Propylene glycol
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Explore a selection of our essential drug information below, or:
Overview
- DrugBank ID
- DB01839
- Type
- Small Molecule
- Clinical Trials
- Phase 0
- 5
- Phase 1
- 37
- Phase 2
- 74
- Phase 3
- 54
- Phase 4
- 86
Identification
- Brand Names
- Leader Lubricant Eye Drops, QC ultra lubricant eye, Systane, Systane Balance
- Generic Name
- Propylene glycol
- DrugBank Accession Number
- DB01839
- Background
A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
- Weight
- Average: 76.0944
Monoisotopic: 76.0524295 - Chemical Formula
- C3H8O2
- Synonyms
- 1,2-dihydroxypropane
- 1,2-Propanediol
- 1,2-Propylenglykol
- 2-hydroxypropanol
- isopropylene glycol
- methyl glycol
- methylethyl glycol
- methylethylene glycol
- monopropylene glycol
- Propane-1,2-diol
- Propylene glycol
- α-propyleneglycol
- External IDs
- E-1520
- INS NO.1520
- INS-1520
- NSC-69860
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Prophylaxis of Dry eyes ••• ••• ••••••••• •••••••• Symptomatic treatment of Dry eyes ••• ••• ••••••••• •••••••• Used in combination for symptomatic treatment of Dry eyes Combination Product in combination with: Hyaluronic acid (DB08818), Polyethylene glycol 400 (DB11077) •••••••••••• •••••••• Used in combination for symptomatic treatment of Dry eyes Combination Product in combination with: Polyethylene glycol 400 (DB11077) ••• ••• Used in combination to manage Dry eyes Combination Product in combination with: Glycerin (DB09462) ••• ••• - Associated Therapies
- Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UB12-independent glycerol dehydratase Not Available Clostridium butyricum - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
Pathway Category Pyruvate Kinase Deficiency Disease Pyruvate Metabolism Metabolic Leigh Syndrome Disease Pyruvate Dehydrogenase Complex Deficiency Disease Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Disease Primary Hyperoxaluria II, PH2 Disease - Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAntihemophilic factor (recombinant), PEGylated The therapeutic efficacy of Antihemophilic factor (recombinant), PEGylated can be decreased when used in combination with Propylene glycol. Certolizumab pegol The therapeutic efficacy of Certolizumab pegol can be decreased when used in combination with Propylene glycol. Damoctocog alfa pegol The therapeutic efficacy of Damoctocog alfa pegol can be decreased when used in combination with Propylene glycol. Elapegademase The therapeutic efficacy of Elapegademase can be decreased when used in combination with Propylene glycol. Lipegfilgrastim The therapeutic efficacy of Lipegfilgrastim can be decreased when used in combination with Propylene glycol. - Food Interactions
- No interactions found.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Propylene glycol diacetate 5Z492UNF9O 623-84-7 MLHOXUWWKVQEJB-UHFFFAOYSA-N - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Advanced Eye Relief/ Dry Eye/ Rejuvenation Lubricant Solution / drops 9.5 mg/1mL Ophthalmic Bauch & Lomb Incorporated 2010-01-01 2010-01-31 US Artificial Tears Solution / drops 9.5 mg/1mL Ophthalmic Rite Aid Corporation 2010-09-01 2015-08-31 US Baby Wipes Cloth 1 g/1 Topical Shandong Yayun Sanitary Products Co., Ltd. 2020-03-30 Not applicable US CVS Health Lubricant Drops Solution / drops 0.06 mg/1mL Ophthalmic Velocity Pharma Llc 2021-11-11 Not applicable US CVS Lubricant Eye Drops 15mL Liquid 0.6 g/100mL Ophthalmic CVS PHARMACY 2019-09-20 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image (badiful) Antibacterial Wipes Propylene glycol (2 mg/100mL) + Benzalkonium chloride (13 mg/100mL) + Cetylpyridinium chloride (5 mg/100mL) + Chlorphenesin (2 mg/100mL) Swab Topical ZHANGZHOU KANGBEI HYGIENIC PRODUCTS CO., LTD. 2020-05-31 Not applicable US Advanced Eye Relief Dry Eye Rejuvenation Propylene glycol (10 mg/1mL) + Glycerin (3 mg/1mL) Solution / drops Ophthalmic Bausch & Lomb Incorporated 2010-09-01 Not applicable US Alcohol disinfectant wipes Propylene glycol (0.5 g/801) + Benzalkonium chloride (0.5 g/801) + Ethanol (230 mL/801) + Methylisothiazolinone (0.5 g/801) + Phenoxyethanol (0.5 g/801) Cloth Extracorporeal Zhejiang Huanghua Biological Technology Co., Ltd 