Inflammatory Breast Cancer (IBC) (DBCOND0084733)

Identifiers

Synonyms

Inflammatory carcinoma of the breast / Inflammatory Breast Cancer / Inflammatory carcinoma of breast (disorder) / Inflammatory Breast Neoplasms / Breast carcinoma inflammatory

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Hyaluronidase (human recombinant)	An enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents.	Hyaluronic acidtarget Transforming growth factor beta-1 proproteintarget
Pertuzumab	An antineoplastic agent used in the treatment of HER2-positive metastatic breast cancer in combination with other antineoplastic agents.	Receptor tyrosine-protein kinase erbB-2target
Trastuzumab	A monoclonal anti-human epidermal growth factor receptor 2 protein antibody used to treat HER2-positive breast, gastroesophageal, and gastric cancers.	Receptor tyrosine-protein kinase erbB-2target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02876302	Study Of Ruxolitinib (INCB018424) With Preoperative Chemotherapy For Triple Negative Inflammatory Breast Cancer	Cyclophosphamide Doxorubicin Paclitaxel Ruxolitinib	treatment	2	active_not_recruiting
NCT05415215	A Study to Evaluate Patient Preference for Home Administration of Fixed-Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Administration in Participants With Early or Locally Advanced/Inflammatory HER2-Positive Breast Cancer	Hyaluronidase (human recombinant) Pertuzumab Trastuzumab Trastuzumab emtansine	treatment	3	active_not_recruiting
NCT05383196	Onvansertib + Paclitaxel in TNBC	Onvansertib Paclitaxel	treatment	1 / 2	recruiting
NCT02682693	Denosumab as an add-on Neoadjuvant Treatment (GeparX)	Carboplatin Cyclophosphamide Denosumab Epirubicin Paclitaxel Pertuzumab Trastuzumab	treatment	2	completed
NCT00344071	Pilot Study of Inflammatory Breast Cancer in Egypt and Tunisia	No drug interventions	Not Available	Not Available	completed
NCT04030507	Screening Magnetic Resonance Imaging of the Brain in Patients With Breast Cancer	No drug interventions	screening	Not Available	recruiting
NCT00986609	MUC1 Vaccine for Triple-negative Breast Cancer	Carboxymethylcellulose Hiltonol Lysine Polyinosinic-polycytidylic acid	other	0	completed
NCT01880385	Efficacy and Safety of Bevacizumab in the Neodjuvant Treatment of Inflammatory Breast Cancer	Bevacizumab Cyclophosphamide Docetaxel Epirubicin Fluorouracil Trastuzumab	treatment	1	unknown_status
NCT06131632	Conserving Surgery in Inflammatory Breast Cancer After Neoadjuvant Chemotherapy	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT02221999	Weekly Paclitaxel and Cisplatin to Treat Hormone Receptor Positive and Triple Negative Breast Cancer Patients	Cisplatin Gonadorelin Letrozole Paclitaxel	treatment	2 / 3	active_not_recruiting
NCT00003199	Combination Chemotherapy and Peripheral Blood Stem Cell Transplant Followed By Aldesleukin and Sargramostim in Treating Patients With Inflammatory Stage IIIB or Metastatic Stage IV Breast Cancer	Aldesleukin Busulfan Melphalan Sargramostim Tamoxifen Thiotepa	treatment	2	completed
NCT01417286	Accelerated Radiation Therapy After Surgery in Treating Patients With Breast Cancer	No drug interventions	treatment	2	completed
NCT01583426	Nanoparticle-based Paclitaxel vs Solvent-based Paclitaxel as Part of Neoadjuvant Chemotherapy for Early Breast Cancer (GeparSepto)	Paclitaxel	treatment	3	completed
NCT04660929	CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors	Pembrolizumab	treatment	1	active_not_recruiting
NCT02125344	A Phase III Trial Comparing Two Dose-dense, Dose-intensified Approaches (ETC and PM(Cb)) for Neoadjuvant Treatment of Patients With High-risk Early Breast Cancer (GeparOcto)	Carboplatin Cyclophosphamide Doxorubicin Epirubicin Ferric carboxymaltose Iron polymaltose Paclitaxel Pertuzumab Trastuzumab	treatment	3	completed
NCT02623972	A Phase 2 Study of Eribulin Followed by AC as Preoperative Therapy for HER2-negative Inflammatory Breast Cancer	Cyclophosphamide Doxorubicin Eribulin	treatment	2	active_not_recruiting
NCT04636710	Refining Local-Regional Therapy for IBC	No drug interventions	diagnostic	Not Available	recruiting
NCT00049114	Tipifarnib, Doxorubicin, and Cyclophosphamide in Treating Women With Locally Advanced Breast Cancer	Cyclophosphamide Doxorubicin Filgrastim Tipifarnib	treatment	2	completed
NCT01938833	Romidepsin and Abraxane in Treating Patients With Metastatic Inflammatory Breast Cancer	Albumin human Paclitaxel Romidepsin	treatment	1 / 2	terminated
NCT03515798	Study of Immunotherapy in Combination With Chemotherapy in HER2-negative Inflammatory Breast Cancer	Cyclophosphamide Epirubicin Paclitaxel Pembrolizumab	treatment	2	active_not_recruiting
NCT02324088	Interest of Maintenance Chemotherapy After Induction Treatment for Inflammatory Breast Cancer	Cyclophosphamide Docetaxel Epirubicin	treatment	3	completed
NCT02879513	Trial of Adjuvant Chemotherapy in Breast Cancer Patients With Pathological Partial Response and Complete Response to Neoadjuvant Chemotherapy	Cisplatin Cyclophosphamide Epirubicin Paclitaxel	treatment	3	unknown_status
NCT02199418	Addition of Cisplatin to Neoadjuvant Therapy for T Locally Advanced Breast Cancer	Cisplatin Paclitaxel	treatment	2	completed
NCT00340158	Establishing an Inflammatory Breast Cancer Registry	No drug interventions	Not Available	Not Available	completed
NCT01525966	Carboplatin and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Before Surgery in Treating Patients With Locally Advanced or Inflammatory Triple Negative Breast Cancer	Albumin human Carboplatin Paclitaxel	treatment	2	active_not_recruiting
NCT00004074	Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu	Carboplatin Edodekin alfa Natural Killer Cell Paclitaxel Trastuzumab	treatment	1	completed
NCT00016276	Combination Chemotherapy, Surgery, and Radiation Therapy With or Without Dexrazoxane and Trastuzumab in Treating Women With Stage III or Stage IV Breast Cancer	Cyclophosphamide Dexrazoxane Doxorubicin Paclitaxel Tamoxifen Trastuzumab	treatment	3	terminated
NCT00891280	Dose-escalation Study of Oral CX-4945	Silmitasertib	treatment	1	unknown_status
NCT01426880	Addition of Carboplatin to Neoadjuvant Therapy for Triple-negative and HER2-positive Early Breast Cancer	Bevacizumab Carboplatin Cisplatin Doxorubicin Lapatinib Paclitaxel	treatment	2 / 3	completed
NCT00513695	Sunitinib Malate, Paclitaxel, Doxorubicin Hydrochloride, and Cyclophosphamide Before Surgery in Treating Patients With Stage IIB-IIIC Breast Cancer	Cyclophosphamide Doxorubicin Filgrastim Paclitaxel Sunitinib	treatment	2	completed