Giant Cell Arteritis (GCA) (DBCOND0115353)

Identifiers

Synonyms
Arteritis, Giant Cell / Giant Cells Arteritis / Giant Cell Arteritis / Horton's Disease / Horton Disease / Temporal arteritis (disorder) / Horton's arteritis / Temporal arteritis / Cranial arteritis

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Prednisone
A corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases.
Tocilizumab
An interleukin-6 (IL-6) receptor antagonist used to treat Cytokine Release Syndrome (CRS), Systemic Juvenile Idiopathic Arthritis (sJIA), Giant Cell Arteritis (GCA), and Rheumatoid Arthritis (RA).
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04930094
Phase III Study of Efficacy and Safety of Secukinumab Versus Placebo, in Combination With Glucocorticoid Taper Regimen, in Patients With Giant Cell Arteritis (GCA)treatment3active_not_recruiting
NCT06609668
Pilot Study Evaluating the Value of Thrombomodulin in Ruling Out the Diagnosis of Giant Cell Arteritis (GCA) in Pseudo Rheumatoid Arthritis (PRA) (THROPIQ)No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03725202
A Study to Evaluate the Safety and Efficacy of Upadacitinib in Participants With Giant Cell Arteritistreatment3active_not_recruiting
NCT05479448
Predictive Factors for Treatment Response in Patients With Newly-diagnosed Polymyalgia Rheumatica and Giant Cell ArteritisNo drug interventionsNot AvailableNot Availableunknown_status
NCT03841734
Study of the Benefit of Early Treatment With an Endothelin Inhibitor (Bosentan) in Patients With Sudden Blindness Due to Giant Cell Arteritis: CECIBOtreatment3unknown_status
NCT03026504
Baricitinib in Relapsing Giant Cell Arteritistreatment2completed
NCT02844023
Biomarkers in Giant Cells ArteritisNo drug interventionsotherNot Availableterminated
NCT02257866
Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic VasculitisNo drug interventionsNot AvailableNot Availablerecruiting
NCT05703763
The Applanation Tonometry in GCA PilotNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05749094
Optic Nerve Sheath Ultrasound in Giant Cell ArteritisNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06130540
Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Intravenous Secukinumab in Patients With GCA or PMRtreatment1recruiting
NCT05380453
Efficacy and Safety of Secukinumab in Patients With New Onset of Giant Cell Arteritis Who Are in Clinical Remissiontreatment3recruiting
NCT01400464
Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritistreatment4unknown_status
NCT03812302
Use of Gallium-68 HA-DOTATATE PET/CT in Giant Cell Arteritis (GCA)No drug interventionsdiagnostic2completed
NCT03482479
Low Dose Naltrexone to Improve Physical Health in Patients With Vasculitistreatment2recruiting
NCT06004154
Post-therapeutic Imaging Evaluation of Patients With Horton's Disease (Giant Cell Arteritis) (EvHortim)No drug interventionsNot AvailableNot Availablerecruiting
NCT05865054
Vessel Wall Enhancement in Giant Cell ArteritisNo drug interventionsNot AvailableNot Availablerecruiting
NCT01791153
An Efficacy and Safety Study of Tocilizumab (RoActemra/Actemra) in Participants With Giant Cell Arteritis (GCA)treatment3completed
NCT04335747
COVID-19 Infection in Vulnerable Patients With Inflammatory Rheumatic DiseasesNo drug interventionsNot AvailableNot Availableterminated
NCT04633447
A Study to Evaluate Guselkumab for the Treatment of Participants With New-onset or Relapsing Giant Cell Arteritistreatment2terminated
NCT02955147
Ustekinumab for the Treatment of Giant Cell Arteritistreatment1 / 2terminated
NCT03600805
Evaluation of Efficacy and Safety of Sarilumab in Patients With GCAtreatment3terminated
NCT04012905
Giant Cell Arteritis: Comparison Between Two Standardized Corticosteroids TaperingNo drug interventionstreatment3not_yet_recruiting
