Atherosclerotic Cardiovascular Diseases (DBCOND0078488)

Identifiers

Synonyms
Atherosclerotic Cardiovascular Disease / Atheromatosis / Atherosclerotic heart disease of native coronary artery / Atherosclerosis / Atherosclerosis (morphologic abnormality) / Arteriosclerotic vascular disease (disorder) / Arteriosclerosis / Arteriosclerosis (morphologic abnormality) / Vascular sclerosis (morphologic abnormality)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Acetylsalicylic acid
A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.
Bempedoic acid
A drug used in conjunction with lifestyle modification and/or other agents for the treatment of refractory hypercholesterolemia.
Inclisiran
A PCSK9-targeting short interfering RNA (siRNA) that lowers plasma LDL-cholesterol levels.
Rosuvastatin
An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05485961
Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysissupportive_care2 / 3recruiting
NCT05726838
The Belgian REAL (BE.REAL) RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT06675175
A Phase 1b Study to Assess the Safety, Tolerability, and Pharmacodynamics of AZD4144 in Participants With Established Atherosclerotic Cardiovascular and Chronic Kidney Disease.No drug interventionstreatment1not_yet_recruiting
NCT06249165
VictORION-INCLUSION: Evaluating Inclisiran for Cholesterol Managment in Heart Diseasetreatment4not_yet_recruiting
NCT04807400
Study in Primary Care Evaluating Inclisiran Delivery Implementation + Enhanced Supporthealth_services_research3completed
NCT05142722
Randomized Study to Evaluate the Effect of Obicetrapib on Top of Maximum Tolerated Lipid-Modifying Therapiestreatment3completed
NCT05030428
Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Diseasetreatment3active_not_recruiting
NCT04929249
A Randomized Study to Evaluate the Effect of an "Inclisiran First" Implementation Strategy Compared to Usual Care in Patients With Atherosclerotic Cardiovascular Disease and Elevated LDL-C Despite Receiving Maximally Tolerated Statin Therapy (VICTORION-INITIATE)treatment3completed
NCT06424860
Fish Oil, Metformin and Heart Health in PCOStreatment1not_yet_recruiting
NCT01330602
Intima-Medial Thickness Guidance of Primary Prevention in Relatives of Patients With Early onSet AtherosclerosisNo drug interventionsscreeningNot Availableunknown_status
NCT01663402
ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumabprevention3completed
NCT05792787
Association Between Apical Periodontitis and Atherosclerotic Cardiovascular DiseasesNo drug interventionsNot AvailableNot Availablecompleted
NCT05294653
Atherosclerotic Cardiovascular Risk in Childhood and Teen-age Onset DiabetesNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04789278
Incidental Coronary Calcification Quality Improvement ProjectNo drug interventionsotherNot Availableunknown_status
NCT03096288
Impact of Evolocumab on the Effects of Clopidogrel in Patients With High On-Treatment Platelet Reactivitytreatment4completed
NCT05202509
Cardiovascular Outcome Study to Evaluate the Effect of Obicetrapib in Patients With Cardiovascular Diseasetreatment3active_not_recruiting
NCT03403556
High-intensity Rosuvastatin vs. Moderate-intensity Rosuvastatin/Ezetimibe in High Atherosclerotic Cardiovascular Disease Risk Patients With Type 2 DiabetesNo drug interventionstreatment4unknown_status
NCT06507852
A Real-world Study of Inclisiran Adherence, Treatment Patterns, Patient Characteristics, and Effectiveness in ASCVD Patients With Hypercholesterolemia, ASCVD-risk Equivalent Patients With Hypercholesterolemia and Familial HypercholesterolemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT04462159
The Young Heart StudyNo drug interventionsotherNot Availableactive_not_recruiting
NCT01572259
Assessment of the Role of the Growth Hormone (GH) Onthe Intestinal Triglyceride-rich-lipoproteins (TRL) MetabolismNot Available3unknown_status
NCT03067441
Assessment of the Long-Term Safety and Efficacy of Bempedoic Acid (CLEAR Harmony OLE)treatment3completed
NCT03705234
A Randomized Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Cardiovascular Diseaseprevention3active_not_recruiting
NCT04924686
Changes of Muramyl Dipeptide in Intestinal and Extra-intestinal DiseasesNo drug interventionsNot AvailableNot Availableunknown_status
NCT01353066
Gastric Bypass Versus Best Medical Treatment on Progression of Carotid-intima Media Thickness in Type 2 Diabetes Mellitus (T2DM)No drug interventionstreatment2 / 3unknown_status
