NCT06511544
rTMS to Target Neural Connectivity and Rumination in Treatment-Resistant Depression No drug interventions treatment Not Available recruiting NCT05464264
Auditory MMN EEG in TRD in Response to Ketamine Not Available Not Available recruiting NCT04998773
Efficacy and Biomarkers of Response of TBS in Treatment Resistant Depression No drug interventions treatment Not Available recruiting NCT05007028
Nitrous Oxide for Late-Life Depression - PROTO-BRAIN treatment Not Available recruiting NCT05136027
TReAtment With CombinedExercise in Patients With Resistant Major Depression No drug interventions treatment Not Available recruiting NCT04663321
Efficacy and Safety of MK-1942 When Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression (TRD) (MK-1942-006) No drug interventions treatment 2 terminated NCT05577247
Belief Updating in Treatment Resistant Depression No drug interventions Not Available Not Available recruiting NCT05660642
An Open-Label Study to Evaluate the Safety, Tolerability and Pharmacodynamics of BPL-003 in Patients with Treatment Resistant Depression No drug interventions treatment 2 recruiting NCT05711940
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD treatment 3 recruiting NCT05773755
DBS for TRD with the Medtronic Percept PC No drug interventions basic_science Not Available recruiting NCT06236711
Transcranial Direct Current Stimulation (tDCS) As an Adjunctive Treatment for Treatment Resistant Depression (TRD) No drug interventions treatment Not Available recruiting NCT06423430
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND) No drug interventions treatment Not Available recruiting NCT06378229
Psilocybin for Hospitalized Patients with Treatment-resistant Depression treatment 2 recruiting NCT06462196
Natural History of Depression, Bipolar Disorder and Suicide Risk No drug interventions Not Available Not Available recruiting NCT06404320
Physical Activity Program for TRD No drug interventions treatment Not Available recruiting NCT06013384
Low-Intensity Focused Ultrasound for Treatment-Resistant Depression No drug interventions treatment Not Available recruiting NCT05798143
Translational Biomarkers in Accelerated Neuromodulation for Treatment-resistant Depression No drug interventions treatment Not Available recruiting NCT06278779
Comparative Effectiveness Study of Two Forms of Ketamine for Treatment-resistant Depression treatment 4 recruiting NCT04698603
Clinical Study of GH001 in Depression treatment 1 / 2 completed NCT01868802
Ketamine for Treatment-resistant Depression: A Multicentric Clinical Trial in Mexican Population treatment 2 unknown_status NCT06480500
i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trial treatment 2 recruiting NCT06052137
Open Label - Personalized Therapeutic Neuromodulation for Anhedonic Depression No drug interventions treatment Not Available not_yet_recruiting NCT06095778
rTMS Therapy for Treatment-Resistant Depression With Different Targets Guided by pBFS No drug interventions treatment Not Available recruiting NCT05976022
pBFS Guided rTMS Therapy Over Different Targets for Treatment-Resistant Depression No drug interventions treatment Not Available recruiting NCT05976009
pBFS-Guided rTMS Therapy Over Different Targets for Treatment-Resistant Depression No drug interventions treatment Not Available recruiting NCT05948839
pBFS Guided rTMS Over DMPFC for Treatment-Resistant Depression No drug interventions treatment Not Available recruiting NCT05383313
Psilocybin Versus Ketamine in Treatment-Resistant Depression health_services_research 2 recruiting NCT05355142
An Intervention Study of Anhedonia and Pain Empathy in Depression No drug interventions treatment Not Available unknown_status NCT05113771
A Biomarker-Guided, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With Treatment-Resistant Depression treatment 2 completed NCT04924257
ECT vs. Esketamine treatment 3 withdrawn NCT04608396
Mechanistic Evaluation of Response in TRD (MERIT) No drug interventions treatment 2 completed NCT04504175
Ketamine for Older Adults Pilot treatment 4 completed NCT04451135
CET- REM (Correlating ECT Response to EEG Markers) No drug interventions diagnostic Not Available active_not_recruiting NCT04159285
Psychotherapeutic Augmentation of Brain Stimulation Effects No drug interventions treatment Not Available completed NCT04243798
