Familial Mediterranean Fever (FMF ) (DBCOND0067538)

Identifiers

Synonyms

Familial Mediterranean Syndrome / Familial Mediterranean Fever (FMF) / Familial Mediterranean Fever / Periodic fever syndromes / Familial Mediterranean fever (disorder) / Familial recurrent polyserositis

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Canakinumab	An interleukin-1β blocker used to treat Periodic Fever Syndromes such as Cryopyrin-Associated Periodic Syndromes (CAPS) and Familial Mediterranean Fever (FMF), and also to treat active Systemic Juvenile Idiopathic Arthritis (SJIA).	Interleukin-1 betatarget
Colchicine	An alkaloid used to treat gout and Familial Mediterranean Fever as well as prevent major cardiovascular events.	Tubulin beta chaintarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2E1enzyme Albumincarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00035334	Study of the Safety and Efficacy of NC-503 in Secondary (AA) Amyloidosis	Eprodisate	treatment	2 / 3	completed
NCT00001373	Familial Mediterranean Fever and Related Disorders: Genetics and Disease Characteristics	No drug interventions	Not Available	Not Available	recruiting
NCT03563300	Gluten-related Disorders in Familial Mediterranean Fever Patients	No drug interventions	diagnostic	Not Available	completed
NCT05596643	Investigation of Autonomic Dysfunction in Patients With Familial Mediterranean Fever	No drug interventions	Not Available	Not Available	recruiting
NCT05488561	Clinical and Molecular Evaluation of Childern With Familial Meditterranean Fever and Their Siblings	No drug interventions	screening	Not Available	unknown_status
NCT04724993	Effects of Online Aerobic Exercise Training and Physical Activity Counseling in Juvenile Familial Mediterranean Fever	No drug interventions	treatment	Not Available	unknown_status
NCT00582907	Rilonacept for Treatment of Familial Mediterranean Fever (FMF)	Rilonacept	treatment	2	completed
NCT03446209	Tocilizumab for the Treatment of Familial Mediterranean Fever	Tocilizumab	treatment	2	completed
NCT06257342	Physical Abilities of Teenagers With Familial Mediterranean Fever	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT01075906	Pharmacokinetics Study of Colchicine in Familial Mediterranean Fever (FMF) Patients	Colchicine	basic_science	1	completed
NCT05092776	Efficacy and Safety of RPH-104 for Resolution and Prevention of Recurring Attacks in Adult Subjects With Familial Mediterranean Fever With Resistance to or Intolerance of Colchicine	Goflikicept	treatment	2	recruiting
NCT05448391	A Study to Evaluate RIST4721 in Familial Mediterranean Fever (FMF)	No drug interventions	treatment	2	withdrawn
NCT05190991	Safety and Efficacy of RPH-104 Used to Prevent Recurrent Fever Attacks in Adult Patients With Colchicine Resistant or Colchicine Intolerant Familial Mediterranean Fever	Goflikicept	treatment	2	recruiting
NCT02175589	Controlled Ceasing of Colchicine Therapy in Familial Mediterranean Fever (FMF) Patients With Single MEFV (Mediterranean Fever) Gene Mutation	No drug interventions	treatment	2	unknown_status
NCT00323440	Inflammatory Proteins in Familial Mediterranean Fever During Attack and Remission	No drug interventions	Not Available	Not Available	withdrawn
NCT06034795	Evaluation of Bone Metabolism in Children and Adolescents With Familial Mediterranean Fever	No drug interventions	Not Available	Not Available	recruiting
NCT01059279	Heat Intolerance in the Group of FMF Patients	No drug interventions	Not Available	Not Available	terminated
NCT02602028	The Comparison of the Efficacy of Once and Twice Daily Colchicine Dosage in Pediatric Patients With FMF	Colchicine	treatment	4	completed
NCT04478409	Characterization of a Functional Test for Mediterranean Family Fever Screening - 2	No drug interventions	Not Available	Not Available	recruiting
NCT01705756	Kineret (Anakinra), in Adult Patients With Colchicine-Resistant Familial Mediterranean Fever	Anakinra	treatment	3	completed
NCT03747315	A Diagnostic Test for Familial Mediterranean Fever	No drug interventions	Not Available	Not Available	completed
NCT00094900	Interleukin-1 Trap to Treat Autoinflammatory Diseases	Rilonacept	treatment	2	completed
NCT04729218	The Movement Imagery Ability in Patients With Familial Mediterranean Fever	No drug interventions	Not Available	Not Available	completed
NCT06033339	Assessment of microRNAs Role in Familial Mediterranean Fever FMF Pathophysiology	No drug interventions	other	Not Available	not_yet_recruiting
NCT05177120	Central Sensitization in Familial Mediterranean Fever (FMF)	No drug interventions	Not Available	Not Available	completed
NCT00658060	Magnetic Resonance (MR) Spectroscopy In Familial Mediterranean Fever (FMF) Patients	No drug interventions	Not Available	Not Available	unknown_status
NCT06338891	Can Gluten/Wheat or Other Foods be Responsible for FMF Attacks	No drug interventions	Not Available	Not Available	recruiting
NCT01088880	Efficacy and Safety of Canakinumab in Patients With Colchicine Resistant Familial Mediterranean Fever	Canakinumab	treatment	2	completed
NCT02021084	The Effect of Probiotics on Response to Therapy and on Adverse Effect in Patients Treated With Colchicine for Familial Mediterranean Fever.	No drug interventions	treatment	Not Available	withdrawn
NCT06583304	Hematological Indices in Pediatric Diagnosed with Familial Mediterranean Fever	No drug interventions	Not Available	Not Available	not_yet_recruiting