Relapsed Chronic Lymphocytic Leukemia (DBCOND0060745)

Identifiers

Synonyms

Chronic Lymphoid Leukemia in Relapse / CLL, Relapsed / Relapsed CLL / Chronic, relapsed Lymphocytic Leukemia / Relapse Chronic lymphocytic leukemia / Chronic lymphoid leukemia in relapse (disorder) / Chronic lymphocytic leukemia recurrent / Chronic lymphocytic leukaemia recurrent

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Duvelisib	An inhibitor of phosphatidylinositol 3-kinase delta and gamma used to treat relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.	Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
Idelalisib	An antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL).	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget Broad substrate specificity ATP-binding cassette transporter ABCG2transporter ATP-dependent translocase ABCB1transporter Aldehyde oxidaseenzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2B6enzyme Cytochrome P450 3A4enzyme Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Cytochrome P450 3A5enzyme Cytochrome P450 3A43enzyme Cytochrome P450 3A7enzyme UDP-glucuronosyltransferase 1A4enzyme
Lisocabtagene maraleucel	A CAR T-cell therapy for treatment resistant or more severe B-cell lymphomas.	B-lymphocyte antigen CD19target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05069051	Belimumab in Patients With Chronic Lymphocytic Leukemia	Belimumab	treatment	2	recruiting
NCT04030195	Dose-escalation Study of Safety of PBCAR20A in Subjects With r/r NHL or r/r CLL/SLL	Cyclophosphamide Fludarabine	treatment	1 / 2	completed
NCT05360238	Study to Assess Safety, Tolerability and Efficacy of MB-106 in Patients With Relapsed or Refractory B-Cell NHL or CLL	No drug interventions	treatment	1 / 2	terminated
NCT04512105	Pitavastatin in Combination With Venetoclax for Chronic Lymphocytic Leukemia or Acute Myeloid Leukemia	Pitavastatin Venetoclax	treatment	1	active_not_recruiting
NCT05621148	REfractorinesS to Ibrutinib BTKi and Systemic Targeted Therapy	No drug interventions	Not Available	Not Available	completed
NCT03091933	Antiminor Histocompatibility Complex (MiHA) T Cells for Patients With Relapsed Hematologic Malignancies Following Matched HSCT (Guided Lymphocyte Immunopeptide Derived Expansion)	No drug interventions	treatment	1 / 2	unknown_status
NCT03774654	CD19.CAR Allogeneic NKT for Patients With Relapsed or Refractory B-Cell Malignancies (ANCHOR)	No drug interventions	treatment	1	recruiting
NCT03639324	Rituximab, Idelalisib, and Venetoclax in Relapsed/Refractory CLL/SLL	No drug interventions	treatment	1	withdrawn
NCT04624633	Acalabrutinib, Umbralisib, and Ublituximab (AU2) In Relapsed and Untreated CLL	Acalabrutinib Ublituximab Umbralisib	treatment	2	active_not_recruiting
NCT05828589	A Study of BGB-21447, a Bcl-2 Inhibitor, in Mature B-Cell Malignancies	No drug interventions	treatment	1	recruiting
NCT04191187	Reduced Intensity Flu/Mel/TBI Conditioning for HAPLO HCT Patients With Hematologic Malignancies	Fludarabine Melphalan	treatment	2	active_not_recruiting
NCT05246345	Venetoclax Resistance Landscape in Chronic Lymphocytic Leukemia	No drug interventions	Not Available	Not Available	recruiting
NCT05805605	Allo HSCT Using RIC and PTCy for Hematological Diseases	Allopurinol Cyclophosphamide Fludarabine Mycophenolate mofetil Sirolimus	treatment	2	recruiting
NCT02181478	Intra-Osseous Co-Transplant of UCB and hMSC	Cyclophosphamide Cyclosporine Fludarabine Mycophenolate mofetil	treatment	0	completed
NCT04305444	Study of a Triple Combination Therapy, DTRM-555, in Patients With R/R CLL or R/R Non-Hodgkin's Lymphomas	Everolimus Pomalidomide	treatment	2	active_not_recruiting
NCT01750567	A Pilot Study of Metformin Therapy in Patients With Relapsed Chronic Lymphocytic Leukemia (CLL) and Untreated CLL	Metformin	treatment	2	active_not_recruiting
NCT02722668	UCB Transplant for Hematological Diseases Using a Non Myeloablative Prep	Cyclophosphamide Fludarabine Mycophenolate mofetil Sirolimus	treatment	2	active_not_recruiting
NCT05479994	Study of BGB-11417 in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma	Sonrotoclax	treatment	2	recruiting