Pristinamycin IIA is a macrolide antibiotic, a member of the streptogramin A group of antibiotics, and one component of pristinamycin. It is produced by Streptomyces graminofaciens and other bacteria.
- Mechanism
- Curator reviewed
Virginiamycin M1 is a macrocyclic lactone antibiotic that acts syngeristically with the structurally unrelated cyclic depsipeptides more commonly known as the virginiamycins B (ostreogrycin B or streptogramin B) and S to inhibit peptide elongation. This is achieved by blocking formation of a peptide bond between the growing peptide chain (peptidyl-tRNA) linked to the 50S ribosome and aminoacyl-tRNA. Virginiamycin M1 has proven to be highly active against Gram positive bacteria, particularly methicillin-resistant S. aureus.
- Primary indication
- For the treatment of bacterial infections.Curator reviewed
- Formula / weight
- C28H35N3O7 · 525.5934 g/mol (avg)
- Also known as
- Mikamycin A · Ostreogrycin A · Pristinamycin IIA · Streptogramin A · Virginiamycin factor M1
- Code names
- NSC-244426 · NSC-87432 · PA-114A · RP-12536
Resolves to
DAIKHDNSXMZDCU-FQTGFAPKSA-NSMILESCC(C)[C@H]1OC(=O)C2=CCCN2C(=O)C2=COC(=N2)CC(=O)C[C@H](O)\C=C(/C)\C=C\CNC(=O)\C=C\[C@H]1CWhat you can answer from here — as of September 13, 2026
Which drugs share a target with Virginiamycin M1, and which of those have an active Phase 3 trial?
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