Hyaluronidase (ovine) is a purified form of sheep hyaluronidase enzyme used as an adjunct in subcutaneous rehydration therapy and to increase absorption of other drugs and radiopaque imaging agents. Highly purified sheep hyaluronidase for administration by injection into the vitreous of the eye.
- Mechanism
- Curator reviewed
Hyaluronidase is a spreading or diffusing substance. It increase the permeability of connective tissue through the hydrolysis of hyaluronic acid. Hyaluronidase hydrolyzes hyaluronic acid by splitting the glucosaminidic bond between C1 of the glucosamine moiety and C4 of glucuronic acid. This temporarily decreases the viscosity of the cellular cement and increases diffusion of injected fluids or of localized transudates or exudates, thus facilitating their absorption.
- Primary indication
- For increase of absorption and distribution of other injected drugs and for rehydration.Curator reviewed · 16 structured indications
- Formula / weight
- C2455H3775N617O704S21 · 53870.9 Da
- First approval
- United States, 2004
- Also known as
- Hyaluronidase (glycoprotein, sheep testis isoenzyme) · Hyaluronidase (sheep testis isoenzyme) · Hyaluronidase, ovine · Ovine hyaluronidase
- Code names
- HYO-6A
- Brand names
Resolves to
What you can answer from here — as of July 17, 2026
Which drugs share a target with Hyaluronidase (ovine), and which of those have an active Phase 3 trial?
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