Interferon gamma-1b is a form of recombinant human interferon used to treat infections associated with chronic granulomatous disease and to slow the progression of severe malignant osteopetrosis. Human Interferon gamma-1b (140 residues), produced from E. coli.
- Mechanism
- Curator reviewed
Binds directly to the type II interferon gamma receptor IFNGR1, leading to a complex of IFNGR1 and IFNGR2. This activates JAK1 and JAK2 kinases which form a STAT1 docking site. This leads to STAT1 phosphorylation, nuclear translocation and initiation of gene transcription of multiple immune-related genes.
- Primary indication
- Interferon gamma-1b is used for the treatment of Chronic granulomatous disease and Osteopetrosis.Curator reviewed · 2 structured indications
- Formula / weight
- C761H1206N214O225S6 · 17145.6 Da
- First approval
- United States, 1999
- Also known as
- IFN-gamma 1b · IFN-gamma-1b · Interferon gamma 1-b · Interferon gamma-1b, recombinant · Interferon gamma-2a
- Brand names
Resolves to
What you can answer from here — as of July 17, 2026
Which drugs share a target with Interferon gamma-1b, and which of those have an active Phase 3 trial?
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