Indecainide

DB00192ApprovedSmall molecule

Indecainide is a rarely used antidysrhythmic. Indecainide has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the...

Mechanism: Indecainide acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.
Curator reviewed
Primary indication: For the treatment of life-threatening dysrhythmias and sustained ventricular tachycardia.Curator reviewed
Formula / weight: C₂₀H₂₄N₂O · 308.4174 g/mol (avg)

Resolves to

Compound

UNII3AZF20DM1TCAS74517-78-5ChEMBLCHEMBL1201242ChEBI135314PubChem52195

Clinical / RWD

PharmGKBPA164754881

Structure

InChIKeyUCEWGESNIULAGX-UHFFFAOYSA-NSMILESCC(C)NCCCC1(C(N)=O)C2=CC=CC=C2C2=CC=CC=C12

Targets

Q14524SCN5A

What you can answer from here — as of September 16, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

8+ReferencesStructured and connected to the statements they support

Which drugs share a target with Indecainide, and which of those have an active Phase 3 trial?

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