NCT05278182
A Study for Exploring the Efficacy of Naoxintong Capsules in the Treatment of Coronary Atherosclerotic Plaque on the Basis of Optimal Medical Therapy (Aspirin,Statins,Clopidogrel, Etc.): Stage OneNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03505073
Association Between Dietary Habits and Risk Factors for Atherosclerotic Cardiovascular Diseases in Assiut GovernorateNo drug interventionsNot AvailableNot Availableunknown_status
NCT03749473
Evaluation of the Novel Use of Gamification With Alternative Goal-setting ExperiencesNo drug interventionshealth_services_researchNot Availablecompleted
NCT06112327
Long-term Follow-up of Participants Dosed With an Investigational Gene Editing Therapy for Cardiovascular DiseaseNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT06541691
Coated or Chewable Aspirin and a Hybrid Strategy to Mitigate Adverse Effects of Air Pollution in Stable Atherosclerotic DiseasepreventionNot Availablerecruiting
NCT05271591
Generalizability of REDUCE-IT Results to People of South Asian Descent With Atherosclerotic Cardiovascular Disease in Canada (REDUCE-IT Canada SA)No drug interventionsNot AvailableNot Availablecompleted
NCT05378529
A Cross-sectional Study of Lipoprotein(a) Levels in Patients With Documented History of Atherosclerotic Cardiovascular Disease (ASCVD)No drug interventionsbasic_scienceNot Availablecompleted
NCT05639244
Time Restricted Eating and Innate ImmunityNo drug interventionsotherNot Availablecompleted
NCT02576067
Cardiovascular Inflammation Reduction Trial - Inflammation Imaging Studytreatment3completed
NCT05629767
Tracking of Lipid Lowering Therapy in JordanNo drug interventionsNot AvailableNot Availableterminated
NCT06494501
The Prevent Coronary Artery Disease Trialprevention3recruiting
NCT05705804
Effects of Pitavastatin or Combination of Pitavastatin and Ezetimibe on Glucose Metabolism Compared to AtoRvastatin in atheroscLerotic Cardiovascular Disease Patients With Metabolic Syndrome: The EZ-PEARL Randomized TrialtreatmentNot Availablerecruiting
NCT06443814
Trial of Meditation for Cardiometabolic Disease in Older Black WomenNo drug interventionsprevention2completed
NCT05581303
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trialtreatment3active_not_recruiting
NCT05355402
A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Adults With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), and/or With Severe Hypertriglyceridemiatreatment2completed
NCT03911284
The Learning RegistryNo drug interventionsNot AvailableNot Availablecompleted
NCT01252953
REVEAL: Randomized EValuation of the Effects of Anacetrapib Through Lipid-modificationprevention3active_not_recruiting
NCT03060577
An Extension Trial of Inclisiran in Participants With Cardiovascular Disease and High Cholesteroltreatment2completed
NCT04828447
Recipe for Heart HealthNo drug interventionsotherNot Availablecompleted
NCT05974345
In Silico Study Assessing the Impact of Inclisiran on Major Adverse Cardiovascular Events in Patients With Established Cardiovascular DiseaseNot AvailableNot Availablecompleted
NCT05976893
Study on the Composite Endpoint Event of PCSK9 Inhibitor in Patients With Very High Risk of ASCVD and Cancertreatment4not_yet_recruiting
NCT02388971
Proof of Mechanism Study of MLN1202 on Atherosclerotic Inflammation in Participants With Stable Atherosclerotic Cardiovascular Diseasetreatment2withdrawn
NCT02931188
The Effect of Anacetrapib on Vascular Function and Arterial StiffnessNot AvailableNot Availablecompleted
NCT06048588
YN001 in Healthy Subjects and Patients With Coronary Atherosclerosistreatment1 / 2recruiting
NCT05659888
Real Life Lipid Management in Hospitals Not Participating in PENELOPE Trial - Control Population for PENELOPENo drug interventionsNot AvailableNot Availablecompleted
NCT05720156
Immunomodulatory Effects of PCSK9 InhibitionNo drug interventionsNot AvailableNot Availablerecruiting
NCT00185185
Olmesartan Medoxomil in Atherosclerosistreatment3completed
NCT02988115
Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) in Patients With Hyperlipidemia and Statin Intoleranttreatment3completed
NCT05724615
Default Bulk Ordering and Text Messaging to Enhance Outreach for Lipid Screening (Missing Lipids)No drug interventionsscreeningNot Availablecompleted
NCT04215237