Establishing a Dose-response Relationship With Accelerated Transcranial Magnetic Stimulation No drug interventions treatment Not Available recruiting NCT04249596
Tianeptine for Treatment Resistant Depression treatment 4 recruiting NCT04226352
Three Dosing Regimens of Dextromethorphan (DXM) Reportedly Used in Major Depressive Disorder other 1 completed NCT04171193
Efficacy of Deep Anaesthesia With Isoflurane as a Fast-response Antidepressant Agent treatment 2 unknown_status NCT04099342
Enhanced Spatial Targeting in ECT Utilizing FEAST No drug interventions treatment Not Available recruiting NCT03986658
Linear Asymmetric rTMS in Adolescent Treatment-Resistant Depression: Tolerability of Treatment Durations Ranging From Ten Days to One Day No drug interventions treatment Not Available unknown_status NCT03833063
Glabellar Botulinum Toxin Injections for the Treatment of Geriatric Depression treatment 1 withdrawn NCT03775200
The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression treatment 2 completed NCT03742557
Evaluation of Schemes of Administration of Intravenous Ketamine in Depression treatment 3 unknown_status NCT03711019
Efficacy of Convulsive Therapies During Continuation No drug interventions treatment Not Available recruiting NCT03684447
Neural and Antidepressant Effects of Propofol treatment 2 / 3 active_not_recruiting NCT03573349
Ketamine Associated ACC GABA and Glutamate Change and Depression Remission: treatment 0 active_not_recruiting NCT03152409
Salicylic Augmentation in Depression treatment 2 terminated NCT03515733
PF-04995274 and Emotional Processing in Treatment Resistant Depression basic_science 1 completed NCT03175887
Investigational TMS Treatment for Depression No drug interventions treatment Not Available withdrawn NCT04856124
Intranasal Esketamine to Maintain the Antidepressant Response to IV Racemic Ketamine Not Available Not Available completed NCT04841798
MAO-B Occupancy in Depressed Patients No drug interventions other Not Available completed NCT04695405
Pharmacogenetics Associated With IV Ketamine No drug interventions Not Available Not Available completed NCT05595356
Home-based Transcranial Direct Current Stimulation for Treatment Resistant Depression No drug interventions treatment Not Available recruiting NCT05615948
Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression treatment 4 completed NCT04433858
An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD) treatment 2 active_not_recruiting NCT04433845
The Safety and Efficacy of Psilocybin in Participants With Type 2 Bipolar Disorder (BP-II) Depression. treatment 2 active_not_recruiting NCT04189939
Computational Psychiatric Approach to Depression No drug interventions Not Available Not Available completed NCT03360942
Long Term Follow-up of Deep Brain Stimulation for Treatment-Resistant Depression No drug interventions Not Available Not Available active_not_recruiting NCT03288675
Stepped Care aiTBS 2 Depression Study (Ghent) treatment Not Available completed NCT03109717
Structural and Functional Connectivity of Brainstem Monoamine Pathways in Treatment Resistant Depression No drug interventions Not Available Not Available completed NCT03068715
Stanford Accelerated Intelligent Neuromodulation Therapy for Treatment-Resistant Depression (SAINT-TRD) No drug interventions treatment Not Available completed NCT02611206
Repetitive Transcranial Magnetic Stimulation for Adolescent Depression: Efficacy, Predictive Biomarkers, and Mechanisms No drug interventions treatment Not Available completed NCT01913535
Proof-of-Concept Trial of CERC-501 Augmentation of Antidepressant Therapy in Treatment-Resistant Depression treatment 2 terminated NCT01896349
Interpersonal Psychotherapy for Treatment Resistant Depression treatment Not Available unknown_status NCT01801319
A Clinical Evaluation of Subcallosal Cingulate Gyrus Deep Brain Stimulation for Treatment-Resistant Depression No drug interventions treatment Not Available unknown_status NCT01687478
A Study of Olanzapine and Fluoxetine for Treatment-resistant Depression treatment 3 terminated NCT01654796
Trial of Low Field Magnetic Stimulation Augmentation of Antidepressant Therapy in Treatment-Resistant Depression No drug interventions treatment Not Available completed NCT01435148
