Cetrorelix is a synthetic peptide antagonist of gonadotropin releasing hormone used to prevent luteinizing hormone surges in women undergoing assisted reproduction therapy. Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH).
- Mechanism
- Curator reviewed
Cetrorelix binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion. It competes with natural GnRH for binding to membrane receptors on pituitary cells and thus controls the release of LH and FSH in a dose-dependent manner.
- Primary indication
- For the inhibition of premature LH surges in women undergoing controlled ovarian stimulationCurator reviewed · 1 structured indication
- Formula / weight
- C70H92ClN17O14 · 1431.038 g/mol (avg)
- First approval
- Canada, 2003 · United States, 2000 · European Union, 2016
- Code names
- SB-75
- Brand names
Resolves to
SBNPWPIBESPSIF-MHWMIDJBSA-NSMILESCC(C)C[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC1=CN=CC=C1)NC(=O)[C@@H](CC1=CC=C(Cl)C=C1)NC(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=OWhat you can answer from here — as of September 12, 2026
Which drugs share a target with Cetrorelix, and which of those have an active Phase 3 trial?
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