NCT00974883
Temporal Artery Biopsy vs ULtrasound in Diagnosis of GCA (TABUL)No drug interventionsNot AvailableNot Availablecompleted
NCT00138983
Prevention of Glucocorticoid-Induced Osteoporosis in Rheumatic Diseases: Alendronate Versus Alfacalcidol.prevention3completed
NCT06500728
Visual Involvement in Giant Cell ArteritisNo drug interventionsNot AvailableNot Availablerecruiting
NCT03765788
A Placebo-controlled Phase 2 Trial to Investigate the Safety and Efficacy of Secukinumab in Giant Cell Arteritistreatment2completed
NCT03244709
Tocilizumab Dose-tapering and Interruption in Patients With Giant Cell Arteritis Achieving the Clinical Remission.treatment4unknown_status
NCT01795456
Carotid Artery Neovascularization in Takayasu's and Giant Cell ArteritisNo drug interventionsNot AvailableNot Availablecompleted
NCT01450137
Tocilizumab for Patients With Giant Cell Arteritistreatment2completed
NCT04397237
Prevalence and Seroconversion of COVID-19 in Autoimmune Diseases in EuropeNo drug interventionsNot AvailableNot Availableunknown_status
NCT05168475
Biologics in Refractory Vasculitistreatment2active_not_recruiting
NCT06460142
Assessing Biomarker in Giant Cell Arteritis and Polymyalgia RheumaticNo drug interventionsNot AvailableNot Availablerecruiting
NCT05248906
Giant Cell Arteritis - Optimization of DiagnosticsNo drug interventionsNot AvailableNot Availableunknown_status
NCT03726749
Tocilizumab Plus a Short Prednisone Taper for GCAtreatment4completed
NCT03827018
KPL-301 for Subjects With Giant Cell Arteritistreatment2completed
NCT06271018
TocILizumab in aorTitis in GCA (TILT)No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT02985424
Polymyalgia Rheumatica and Giant Cell ArteritisNo drug interventionsNot AvailableNot Availableunknown_status
NCT00004686
Phase II Randomized Study of Glucocorticoids With or Without Methotrexate for Treatment of Giant Cell Arteritistreatment2completed
NCT00556439
Abatacept for Treating Adults With Giant Cell Arteritis and Takayasu's Arteritistreatment2completed
NCT00305539
HECTHOR: Humira to Spare Steroids in Giant Cell Arteritistreatment3completed
NCT06279065
Investigation of the Influence of the Human Microbiome on Giant Cell ArteritisNo drug interventionsNot AvailableNot Availablerecruiting
NCT03656627
Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer and Pre-existing Autoimmune Diseasetreatment1terminated
NCT04204876
Longitudinal Imaging in Patients With Large Vessel Vasculitis to Predict Further Disease CourseNo drug interventionsNot AvailableNot Availablecompleted
NCT04071691
PET Imaging of Giant Cell and Takayasu ArteritisNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT02190929
Educational Needs of Patients With Systemic VasculitisNo drug interventionsNot AvailableNot Availablecompleted
NCT03658889
Assessment of Giant Cell Arteritis Medical Practices in FranceNo drug interventionsNot AvailableNot Availablecompleted
NCT05246540
Evaluation of PET/CT of Cephalic Arteries for the Diagnosis of Giant Cell ArteritisNo drug interventionsNot AvailableNot Availablecompleted
NCT05045001
Pharmacogenetic Studies on Anti-IL-6 Receptor Monoclonal Antibodies on the Treatment of Rheumatic DiseasesNo drug interventionsNot AvailableNot Availableunknown_status
NCT03202368
An Extension Study to Evaluate Long-Term Safety of Subcutaneous (SC) Tocilizumab in Participants With Giant Cell Arteritis (GCA)treatment3completed
NCT03192969
A Study to Evaluate Efficacy and Safety of Subcutaneous Abatacept With Steroid Treatment Compared to Steroid Treatment Alone in Adults With Giant Cell Arteritis (GCA)treatment3withdrawn
NCT06011512
Risk of Diabetes Mellitus in Patients With Giant Cell Arthritis and Polymyalgia Rheumatica.No drug interventionsNot AvailableNot Availablerecruiting
