Rolitetracycline

DB01301ApprovedWithdrawnSmall molecule

Rolitetracycline is a broad-spectrum tetracycline antibiotic used in cases needing high concentrations or when oral administration is impractical.

Mechanism: Rolitetracycline is a semisynthetic broad-spectrum tetracycline antibiotic used especially for parenteral administration in cases requiring high concentrations or when oral administration is impractical. Rolitetracycline passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis.
Curator reviewed
Primary indication: Rolitetracycline is a broad-spectrum antibiotic used in cases needing high concentrations or when oral administration is impractical.Curator reviewed
Formula / weight: C₂₇H₃₃N₃O₈ · 527.5662 g/mol (avg)
First approval: Canada, 1959
Code names: SQ-15659

Resolves to

Compound

UNIIGH9IW85221CAS751-97-3ChEMBLCHEMBL1237046ChEBI63334PubChem54682938KEGGD02282

Clinical / RWD

RxNorm9462ATCJ01AA09ATCJ01AA20PharmGKBPA164779049

Structure

InChIKeyHMEYVGGHISAPJR-IAHYZSEUSA-NSMILES[H][C@@]12C[C@@]3([H])C(C(=O)C4=C(O)C=CC=C4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(=O)NCN1CCCC1)=C(O)[C@H]2N(C)C

Targets

P0A7X3rpsI

What you can answer from here — as of September 20, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

286Drug interactionsStructured to mechanism, not free text

14ContraindicationsEach with its own population and attribute set

3Marketed productsAcross 2 countries and 2 labellers

2ATC codesIncluding every combination product, plus 7 drug categories

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Rolitetracycline, and which of those have an active Phase 3 trial?

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