Transplanted Organ Rejection (DBCOND0120716)

Identifiers

Synonyms
Transplant Rejection / Organ Transplant Rejection / Graft Rejection / Rejection, Transplant / Transplant rejections / Organ Rejection Transplants / Transplanted organ rejection / Transplanted organ rejection (disorder) / Graft rejection (finding)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Cyclosporine
A steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis.
Mycophenolate mofetil
An inosine monophosphate dehydrogenase inhibitor used to prevent the rejection of kidney, heart, or liver transplants.
Prednisolone
A glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.
Prednisolone acetate
A glucocorticoid used to treat a wide variety of endocrine, inflammatory, and immune conditions as well as for palliation of neoplastic conditions.
Sirolimus
An mTOR inhibitor immunosuppressant used to prevent organ transplant rejections, treat lymphangioleiomyomatosis, and treat adults with perivascular epithelioid cell tumors.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT00117689
Evaluation of Thymoglobulin Induction and Reduced Doses of Calcineurin Inhibitors on Liver Transplant Rejectionprevention2completed
NCT00001984
Effectiveness of the Investigational Drug Campath-1H in Preventing Rejection of Transplanted Kidneystreatment2completed
NCT06281587
Pathogenetic Risk Factors for Corneal Graft RejectionNo drug interventionsNot AvailableNot Availablecompleted
NCT00761787
Cardiac Allograft Rejection Gene Expression Observational (CARGO) II STUDYNo drug interventionsNot AvailableNot Availablecompleted
NCT00895583
Study Evaluating A Planned Transition From Tacrolimus To Sirolimus In Kidney Transplant Recipientsprevention4completed
NCT01035593
Recombinant Human C1 Inhibitor for the Treatment of Early Antibody-Mediated Rejection in Renal Transplantationtreatment2withdrawn
NCT00273871
Study Comparing Conversion From Calcineurin Inhibitors to Rapamune Versus Standard Therapy in Established Renal Allograft Recipientstreatment3completed
NCT05285878
Fingolimod for the Abrogation of Interstitial Fibrosis and Tubular Atrophy Following Kidney Transplantationtreatment2enrolling_by_invitation
NCT00751309
Lung Allograft Rejection Gene Expression Observational (LARGO) StudyNo drug interventionsNot AvailableNot Availableterminated
NCT00000137
Collaborative Corneal Transplantation Studies (CCTS)No drug interventionstreatment3completed
NCT01009619
Azithromycin in Bronchiolitis Obliterans Syndromeprevention4completed
NCT00001858
Monitoring for Tolerance to Kidney or Combined Kidney-Pancreas TransplantsNo drug interventionsNot AvailableNot Availablecompleted
NCT00106925
Long-term Evaluation and Follow-up Care of Patients Treated With Stem Cell TransplantsNo drug interventionsNot AvailableNot Availablerecruiting
NCT03147157
The Effect of Human Leukocyte Antigen Macthing on Guiding Tacrolimus Regimen After Liver TransplantationNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT00300274
Efficacy and Safety of Everolimus in Recipients of Heart Transplants to Prevent Acute and Chronic Rejectiontreatment3completed
NCT00261820
Study Comparing Two Immunosuppressive Regimens in De Novo Renal Allograft Recipientstreatment4completed
NCT04164576
Study of the Pathogenicity and Humoral Immune Response Induced by BK Virus in Lung Transplant RecipientsNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00807144
Standard Versus Prolonged-release Tacrolimus Monotherapy After Alemtuzumab Induction in Kidney Transplantationprevention4completed
NCT05333367
MORPHEE : Mechanisms of Cell Death Induced by Extracorporeal PhotochemotherapyNo drug interventionsbasic_scienceNot Availableunknown_status
NCT00290069
Renal Function Optimization With Mycophenolate Mofetil (MMF) Immunosuppressor Regimes (ALHAMBRA)treatment4unknown_status
NCT00035555
Study Comparing the Safety and Efficacy of Belatacept With That of Cyclosporine in Patients With a Transplanted Kidneyprevention2completed
NCT00266123
Study Comparing Two Sirolimus Regimens vs. Tacrolimus and Mycophenolate Mofetil Regimen in Kidney Transplant Recipientstreatment4completed
NCT06532890
Optimal Pediatric Heart Transplant Immunosuppression With MicroRNAs (OPTIMA)No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00476164
Study of Rituximab to Treat Chronic Renal Transplant Rejectiontreatment4completed
NCT01147302
A Pilot Study to Evaluate the Use of C1 Esterase Inhibitor (Human) in Patients With Acute Antibody-Mediated Rejectiontreatment2completed
NCT05072951
Urine Biomarker for Kidney Transplant RejectionNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00962377
