Natamycin is a macrolide antifungal used to treat fungal infections of the eye. Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis.
- Mechanism
- Curator reviewed
Like other polyene antibiotics, Natamycin inhibits fungal growth by binding to sterols. Specifically, Natamycin binds to ergosterol in the plasma membrane, preventing ergosterol-dependent fusion of vacuoles, as well as membrane fusion and fission. This differs from the mechanism of most other polyene antibiotics, which tend to work by altering fungal membrane permeability instead.
- Primary indication
- For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.Curator reviewed · 3 structured indications
- Formula / weight
- C33H47NO13 · 665.733 g/mol (avg)
- First approval
- United States, 1980
- Also known as
- Pimaracin · Pimaricin
- Code names
- A-5283 · Antibiotic A-5283 · CL 12,625 · E-235 · INS-235 · INS NO.235
- Brand names
Resolves to
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Which other approved drugs treat the same conditions as Natamycin, and which companies have late-stage candidates in those indications?
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