Deep Brain Stimulation in Treatment Resistant Depression No drug interventions Not Available Not Available unknown_status NCT01383811
Exercise in Treatment Resistant Depression (TRD): A Feasibility Study No drug interventions treatment Not Available completed NCT00789854
Comparing Quetiapine XR Monotherapy and Augmentation With Lithium Augmentation in TRD Patients treatment 3 completed NCT04039022
Open-Label Safety Study of AXS-05 in Subjects With Depression treatment 3 completed NCT02497287
A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression treatment 3 completed NCT04996433
A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients No drug interventions treatment Not Available recruiting NCT05377177
Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression -COMBAT-SI No drug interventions treatment Not Available recruiting NCT01945047
Action of Ketamine in Treatment-Resistant Depression treatment 2 / 3 completed NCT05045378
Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant Depression treatment 4 recruiting NCT05710237
Does Psilocybin Require Psychedelic Effects to Treat Depression? treatment 2 recruiting NCT03564041
SSM vs HEP in Late-Life Depression No drug interventions treatment Not Available terminated NCT05422417
Dorsomedial Prefrontal Neuromodulation in Treatment-resistant Depression No drug interventions treatment Not Available recruiting NCT06372834
Adjuvant Accelerated piTBS for Reducing Suicidal Ideation in TRD Patients No drug interventions treatment Not Available recruiting NCT06542094
Identifying Local Field Potential Biomarkers for Treatment-Resistant Major Depression With Deep Brain Stimulation No drug interventions treatment Not Available recruiting NCT06542900
Efficacy of Deep Brain Stimulation(DBS) for Treatment-Resistant Depression(TRD) No drug interventions treatment Not Available not_yet_recruiting NCT06480201
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression other 1 recruiting NCT06399406
Mindfulness Engaged Neurostimulation for Depression No drug interventions treatment 2 recruiting NCT06255561
pBFS Guided rTMS Over Different Targets for Treatment-Resistant Depression No drug interventions treatment Not Available not_yet_recruiting NCT06230757
Psilocybin for Treatment-Resistant Depression treatment 2 enrolling_by_invitation NCT06166082
Stanford Neuromodulation Therapy (SNT) for the Treatment-Resistant Depression No drug interventions treatment Not Available recruiting NCT06138691
KET-RO Plus RO DBT for Treatment Resistant Depression treatment 1 active_not_recruiting NCT06085950
Transcranial Ultrasonic Stimulation in Treatment-resistant Depression : an Open-label Pilot Trial No drug interventions treatment Not Available recruiting NCT06096207
DBS for Depression No drug interventions treatment 1 suspended NCT06101914
Studying Patterns in Patient Engagement Among Treatment Resistant Depression Patients No drug interventions Not Available Not Available not_yet_recruiting NCT06002204
Studying the Health of Asians to Advance Knowledge, Treatments, and Interventions for Depression No drug interventions Not Available Not Available recruiting NCT05973851
The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. treatment 3 recruiting NCT05809609
Glutamate Emotion Memory Study basic_science Not Available recruiting NCT05811104
Accelerated High-dose Sequential Bilateral Theta Burst Stimulation for Treatment Resistant Depression No drug interventions treatment Not Available not_yet_recruiting NCT05710887
N2O for Acute Suicidality and Depression in the ED treatment 2 not_yet_recruiting NCT05119699
Accelerated TBS in Late Life Depression No drug interventions treatment Not Available recruiting NCT04935489
Accelerated Intermittent Theta Burst Stimulation for Depressed Patients During the Covid-19 Pandemic No drug interventions treatment Not Available completed NCT04971291
An Evaluation of AXS-05 for the Treatment of TRD in Treatment-Adherent Patients treatment 2 unknown_status NCT04805879
The Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Major Depressive Disorder No drug interventions treatment 2 / 3 recruiting NCT04739865
The Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant Depression treatment 2 completed NCT04732169
Cannabidiol for Treatment Resistant Depression treatment 4 withdrawn NCT04739969
