Advanced Hormone Dependent Prostate Cancer (DBCOND0064061)

Identifiers

Synonyms

Advanced Hormone-dependent prostate cancer

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Degarelix	A GnRH receptor antagonist used in the management of advanced prostate cancer.	Gonadotropin-releasing hormone receptortarget
Estradiol valerate	An estradiol prodrug used to treat some effects of menopause, hypoestrogenism, androgen dependant carcinoma of the prostate, and in combination products for endometriosis and contraception.	Estrogen receptortarget Nuclear receptor subfamily 1 group I member 2target Sex hormone-binding globulincarrier Estrogen receptor betatarget Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 1A1enzyme Albumincarrier Fatty acid-binding protein, intestinalcarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Solute carrier family 22 member 3transporter Solute carrier organic anion transporter family member 2B1transporter Solute carrier organic anion transporter family member 1A2transporter ATP-binding cassette sub-family C member 10transporter Solute carrier family 22 member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 1C1transporter Solute carrier organic anion transporter family member 4A1transporter Neuronal acetylcholine receptor subunit alpha-4target Nuclear receptor coactivator 2target G-protein coupled estrogen receptor 1target ATP synthase subunit atarget Beclin-1target 17-beta-hydroxysteroid dehydrogenase type 2target Estrogen-related receptor gammatarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01861236	Effectiveness and Safety of Firmagon® in Androgen Ablative Therapy of Advanced Hormone-dependent Prostate Carcinoma in Argentina	Degarelix	Not Available	Not Available	completed