NCT05435781
Effect of Supplemental Hydrocortisone During Stress in Prednisolone-induced Adrenal Insufficiencytreatment4recruiting
NCT00006055
Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune DiseasestreatmentNot Availableunknown_status
NCT01066208
American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic VasculitisNo drug interventionsNot AvailableNot Availableunknown_status
NCT03923738
A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Tocilizumab (TCZ) Administered to Participants With Giant Cell Arteritis (GCA).treatment1completed
NCT03410290
Journey of Patients With Vasculitis From First Symptom to DiagnosisNo drug interventionsNot AvailableNot Availablecompleted
NCT04554290
Giant Cell Arteritis and Differential Diagnoses Associated With Positive Temporal Artery BiopsyNo drug interventionsNot AvailableNot Availablecompleted
NCT04888221
Efficacy of Tocilizumab in Association to Steroids in Giant Cell Arteritis With Cerebro-vascular Involvementtreatment3recruiting
NCT02531633
Efficacy and Safety Study of Sirukumab in Patients With Giant Cell Arteritistreatment3terminated
NCT05663333
Histopathological Analysis of Temporal Artery Biopsy Following Dynamic Full-field Optical Coherence Tomography, a Comparison to Conventional Histopathological Findings in Patients With Suspected Giant Cell Arteritis (DOCTA)No drug interventionsNot AvailableNot Availablecompleted
NCT04474847
Abatacept for the Treatment of Giant Cell Arteritistreatment3recruiting
NCT03285945
FDG Uptake in Large-Vessel Giant Cell Arteritis After Short-term, High-Dose Steroid TreatmentNo drug interventionsNot AvailableNot Availablecompleted
NCT01241305
One-Time DNA Study for VasculitisNo drug interventionsNot AvailableNot Availablerecruiting
NCT02771483
Giant Cell Arteritis and PET Scan (GAPS) StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT01588483
Prospective Follow-up Study of the Aortic Diameter in Patients With Giant Cell ArteritisNo drug interventionsNot AvailableNot Availablecompleted
NCT03840928
PatientSpot Formerly Known as ArthritisPowerNo drug interventionsNot AvailableNot Availablerecruiting
NCT04049071
TARGET GCAT RegistryNo drug interventionsNot AvailableNot Availableterminated
NCT06335888
A Clinical Trial to Investigate 18F-AzaFol in the Diagnosis of Large Vessel VasculitisNo drug interventionsdiagnostic2not_yet_recruiting
NCT00430807
Hydroxychloroquine in Giant Cell ArteritisNo drug interventionstreatment3completed
NCT05935709
DANIsh VASculitis Database (DANIVAS)No drug interventionsNot AvailableNot Availablerecruiting
NCT03892785
MEthotrexate Versus TOcilizumab for Treatment of GIant Cell Arteritis: a Multicenter, Randomized, Controlled Trialtreatment3active_not_recruiting
NCT04142515
Collection and Analysis of the Clinical and Biological Characteristics of Patients Treated for Giant Cells ARTEitis (Horton's Disease)No drug interventionsNot AvailableNot Availablecompleted
NCT02176070
Reproductive Health in Men and Women With VasculitisNo drug interventionsNot AvailableNot Availablecompleted
NCT02190942
VCRC Patient Contact Registry Patient-Reported Data Validation StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT03409913
Diagnostic Accuracy of FDG PET/CT of Cranial Arteries in GCANo drug interventionsNot AvailableNot Availablecompleted
NCT03765424
Evaluation of Ultrasound and PET/CT in the Diagnosis and Monitoring of Giant Cell ArteritisNo drug interventionsNot AvailableNot Availablecompleted
NCT02190916
Vasculitis Illness Perception (VIP) StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT04239196
Efficacy of Tocilizumab for the Treatment of Acute AION Related to GCAtreatment2unknown_status
NCT04402086