Rapid Acting Transcranial Magnetic Stimulation No drug interventions treatment Not Available recruiting NCT04753385
The RECOVER sUb-study, Which Leverages quaNtitative and Credible Research tOols From Verily, Will providE Assessment measuRes for Depressive Episodes No drug interventions Not Available Not Available active_not_recruiting NCT06500533
Combining rTMS and tDCS in Depression: an Exploratory Clinical Trial No drug interventions treatment Not Available recruiting NCT06329414
Acceptability and Feasibility of Transcranial Magnetic Stimulation (TMS) for Depression in Multiple Sclerosis No drug interventions Not Available Not Available recruiting NCT04199143
Brain Reactivity to Nitrous Oxyde in Depression : an MRI and Ultrasound Study (PROTOBRAIN Pilote) basic_science Not Available completed NCT04101474
Role Of Ketamine in Treatment-Resistant Major Depressive Disorder And Its Effect on Suicidality treatment 0 unknown_status NCT04009928
Deep Brain Stimulation for Treatment Resistant Depression No drug interventions treatment 1 / 2 recruiting NCT03991572
rTMS Intervention on Motivational Anhedonia of Treatment Resistant Depression and Brian Network Mechanism No drug interventions treatment Not Available unknown_status NCT03977038
Investigation of the Effects of Repetitive Transcranial Magnetic Stimulation on Cognition in Depression No drug interventions Not Available Not Available completed NCT03923361
Neural and Antidepressant Effects of Propofol (Phase 2) treatment 2 / 3 withdrawn NCT03887715
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression No drug interventions treatment Not Available recruiting NCT03786614
Antidepressant Discontinuation in Treatment Resistant Depression No drug interventions treatment Not Available recruiting NCT04684706
Compressed Intermittent Theta Burst Stimulation No drug interventions other Not Available recruiting NCT03680781
Accelerated Theta Burst in Treatment-Resistant Depression: A Dose Finding and Biomarker Study No drug interventions treatment Not Available enrolling_by_invitation NCT04634669
Open-Label Safety Study of AXS-05 in Subjects With TRD (EVOLVE) treatment 2 completed NCT04850911
Reward Emotion Learning and Ketamine Study basic_science Not Available recruiting NCT04959253
Psilocybin in Depression Resistant to Standard Treatments treatment 2 unknown_status NCT05624268
Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD treatment 3 recruiting NCT05220410
The Safety and Efficacy of Psilocybin in Patients With Treatment-resistant Depression and Chronic Suicidal Ideation treatment 2 recruiting NCT05598931
Development of Neuro-Navigated Transcranial Magnetic Stimulation (TMS) Using MRI No drug interventions Not Available Not Available recruiting NCT05870540
BPL-003 Efficacy and Safety in Treatment Resistant Depression No drug interventions treatment 2 recruiting NCT05849402
Accelerated Intermittent Theta-Burst Stimulation (aiTBS) in Treatment-Resistant Depression of Bipolar II Disorder No drug interventions treatment Not Available recruiting NCT05905705
Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy No drug interventions Not Available Not Available recruiting NCT05900271
Dutch-Depression Outcome Trial Comparing 5 Day Multi Daily Neuronavigated Theta Burst Sessions With 6 Weeks rTMS No drug interventions treatment Not Available recruiting NCT05833087
Schema Therapy for Patients With Chronic Treatment Resistant Depression No drug interventions treatment Not Available recruiting NCT05921929
First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM) No drug interventions other 1 withdrawn NCT05913401
Exercise to Augment TMS in Those With Treatment Resistant Depression No drug interventions treatment Not Available recruiting NCT03428828
Neurofeedback for Treatment Resistant Depression No drug interventions treatment Not Available recruiting NCT03435744
Simvastatin as an Augmentation Treatment for Treatment Resistant Depression: Randomized Controlled Trial. treatment 3 completed NCT03257397
TBS in Major Depression No drug interventions treatment Not Available unknown_status NCT03272698
ECT With Ketamine Anesthesia vs High Intensity Ketamine With ECT Rescue for Treatment-Resistant Depression treatment 4 recruiting NCT03320304
A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression. No drug interventions Not Available Not Available recruiting NCT06132178
