Lipid-Lowering Therapy (DBCOND0112500)

Identifiers

Synonyms

Lipid-lowering treatments / Lipid Lowering Therapy / Lipid-lowering therapy / Lipid-lowering therapy (procedure)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Alirocumab	A PCSK9 inhibitor used as an adjunct to manage heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease in patients who require additional lowering of LDL-cholesterol (LDL-C).	Proprotein convertase subtilisin/kexin type 9target
Atorvastatin	An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.	3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget Cytochrome P450 3A4enzyme Dipeptidyl peptidase 4target Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Solute carrier organic anion transporter family member 1B1transporter ATP-binding cassette sub-family C member 4transporter ATP-binding cassette sub-family C member 5transporter Multidrug resistance-associated protein 1transporter Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Aryl hydrocarbon receptortarget Solute carrier organic anion transporter family member 2B1transporter Solute carrier organic anion transporter family member 1B3transporter UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A3enzyme ATP-binding cassette sub-family C member 2transporter Bile salt export pumptransporter Albumincarrier Histone deacetylase 2target Nuclear receptor subfamily 1 group I member 3target
Bempedoic acid	A drug used in conjunction with lifestyle modification and/or other agents for the treatment of refractory hypercholesterolemia.	ATP-citrate synthasetarget Long-chain fatty acid transport protein 2enzyme Solute carrier organic anion transporter family member 1B1transporter ATP-binding cassette sub-family C member 3transporter Solute carrier organic anion transporter family member 1B3transporter UDP-glucuronosyltransferase 2B7enzyme NUAK family SNF1-like kinase 2enzyme
Evinacumab	A monoclonal antibody targeted against angiopoetin-like protein 3 (ANGPTL3) used as an adjunct with other lipid-lowering therapies for the treatment of homozygous familiar hypercholesterolemia.	Angiopoietin-related protein 3target
Ezetimibe	A cholesterol absorption inhibitor used to lower total cholesterol, LDL-C, Apo-B, and non-HDL-C in primary hyperlipidemia and familial cholesterolemia.	NPC1-like intracellular cholesterol transporter 1target Aminopeptidase Ntarget Sterol O-acyltransferase 1target UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A3enzyme ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 1B1transporter UDP-glucuronosyltransferase 2B15enzyme UDP-glucuronosyltransferase 2B7enzyme Cytochrome P450 3A4enzyme ATP-binding cassette sub-family C member 3transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 2C8enzyme Bile salt export pumptransporter
Rosuvastatin	An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.	3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget Cytochrome P450 2C9enzyme ATP-binding cassette sub-family C member 4transporter Solute carrier organic anion transporter family member 1A2transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 2B1transporter Cystine/glutamate transportertransporter Solute carrier organic anion transporter family member 1B1transporter Bile salt export pumptransporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Albumincarrier ATP-binding cassette sub-family C member 2transporter Organic anion transporter 3transporter Hepatic sodium/bile acid cotransportertransporter Integrin alpha-Ltarget
Simvastatin	An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular events including myocardial infarction and stroke.	3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A5enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Solute carrier organic anion transporter family member 1B1transporter Cytochrome P450 2B6enzyme Cytochrome P450 2D6enzyme UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 2B7enzyme ATP-binding cassette sub-family C member 2transporter Integrin alpha-Ltarget Bile salt export pumptransporter Cytochrome P450 2C19enzyme Solute carrier organic anion transporter family member 2B1transporter Solute carrier organic anion transporter family member 1B3transporter Histone deacetylase 2target Cocaine esteraseenzyme Liver carboxylesterase 1enzyme

Clinical Trials

Not Available