Rheumatology Patient Registry and BiorepositoryNo drug interventionsNot AvailableNot Availablerecruiting
NCT03745586
Giant Cell Arteritis Treatment With Ultra-short Glucocorticoids and Tocilizumabtreatment1 / 2completed
NCT02703922
Validation of a Diagnostic Algorithm of Giant Cell ArteritisNo drug interventionsdiagnosticNot Availablecompleted
NCT02523625
Giant Cell Arteritis: Improving Use of Ultrasound EvaluationNo drug interventionsNot AvailableNot Availableunknown_status
NCT04102930
Clinical and Immunogenetic Characterization of Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR)No drug interventionsNot AvailableNot Availablerecruiting
NCT00076726
A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Giant Cell Arteritistreatment2terminated
NCT04664465
PRediction Of DIverse Glucocorticoids toxIcity OUtcomeSNo drug interventionsNot AvailableNot Availableunknown_status
NCT02902731
Giant Cell Arteritis and Anakinra Trialtreatment3unknown_status
NCT05854927
Impact of the Spatial Resolution of Several Contrast-enhanced 3D T1-WI Sequences When Diagnosing Giant Cell Arteritis (GCA)No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06037460
TocilizuMab discontinuAtion in GIant Cell Arteritistreatment3recruiting
NCT04519580
Improved Diagnostics and Monitoring of Polymyalgia RheumaticaNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04885829
Comparative Study of 3 Tocilizumab Products in Normal Healthy Volunteeerstreatment1completed
NCT05623592
Methotrexate as Remission Maintenance Therapy After Remission-Induction With Tocilizumab and Glucocorticoids in Giant Cell Arteritistreatment2active_not_recruiting
NCT05904301
Armenian NAtionwide REGistry of Systemic Autoimmune and Autoinflammatory DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT02967068
VCRC Tissue RepositoryNo drug interventionsNot AvailableNot Availablerecruiting
NCT06244069
Clonal Hematopoiesis in Giant Cell ArteritisNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04204512
Comparison of 22Mhz and 18Mhz High-frequency Probes for the Ultrasound Study of Temporal Arteries in Patients Suspected of Having Giant Cell ArteritisNo drug interventionsNot AvailableNot Availablecompleted
NCT02333708
Study of Circulating Microparticles in Giant Cell ArteritisNo drug interventionsNot AvailableNot Availableunknown_status
NCT05000138
FDG Digital PET/CT as First Line Investigation for Giant Cell ArteritisNo drug interventionsNot AvailableNot Availablerecruiting
NCT01910038
Evaluation of Tocilizumab as an add-on Therapy to Corticoids in Giant Cell Arteritis: Proof of Concept Study.treatment2completed
NCT02065297
Quantitative and Functional Study of TH17 Lymphocytes in Horton's Disease (HD)No drug interventionsNot AvailableNot Availablecompleted
NCT04390126
COVID-19 Related Lockdown Effects On Chronic DiseasesNo drug interventionsNot AvailableNot Availableunknown_status
NCT02857192
Study of Phenotypic and Functional Characteristics of Regulatory T Lymphocytes in Horton's DiseaseNo drug interventionsotherNot Availablecompleted
NCT02158208
Study of the T CD8 Immune Response in Horton's DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT03313102
Study of T Lymphocytes in Patients With Horton DiseaseNo drug interventionsotherNot Availablerecruiting
NCT04010097
Chewing Gum Test for the Diagnosis of Giant Cell Arteritis (Horton's Disease) - ChewingHortNo drug interventionsdiagnosticNot Availableunknown_status
NCT03360162
Velocimetric Study of Temporal Arteries in Patients With Horton Disease Using Scan-DopplerNo drug interventionsNot AvailableNot Availablecompleted
NCT02473029
Interest of Medical Imaging in the Diagnostic Strategy Vis a Vis a Suspected Horton DiseaseNo drug interventionsNot AvailableNot Availableterminated