Psilocybin rTMS for Treatment Resistant Depression treatment 2 not_yet_recruiting NCT02772211
D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression treatment 4 unknown_status NCT02882711
The UTHealth Ketamine Project treatment 2 terminated NCT02522377
Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant Depression treatment Not Available completed NCT02675556
Allogeneic Human Mesenchymal Stem Cells (hMSCs) Infusion in Patients With Treatment Resistant Depression No drug interventions treatment 1 terminated NCT02150577
Implementation Trial of Evidence Based Practices for Mood Disorders No drug interventions treatment Not Available completed NCT01944644
Low Field Magnetic Stimulation for Treatment Resistant Depression No drug interventions treatment Not Available completed NCT01935115
Comparing Ketamine and Propofol Anesthesia for Electroconvulsive Therapy treatment 4 completed NCT01677078
Coupling Repetitive Transcranial Magnetic Stimulation With a Neuronavigation System in Treatment Resistant Depression No drug interventions treatment Not Available completed NCT01555021
Pharmacogenomics for Antidepressant Guidance and Education No drug interventions Not Available Not Available terminated NCT01246908
Efficacy, Safety and Tolerability of CX157 in Treatment Resistant Depression treatment 2 completed NCT00646087
Ketamine Frequency Treatment for Major Depressive Disorder treatment 4 withdrawn NCT00178854
Risperidone (Risperdal) Augmentation in Depressed Partial Responders to SRI Treatment treatment 4 withdrawn NCT04041479
Biomarker-guided rTMS for Treatment Resistant Depression No drug interventions treatment 3 recruiting NCT06341426
Psilocybin-Assisted Psychotherapy for Treatment-Resistant Depression: Comparing One Versus Two Doses of Psilocybin treatment 2 recruiting NCT05800860
A Trial of GH001 in Patients With Treatment-resistant Depression treatment 2 recruiting NCT03329391
Psychosocial Characteristics and Non-pharmacological Intervention of Patients With Treatment-resistant Depression No drug interventions supportive_care Not Available completed NCT02360280
Efficacy of Repeated Ketamine Infusions for Treatment-resistant Depression treatment 2 completed NCT05095792
Effect of Ketamine on Neurological Activity as Measured by Electroencephalogram (EEG) No drug interventions Not Available Not Available completed NCT04670081
Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression treatment 2 active_not_recruiting NCT02253355
PINS Stimulator System for Patients With Treatment Resistant Depression No drug interventions treatment 0 unknown_status NCT02417064
A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression treatment 3 completed NCT05607654
The Mechanisms of Underlying Accelerated Repetitive Transcranial Magnetic Stimulation for Treatment-resistant Depression No drug interventions basic_science Not Available recruiting NCT02462551
Focal Electrically Administered Seizure Therapy for the Treatment of Depression No drug interventions treatment Not Available unknown_status NCT05661383
Olfactory and Brain Stimulations in Treatment-resistant Depression No drug interventions treatment Not Available recruiting NCT04821271
Antidepressant Effects of TS-161 in Treatment-Resistant Depression No drug interventions treatment 2 completed NCT02418585
A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression treatment 3 completed NCT06172413
Transcranial Alternating Current Stimulation for Treatment-Resistant Depression No drug interventions treatment Not Available not_yet_recruiting NCT06524830
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression No drug interventions treatment 2 not_yet_recruiting NCT06518720
Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND) treatment 2 not_yet_recruiting NCT06512220
Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST) treatment 2 not_yet_recruiting NCT06488586
IV Ketamine Vs. in Esketamine for MDD TRD No drug interventions Not Available Not Available recruiting NCT06350396
pBFS-guided rTMS Over DMPFC for Treatment-Resistant Depression No drug interventions treatment Not Available recruiting NCT06044324
Positron Emission Tomography in Transcranial Magnetic Stimulation Intervention for Treatment-resistant Depression No drug interventions treatment Not Available recruiting NCT06091163
