Depressive Disorder, Treatment Resistant

Depressive Disorder, Treatment Resistant is the indication for 3 drugs in DrugBank. It is covered by 3 curated, structured indications.

Also known as: Depressive Disorder, Treatment-Resistant · Treatment Resistant Depression · Therapy-Resistant Depression · Treatment Resistant Depression (TRD) · Treatment-Resistant Depression
Classified under: Mental Disorders
Psychosocial, Behavioral, and Demographic Factors
Indicated drugs: Esketamine
Fluoxetine
Olanzapine

Resolves to

Vocabularies

MeSHM0556716ICD-10F33.9SNOMED CT1153570009MedDRA10012377UMLSC0011570

What you can answer from here — as of October 31, 2026

3Indicated drugsWith each drug's targets and mechanism

Listed above

3Structured indicationsPopulation, line of therapy, route and combination as fields, not prose

224Clinical trialsPhase, status and sponsor resolved per trial

Which approved drugs for Depressive Disorder, Treatment Resistant share a target, and which companies have late-stage candidates against it?

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