Clomocycline

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DB00453ExperimentalSmall molecule

Clomocycline is a tetracycline used to treat bacterial infections.

Mechanism: Clomocycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Clomocycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane.
Curator reviewed
Primary indication: For the treatment and management of Brucellosis, mycoplasma infection, acne vulgaris, chlamydial infection;Chronic bronchitisCurator reviewed
Formula / weight: C₂₃H₂₅ClN₂O₉ · 508.906 g/mol (avg)
Also known as: Chlormethylenecycline

Resolves to

Compound

UNIIYP0241BU76CAS1181-54-0ChEMBLCHEMBL2106071ChEBI59589PubChem54680675KEGGD06885

Clinical / RWD

RxNorm21272ATCJ01AA11PharmGKBPA164771235

Structure

InChIKeyGJGDLRSSCNAKGL-KMVLDZISSA-NSMILES[H][C@@]12C[C@@]3([H])C(=C(O)[C@]1(O)C(=O)C(C(=O)NCO)=C(O)[C@H]2N(C)C)C(=O)C1=C(C(Cl)=CC=C1O)[C@@]3(C)O

Targets

P0A7V8rpsDP0A7X3rpsI

What you can answer from here — as of September 20, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

352Drug interactionsStructured to mechanism, not free text

1ATC codeIncluding every combination product, plus 6 drug categories

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Clomocycline, and which of those have an active Phase 3 trial?

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