Ketogenic Diet for Treatment-Resistant Depression: Dietary Interventions for MEntal Health Study (DIME) No drug interventions treatment Not Available recruiting NCT05774665
Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression treatment 2 not_yet_recruiting NCT05625555
Predictors of Intravenous Ketamine Response in TRD treatment 3 recruiting NCT05531591
RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT) treatment 4 active_not_recruiting NCT05357040
Antidepressant Effects of Nitrous Oxide treatment 2 recruiting NCT05066672
Phase 2 Study of NV-5138 in Adults With Treatment Resistant Depression treatment 2 recruiting NCT04936126
Comparison of Antidepressant Augmentation With Amantadine vs Pramipexole vs Quetiapine in Treatment Resistant Depression treatment 4 recruiting NCT04781127
Home-administered tDCS for Treatment of Depression No drug interventions treatment 1 completed NCT04727229
Stellate Ganglion Block for Major Depressive Disorder. other 4 completed NCT05139862
Neurocardiac Predictors of Treatment Response to rTMS in Depression No drug interventions treatment Not Available not_yet_recruiting NCT04519957
Long Term Follow Up Study to COMP 001 And COMP 003 Trials (P-TRD LTFU) No drug interventions Not Available Not Available completed NCT04480918
University of Iowa Interventional Psychiatry Service Patient Registry Not Available Not Available recruiting NCT06303739
Psilocybin-Assisted Therapy in Treatment-Resistant Depression treatment 3 recruiting NCT05144789
Personalized Therapeutic Neuromodulation for Anhedonic Depression No drug interventions treatment Not Available recruiting NCT04226963
A Naturalistic Study of Ketamine for Treatment Resistant Mood Disorders Not Available Not Available completed NCT04195308
SAINT for Treatment of Preoperative Depression to Reduce Opioid Use Following Arthroplasty No drug interventions treatment Not Available withdrawn NCT04106466
DBS for TRD With the Medtronic Summit RC+S No drug interventions basic_science Not Available active_not_recruiting NCT04076124
Brain-derived Neurotrophic Factor and the Antidepressant Efficacy of Brain Stimulation No drug interventions treatment Not Available unknown_status NCT03952962
Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression No drug interventions device_feasibility Not Available recruiting NCT03953417
Pilot Accelerated Theta Burst in Treatment-Resistant Bipolar Depression No drug interventions treatment Not Available active_not_recruiting NCT03947827
Minocycline as Adjunctive Treatment for Treatment Resistant Depression treatment 3 recruiting NCT03932825
Nitrous Oxide for Major Depressive Disorder treatment 2 completed NCT04680910
Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) basic_science 1 / 2 recruiting NCT06163625
The Impact of Working Memory and Reward Markers on DLPFC Activity in Treatment-resistant Depression No drug interventions basic_science Not Available recruiting NCT03606395
Safety, Tolerability, PK and Efficacy of Single Doses of NV-5138 in Healthy Volunteers and Subjects With Treatment-Resistant Depression treatment 1 completed NCT03537794
Characterizing Dopamine Receptor Binding in Treatment Resistant Depression No drug interventions Not Available Not Available not_yet_recruiting NCT03191058
Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression No drug interventions treatment Not Available active_not_recruiting NCT05414422
A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of PCN-101 in TRD treatment 2 completed NCT04957368
Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial other 4 completed NCT04956081
Virtual Neuro-Navigation System for Personalized Community Based TMS No drug interventions treatment Not Available recruiting NCT05029466
Psilocybin for Treatment-Resistant Depression treatment 2 completed NCT05418894
Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing No drug interventions basic_science Not Available recruiting NCT05228457
Intensive TMS for Bipolar Depression No drug interventions other Not Available completed NCT05680220
40 Hz Light Neurostimulation for Patients With Depression (FELIX) No drug interventions treatment Not Available recruiting NCT05838560
Dasatinib Plus Quercetin for Accelerated Aging in Mental Disorders prevention 2 recruiting NCT03240692
