Systemic Mastocytosis With an Associated Hematological Neoplasm (DBCOND0135968)

Identifiers

Synonyms

ASM with associated hematological neoplasm / Systemic Mastocytosis With an Associated Hematologic Neoplasm / Systemic mastocytosis with associated hematological neoplasm / Systemic mastocytosis with an associated hematological neoplasm

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Avapritinib	A selective tyrosine kinase inhibitor being investigated for the treatment of multidrug resistant gastrointestinal tumors.	Mast/stem cell growth factor receptor Kittarget ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 3A4enzyme Cytochrome P450 2C9enzyme Bile salt export pumptransporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Platelet-derived growth factor receptor alphatarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06327685	Avapritinib With Decitabine in Patients With SM-AHN	Avapritinib Cedazuridine Decitabine	treatment	1	recruiting
NCT05219266	Managed Access Programs for PKC412, Midostaurin	Midostaurin	Not Available	Not Available	no_longer_available
NCT03580655	(PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis	Avapritinib	treatment	2	active_not_recruiting
NCT04695431	Retrospective Study Assessing the Effect of Avapritinib Versus Best Available Therapy in Patients With AdvSM	No drug interventions	Not Available	Not Available	completed