Loteprednol is a corticosteroid indicated in the treatment of pain and inflammation after cataract surgery. A more commonly used formulation of loteprednol is its ester, loteprednol etabonate.
- Mechanism
- Curator reviewed · 4 references
The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation. Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days. Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive. High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels.
- Formula / weight
- C21H27ClO5 · 394.889 g/mol (avg)
Resolves to
YPZVAYHNBBHPTO-MXRBDKCISA-NSMILES[H][C@@]12CC[C@](O)(C(=O)OCCl)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@]12CWhat you can answer from here — as of September 13, 2026
Which drugs share a target with Loteprednol, and which of those have an active Phase 3 trial?
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