Guanadrel

DB00226ApprovedSmall molecule

Guanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent.

Mechanism: Guanadrel is an adrenergic neuron inhibitor that slowly displaces norepinephrine from its storage in nerve endings. It blocks the release of norepinephrine in response to the sympathetic nerve stimulation, leading to reduced arteriolar vasoconstriction, especially the reflex increase in sympathetic tone that occurs with a change in position.
Curator reviewed
Primary indication: Used to treat and control hypertension.Curator reviewed
Formula / weight: C₁₀H₁₉N₃O₂ · 213.2768 g/mol (avg)

Resolves to

Compound

Clinical / RWD

Structure

InChIKeyHPBNRIOWIXYZFK-UHFFFAOYSA-NSMILESNC(N)=NCC1COC2(CCCCC2)O1

Targets

What you can answer from here — as of September 19, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

640Drug interactionsStructured to mechanism, not free text

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Guanadrel, and which of those have an active Phase 3 trial?

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