How Atorvastatin Affects the Gut Flora and Metabolomics?basic_scienceNot Availableunknown_status
NCT05765370
LDL Cholesterol TARGETs in OLDer Patients (Age≥75 Years) With ASCVD (TARGET OLD)No drug interventionstreatmentNot Availablerecruiting
NCT03826836
Mind Our Heart StudyNo drug interventionssupportive_careNot Availablenot_yet_recruiting
NCT05977413
NOTIFY (New Observations Taking Information From Yesterday)No drug interventionspreventionNot Availablenot_yet_recruiting
NCT05639218
Impact of Optimal Pharmacotherapy on Lipid Profile and Qualitative Features of Atherosclerotic PlaquesNot AvailableNot Availableactive_not_recruiting
NCT02991118
Evaluation of Long-Term Efficacy of Bempedoic Acid (ETC-1002) in Patients With Hyperlipidemia at High Cardiovascular Risktreatment3completed
NCT05129241
Non-interventional Study on the Monthly Administration of 300 mg AliRocumab (PRALUENT®) With the 2 ml SYDNEY Auto-injectorNo drug interventionsNot AvailableNot Availablecompleted
NCT03911141
Behavioral Economic Approaches to Increase Physical Activity Among Patients With Elevated Risk for Cardiovascular DiseaseNo drug interventionshealth_services_researchNot Availablecompleted
NCT03228017
Subclinical Cardiovascular Disease in Psoriatic Diseasetreatment4completed
NCT00856817
Heme Oxygenase (HO) Activity and Adenosine Induced Vasodilationprevention4terminated
NCT02697916
Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-termpreventionNot Availablecompleted
NCT05409716
Compressive Elastic Dressing Versus TR BandNo drug interventionstreatmentNot Availablecompleted
NCT04271735
Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in PsoriasisNo drug interventionsbasic_scienceNot Availablecompleted
NCT04338165
Impact of PCSK9 Inhibitors on Coronary Microvascular Dysfunction in Patients With Atherosclerotic Cardiovascular Disease Proved by Myocardial Ischemia and Needing Coronarographytreatment2unknown_status
NCT04992065
A Research Study Looking at How NNC0385-0434 Tablets Work to Lower Blood Cholesterol in People With Heart Disease or a High Risk of Heart Diseasetreatment2completed
NCT03626831
Effect of Evolocumab on Vascular Functiontreatment4completed
NCT04626973
Effects of Ezetimibe Combination Therapy for Patients With Atherosclerotic Cardiovascular Disease; Randomized Comparison of LDL-cholesterol Targeting <70 Versus <55mg/dL; Ez-PAVE TrialtreatmentNot Availablerecruiting
NCT02597127
Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C)treatment2completed
NCT06571162
A Pragmatic INitiative for LDL-C Management by a CLinical Pharmacist-Led Team Among Atherosclerotic CardiovascUlar DisEase PatientsNo drug interventionshealth_services_researchNot Availablenot_yet_recruiting
NCT04271280
Treatment of High and Very High riSk Dyslipidemic pAtients for the PreveNTion of CardiOvasculaR EventsNo drug interventionsNot AvailableNot Availablecompleted
NCT05398029
A Study of VERVE-101 in Patients With Familial Hypercholesterolemia and Cardiovascular DiseaseNo drug interventionstreatment1active_not_recruiting
NCT05761444
Effectiveness and Safety Study of Early add-on of Ezetimibe With Atorvastatin in Very High-risk Patientstreatment4active_not_recruiting
NCT01433744
Short-term Changes on C-Reactive Protein (CRP) Levels After Non-surgical Periodontal TreatmentNo drug interventionstreatmentNot Availablecompleted
NCT05003440
A Research Study Looking at How the Medicine NNC0385-0434 Works in the Body of Healthy Japanese MenNo drug interventionstreatment1completed
NCT01666704
Proof of Concept Study of BMS-823778 to Assess the Effects on AtherosclerosisNo drug interventionstreatment2withdrawn
NCT03597412
Rosuvastatin/Ezetimibe Versus Rosuvastatin in ASCVD Patients With Type 2 DMNo drug interventionstreatment4completed
NCT02666664
Evaluation of Long-Term Safety and Tolerability of ETC-1002 in High-Risk Patients With Hyperlipidemia and High CV Risk (CLEAR Harmony)treatment3completed
NCT06471803
Multi-omics Merge for Ensemble Subtyping for Atherosclerotic Cardiovascular DiseaseNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT01679288
Screening for Abdominal Aortic Aneurysm and Abdominal Aortic Atherosclerosis by Hand-Held UltrasonographyNo drug interventionsscreeningNot Availablecompleted
NCT06242171
Prognostic Indices of Atheromatosis Severity and Coronary Artery Bypass Surgery Outcomes for Patients With Coronary Artery DiseaseNo drug interventionsNot AvailableNot Availableactive_not_recruiting