Stanford Accelerated Intelligent Neuromodulation Therapy for Treatment-Resistant Depression: OL Cohort No drug interventions treatment Not Available completed NCT03290963
Effect of Lithium Versus Placebo in Adults With Treatment-Resistant Depression Who Are Receiving Ketamine basic_science 2 withdrawn NCT03134066
Neurocognitive Features of Patients With Treatment-Resistant Depression No drug interventions Not Available Not Available completed NCT03113968
ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) treatment 2 / 3 completed NCT04124341
PCS in Severe Treatment Resistant Depression No drug interventions treatment Not Available recruiting NCT02810717
Effects of TBS on 5-HT1A Receptor Binding No drug interventions treatment Not Available unknown_status NCT02889250
Deep Brain Stimulation to Relieve Depression No drug interventions treatment 3 withdrawn NCT02935595
Low Dose Intravenous Ketamine in Treatment Resistant Depression Patients treatment 2 completed NCT02960763
Optimizing Outcomes of Treatment-Resistant Depression in Older Adults treatment 4 completed NCT02971150
Treatment Resistant Depression and Insomnia in Older Veterans No drug interventions treatment Not Available completed NCT02974296
Neuroimaging in Patients Undergoing TMS for Depression No drug interventions treatment Not Available completed NCT02046330
Deep Brain Stimulation (DBS) Therapy for Treatment Resistant Depression No drug interventions treatment Not Available active_not_recruiting NCT01984710
Deep Brain Stimulation for Treatment Resistant Depression With the Medtronic Activa PC+S No drug interventions treatment Not Available active_not_recruiting NCT01920555
Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD) treatment 2 completed NCT01898429
Deep Brain Stimulation (DBS) for Treatment-Resistant Depression (TRD) No drug interventions treatment Not Available completed NCT01507155
An Open Label Study of Clinical Utility and Patient Outcomes of the Genecept Assay No drug interventions supportive_care Not Available completed NCT01353092
Pulsating ElectroMagnetive Treatment (PEMF) at Treatment Resistant Depression No drug interventions treatment 3 completed NCT00958568
A Study in Relapse Prevention of Treatment-Resistant Depression treatment 3 completed NCT00808938
A Pilot Study of the Use of Magnetic Seizure Therapy for Depression No drug interventions treatment 2 completed NCT00531726
Berlin Deep Brain Stimulation Depression Study No drug interventions treatment Not Available completed NCT00565617
Epidural Cortical Stimulation for Depression No drug interventions treatment Not Available active_not_recruiting NCT04037592
Dorsomedial Prefrontal Cortex and the Antidepressant Efficacy of Theta Burst Stimulation in Depressed Patients No drug interventions treatment Not Available completed NCT04021823
Neurobiological Analyses Within the FORESEE III Study No drug interventions Not Available Not Available unknown_status NCT01598324
Functional and Neurochemical Correlates of Treatment Response in Major Depressive Disorder No drug interventions Not Available Not Available terminated NCT03701724
Cost-utility Analysis of Maintenance rTMS for Treatment-resistant Depression No drug interventions other Not Available unknown_status NCT03653858
Efficacy Study of Deep Brain Stimulation in Patients With Treatment Resistant Major Depression No drug interventions treatment Not Available recruiting NCT05777876
Early Identification of TRD and Construction and Clinical Validation of NTBS Precision Technology No drug interventions other Not Available recruiting NCT03312894
Efficacy and Safety of TAK-653 in Treatment-Resistant Depression treatment 2 withdrawn NCT05842291
pBFS Guided High-dose rTMS Therapy for Treatment-Resistant Depression No drug interventions treatment Not Available recruiting NCT06232291
Observation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant Depression No drug interventions Not Available Not Available completed NCT05454410
Study of Efficacy, Safety, Tolerability and Pharmacokinetics of MIJ821 in Participants With Treatment- Resistant Depression (TRD) No drug interventions treatment 2 completed NCT00768430
Optimization of IV Ketamine for Treatment Resistant Depression treatment 2 completed NCT05952674
Treatment Resistant Depression and Vagus Nerve Stimulation No drug interventions treatment Not Available not_yet_recruiting