Seizure Disorder, Post Traumatic (DBCOND0106759)

Identifiers

Synonyms

Post Traumatic Epilepsy / Posttraumatic Epilepsy / Post-Traumatic Seizure Disorder / Epilepsy, Post-Traumatic / Post-traumatic Epilepsy / Post-traumatic epilepsy (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Phenytoin	An anticonvulsant drug used in the prophylaxis and control of various types of seizures.	Sodium channel protein type 5 subunit alphatarget Sodium channel protein type 1 subunit alphatarget Cytochrome P450 2C8enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2B6enzyme Cytochrome P450 3A5enzyme Albumincarrier Cytochrome P450 3A4enzyme Solute carrier organic anion transporter family member 1C1transporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 3A7enzyme Nuclear receptor subfamily 1 group I member 2target Sodium channel regulatory subunit beta-1target Sodium channel protein type 3 subunit alphatarget UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1-6enzyme UDP-glucuronosyltransferase 1A9enzyme Thyroxine-binding globulincarrier Voltage-gated inwardly rectifying potassium channel KCNH2target Voltage-dependent L-type calcium channeltarget Sodium channel protein type 2 subunit alphatarget Sodium channel protein type 8 subunit alphatarget GABA(A) Receptortarget Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2E1enzyme Epoxide hydrolase 1enzyme UDP-glucuronosyltransferase 1A4enzyme Catechol O-methyltransferaseenzyme NAD(P)H dehydrogenase [quinone] 1enzyme Cytochrome P450 2C18enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04945213	Biperiden Trial for Epilepsy Prevention	Biperiden	prevention	3	recruiting
NCT01673828	Allopregnanolone for the Treatment of Traumatic Brain Injury	Brexanolone	treatment	2	completed
NCT03441867	Neuroimaging Biomarker for Seizures	No drug interventions	treatment	Not Available	unknown_status
NCT00004817	Phase III Double Blind Trial of Valproate Sodium for Prophylaxis of Post Traumatic Seizures	Phenytoin Valproic acid	treatment	3	completed
NCT03999164	Imaging of Neuro-Inflammation and the Risk for Post-Traumatic Epilepsy	No drug interventions	basic_science	1	recruiting
NCT05353452	Collaborative Care in Posttraumatic Epilepsy	No drug interventions	treatment	Not Available	recruiting
NCT00566046	Prevention of Post-traumatic Seizures With Levetiracetam	Levetiracetam	prevention	3	terminated
NCT01463033	Levetiracetam to Prevent Post-Traumatic Epilepsy	L-Acetylleucine Levetiracetam	prevention	2	completed
NCT06523725	Trial Investigating the Safety and Efficacy of BRC-003 in Refractory Post-Traumatic Epilepsy	Medical Cannabis	treatment	2	not_yet_recruiting
NCT05823766	Transforming Research and Clinical Knowledge in Traumatic Brain Injury Epileptogenesis Project (TRACK-TBI EPI)	No drug interventions	Not Available	Not Available	enrolling_by_invitation