A Comparison of AlloMap Molecular Testing and Traditional Biopsy-based Surveillance for Heart Transplant Rejection Early Post-transplantationNo drug interventionsdiagnosticNot Availableunknown_status
NCT00089947
A Study to Evaluate the Effect of Thymoglobulin and Reduced Doses of Steroids to Prevent Renal Transplant Rejectiontreatment2completed
NCT04851145
Mass Spectrometry-based Proteomics in Microvascular Inflammation Diagnosis in Kidney Transplantation.No drug interventionsdiagnosticNot Availablerecruiting
NCT05689905
Immunologic Risk of Pregnancy in Women With Lung Transplantion : a National Multicentric StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05913583
Correlation Between Pre-transplant ICI Exposure and Post-transplant Graft RejectionNo drug interventionsNot AvailableNot Availablerecruiting
NCT00619528
HLA-Identical Sibling Renal Transplant TolerancetreatmentNot Availableactive_not_recruiting
NCT02469207
Regenerative Cellular Therapies, Physiology, Pathology and Developmental BiologyNo drug interventionsNot AvailableNot Availableunknown_status
NCT00254709
Study Evaluating Two Different Sirolimus-based Immunosuppressive Regimens in Elderly Kidney Transplant Recipientstreatment4completed
NCT01211509
Montelukast in Bronchiolitis Obliterans Syndrometreatment4completed
NCT00351559
IMAGE: A Comparison of AlloMap Molecular Testing and Traditional Biopsy-based Surveillance for Heart Transplant RejectionNo drug interventionsdiagnosticNot Availablecompleted
NCT00771875
Randomized Trial for Mixed Acute Rejectiontreatment2completed
NCT00510913
A Study to Compare the Conversion to Prograf® (Tacrolimus) to the Continuation of Cyclosporine in Patients at Risk for Chronic Renal Allograft Failureprevention4completed
NCT00450996
Analysis of a Beneficial Effect of Prolonges Topical Steroid Treatment After Low-risk Penetrating KeratoplastyNo drug interventionspreventionNot Availablecompleted
NCT00369382
Study Of The Safety And Efficacy Of Conversion From A CNI To Sirolimus In Renally-Impaired Heart Transplant Recipientsprevention4completed
NCT04488094
Diagnostic Validity of [18F]FSPG PET for the Assessment of Acute Rejection After Heart or Liver TransplantationNo drug interventionsdiagnostic2completed
NCT00331162
Study of Alemtuzumab Versus Anti-thymocyte Globulin to Help Prevent Rejection in Kidney and Pancreas Transplantationprevention4completed
NCT00706680
Thymoglobulin in Calcineurin Inhibitor and Steroid Minimization Protocolprevention4unknown_status
NCT01066689
Impact of Treatment With Rituximab on the Progression of Humoral Acute Rejection After Renal Transplantationtreatment3unknown_status
NCT00251004
Efficacy and Safety Study of Everolimus Plus Reduced Cyclosporine Versus Mycophenolic Acid Plus Cyclosporine in Kidney Transplant Recipientstreatment3completed
NCT00097968
Safety/Efficacy of Everolimus and Neoral® in Adult Cardiac Transplant Patients With Established Allograft Vasculopathyprevention3completed
NCT00498095
A Study on a New Staining Method (C4d Staining) of Transplanted Kidney BiopsiesNo drug interventionsNot AvailableNot Availablecompleted
NCT03995901
A Safety and Efficacy Study of FCR001 vs Standard of Care in de Novo Living Donor Kidney Transplantationtreatment3terminated
NCT03255265
Clinical Study of Microchimerism and cfDNA as Biomarkers for Acute Rejection After Organ TransplantationNo drug interventionsNot AvailableNot Availableunknown_status
NCT03626714
Safety and Pharmacokinetics of Sustained-release Depot Tacrolimus: A First-in-human Studytreatment0completed
NCT04615221
Immunological Mechanisms of Rejection in Uterine TransplantationNo drug interventionsotherNot Availablerecruiting
NCT01338779
Study of Tolerant Kidney Transplant RecipientsNo drug interventionsNot AvailableNot Availablecompleted
NCT01236378
Study To Evaluate Pharmacokinetics Of Sirolimus In Stable Renal Transplant Recipientstreatment1completed
NCT05156710
BIVV020 (SAR445088) n Prevention and Treatment of Antibody-mediated Rejection (AMR)treatment2recruiting
NCT03984747
Study for the Prediction of Active Rejection in Organs Using Donor-derived Cell-free DNA DetectionNo drug interventionsNot AvailableNot Availablerecruiting
NCT04046549
A Study to Evaluate the Safety and Efficacy of Dual Costimulation Blockade With VIB4920 and Belatacept for Prophylaxis of Allograft Rejection in Adults Receiving a Kidney Transplantprevention2completed
NCT03582436
Rejection Diagnosis in Kidney Transplants PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT01766050
Study to Evaluate Effect of Belatacept on Pharmacokinetics of Inje Cocktail in Healthy Volunteersbasic_science4completed
NCT05215288
Expanded Access for Use of ExoFlo in Abdominal Solid Organ Transplant PatientsNo drug interventionsNot AvailableNot Availableno_longer_available