geriatric Assessmen of Elderly "Unsuited" Patients Receiving Trabectedin in First Line Treatment For Advanced Soft Tissue Sarcomas (STS)	No drug interventions	Not Available	Not Available	completed
NCT03838744	Randomized Trial in Advanced, Metastatic or Unresectable Soft Tissue Sarcoma After Failure of Standard Treatments.	Olaparib Trabectedin	treatment	2	active_not_recruiting