Activated PI3 kinase delta syndrome (DBCOND0156285)

Identifiers

Synonyms

Activated PI3Kdelta Syndrome APDS / Activated PI3K-delta Syndrome / Activated PI3K-delta syndrome (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Leniolisib	A phosphoinositide 3-kinase-delta inhibitor that is used to treat activated phosphoinositide 3-kinase delta syndrome.	Cytochrome P450 1A2enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter ATP-dependent translocase ABCB1transporter Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 2D6enzyme Cytochrome P450 1A1enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02593539	Safety, Pharmacokinetic (PK) and Pharmacodynamic (PD) Study of Repeat Doses of Inhaled Nemiralisib in Patients With APDS/PASLI	Nemiralisib	treatment	2	completed
NCT03383380	Rapamycin Treatment for Activated Phosphoinositide 3-Kinase δ Syndrome	Sirolimus	treatment	1 / 2	completed