Opioid Withdrawal (Disorder) (DBCOND0122432)

Identifiers

Synonyms

Opioid Withdrawal / Opiate withdrawal / Opiate withdrawal symptoms / Opioid withdrawal (disorder) / Opioid withdrawal syndrome (disorder) / Drug withdrawal syndrome

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Chloral hydrate	A mild hypnotic used for experimental purposes that was previously used for the treatment of insomnia.	No drug targets
Clonidine	An alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines.	Alpha-2A adrenergic receptortarget Cytochrome P450 2D6enzyme Alpha-2B adrenergic receptortarget Alpha-2C adrenergic receptortarget Solute carrier family 22 member 3transporter Organic cation/carnitine transporter 2transporter Solute carrier family 22 member 4transporter Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Cytochrome P450 1A1enzyme Cytochrome P450 3A5enzyme Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Alpha-1D adrenergic receptortarget Albumincarrier Amine oxidase [copper-containing] 3target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06047834	Pharmacokinetic and Safety Study of Oral Lofexidine in Neonates Experiencing Opioid Withdrawal Due to Intrauterine Exposure to Opioids	Lofexidine	supportive_care	2	recruiting
NCT04070157	Randomized, Double-Blind, Placebo-Controlled Pilot Study on the Safety and Effectiveness of LUCEMYRA During an Opioid Taper in Treatment of Withdrawal	Lofexidine	treatment	2	suspended
NCT05053503	Delivering Transcutaneous Auricular Neurostimulation to Improve Relapse Prevention in Opioid Use Disorder	Lofexidine Naltrexone	prevention	Not Available	recruiting
NCT05712707	Sublingual Dexmedetomidine for Treating Opioid Withdrawal	No drug interventions	treatment	1 / 2	recruiting
NCT05790551	Suboxone Dispenser for OUD	No drug interventions	treatment	Not Available	recruiting
NCT06487533	Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT04759703	Treatment of Restless Legs Symptoms With Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal in OUD	Pramipexole	treatment	2 / 3	recruiting
NCT04238754	Oral Cannabidiol for Opioid Withdrawal	Cannabidiol	treatment	1 / 2	completed
NCT04162145	BRIDGE Device for Treatment of Opioid Withdrawal	No drug interventions	treatment	Not Available	terminated
NCT04126083	Lofexidine for Adults Undergoing Lumbar Spine Surgery	Lofexidine	treatment	4	completed
NCT03489161	Feasibility of the Utilization of Buprenorphine in the Emergency Room to Treat Clinical Opioid Withdrawal	Buprenorphine	treatment	0	completed
NCT02548728	Oxytocin Treatment of Opioid Dependence	Oxytocin	treatment	1 / 2	completed
NCT05511909	Evaluating Buspirone to Treat Opioid Withdrawal	Buspirone Lofexidine	treatment	2	recruiting
NCT04325659	An Innovative Intervention for OUD Treatment	Lofexidine	treatment	2 / 3	recruiting
NCT04049799	Maternal Opioid Treatment: Human Experimental Research - Data Yield Appropriate Decisions	No drug interventions	Not Available	Not Available	completed
NCT04740099	Surviving Opioid Overdose With Naloxone Education and Resuscitation Trial (SOONER)	No drug interventions	health_services_research	Not Available	withdrawn
NCT05307458	Evaluating the Pharmacokinetics and Patient Outcomes of Buprenorphine Microdosing	Buprenorphine Naloxone	Not Available	Not Available	recruiting
NCT04731935	Novel Earpiece for Transcutaneous Auricular Neurostimulation (tAN) for Symptoms of Opioid Withdrawal	No drug interventions	treatment	Not Available	completed
NCT03678792	Comparison of Three Opioid Detoxification Treatment Regimens	Buprenorphine Morphine Naloxone Tramadol	treatment	3	withdrawn
NCT03174067	Buprenorphine in the Emergency Department	Buprenorphine Clonidine	treatment	4	completed
NCT04075214	Transcutaneous Auricular Neurostimulation (tAN) for Symptoms of Opioid Withdrawal	No drug interventions	treatment	Not Available	completed
NCT04470050	Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal	Dexmedetomidine	treatment	1 / 2	completed
NCT02363998	Open-Label, Safety Study of Lofexidine	Lofexidine	treatment	3	completed
NCT05555485	Understanding the Effects of Transcutaneous Auricular Neurostimulation for Treatment of Chronic Pain	No drug interventions	treatment	Not Available	recruiting
NCT04080037	Assessing Opioid Care Practices Using CPV Patient Simulation Modules	No drug interventions	health_services_research	Not Available	completed
NCT01549652	5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence	Morphine Naloxone Ondansetron	treatment	Not Available	completed
NCT05027919	Assessing a Clinically-meaningful Opioid Withdrawal Phenotype	Lofexidine Morphine Naloxone	basic_science	2	recruiting
NCT03485430	Tapering From Long-term Opioid Therapy in Chronic Pain Population. Randomized Controlled Trial With 12 Months Follow up	No drug interventions	supportive_care	Not Available	active_not_recruiting
NCT03017430	Pregabalin for Opiate Withdrawal Syndrome	1,2-Benzodiazepine Clonidine Ketorolac Loperamide Metoclopramide Phenazepam Pregabalin	treatment	4	completed
NCT06442566	ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain	Buprenorphine	treatment	1 / 2	not_yet_recruiting
NCT01262092	Effects of Gabapentin Versus Placebo on Buprenorphine Detoxification of Opioid-dependent Individuals	Buprenorphine Gabapentin Naloxone	treatment	2	completed
NCT04218240	Combining Pregabalin (LYRICA®) With Lofexidine (LUCEMYRATM) to Treat OPIOID Withdrawal	Lofexidine Pregabalin	treatment	2	completed
NCT03813095	Exploratory Dose Ranging Study Assessing APH-1501 for the Treatment of Opioid Addiction	No drug interventions	treatment	2	not_yet_recruiting
NCT03789214	Medical Management of Sleep Disturbance During Opioid Tapering	Suvorexant	treatment	2	completed
NCT04140955	Opioid Tapering After Spine Surgery	No drug interventions	treatment	Not Available	completed