2020-08-10 Not applicable US Alcohol disinfectant wipes Propylene glycol (0.5 g/501) + Benzalkonium chloride (0.5 g/501) + Ethanol (160 mL/501) + Methylisothiazolinone (0.5 g/501) + Phenoxyethanol (0.5 g/501) Cloth Extracorporeal Zhejiang Huanghua Biological Technology Co., Ltd 2020-11-26 Not applicable US Alcohol disinfectant wipes Propylene glycol (1.98 g/101) + Benzalkonium chloride (2.475 g/101) + Ethanol (202.5 mL/101) + Methylisothiazolinone (5.85 mg/101) + Phenoxyethanol (0.44491 g/101) Cloth Extracorporeal Zhejiang Huanghua Biological Technology Co., Ltd 2020-05-21 2020-05-21 US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image (badiful) Antibacterial Wipes Propylene glycol (2 mg/100mL) + Benzalkonium chloride (13 mg/100mL) + Cetylpyridinium chloride (5 mg/100mL) + Chlorphenesin (2 mg/100mL) Swab Topical ZHANGZHOU KANGBEI HYGIENIC PRODUCTS CO., LTD. 2020-05-31 Not applicable US Disinfectant Cleaning Wipes Propylene glycol (0.12 g/1601) + Benzalkonium chloride (0.12 g/1601) + Ethylhexylglycerin (0.12 g/1601) + Glycerin (0.12 g/1601) + Phenoxyethanol (0.6 g/1601) Cloth Extracorporeal Reynard (Ningbo) Biotechnology Co., Ltd. 2020-04-17 2020-05-29 US Disinfectant Cleaning Wipes Propylene glycol (0.12 g/1601) + Benzalkonium chloride (0.12 g/1601) + Didecyldimethylammonium chloride (0.24 g/1601) + Ethylhexylglycerin (0.12 g/1601) + Glycerin (0.12 g/1601) + Phenoxyethanol (0.6 g/1601) Cloth Extracorporeal Reynard (Ningbo) Biotechnology Co., Ltd. 2020-06-12 Not applicable US Disinfectant Cleaning Wipes Propylene glycol (0.12 g/1601) + Benzalkonium chloride (0.12 g/1601) + Ethylhexylglycerin (0.12 g/1601) + Glycerin (0.12 g/1601) + Phenoxyethanol (0.6 g/1601) Cloth Extracorporeal Reynard (Ningbo) Biotechnology Co., Ltd. 2020-04-17 2020-05-29 US Disinfecting Wipes Propylene glycol (0.12 g/1601) + Benzalkonium chloride (0.12 g/1601) + Didecyldimethylammonium chloride (0.24 g/1601) + Ethylhexylglycerin (0.12 g/1601) + Glycerin (0.12 g/1601) + Phenoxyethanol (0.6 g/1601) Cloth Extracorporeal Reynard (Ningbo) Biotechnology Co., Ltd. 2020-04-17 Not applicable US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as 1,2-diols. These are polyols containing an alcohol group at two adjacent positions.
- Kingdom
- Organic compounds
- Super Class
- Organic oxygen compounds
- Class
- Organooxygen compounds
- Sub Class
- Alcohols and polyols
- Direct Parent
- 1,2-diols
- Alternative Parents
- Secondary alcohols / Primary alcohols / Hydrocarbon derivatives
- Substituents
- 1,2-diol / Aliphatic acyclic compound / Hydrocarbon derivative / Primary alcohol / Secondary alcohol
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- propane-1,2-diols, glycol (CHEBI:16997) / DL-12-Propanediol (PROPANE-1-2-DIOL)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 6DC9Q167V3
- CAS number
- 57-55-6
- InChI Key
- DNIAPMSPPWPWGF-UHFFFAOYSA-N
- InChI
- InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3
- IUPAC Name
- propane-1,2-diol
- SMILES
- CC(O)CO
References
- Synthesis Reference
Rudolf Huettinger, Ulrich Holtschmidt, "Polyoxyalkylene ethers of glycerin or 1,2-propanediol, esterified with fatty acid and/or isostearic acid, their synthesis and use as thickening or solubilizing agents." U.S. Patent US4614622, issued June, 1968.
US4614622- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0001881
- KEGG Drug
- D00078
- KEGG Compound
- C00583
- PubChem Compound
- 1030
- PubChem Substance
- 46505685
- ChemSpider
- 13835224
- 34693
- ChEBI
- 16997
- ChEMBL
- CHEMBL286398
- Wikipedia
- Propylene_glycol
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Active Not Recruiting Treatment Insomnia Chronic 1 somestatus stop reason just information to hide Not Available Approved for Marketing Not Available Liver Disease 1 somestatus stop reason just information to hide Not Available Approved for Marketing Not Available Total Parenteral Nutrition-Induced Cholestasis 3 somestatus stop reason just information to hide Not Available Completed Not Available Dry Eye Syndrome (DES) 3 somestatus stop reason just information to hide Not Available Completed Not Available Hypertension 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Swab Topical Solution / drops Ophthalmic 9.5 mg/1mL Gel Topical Liquid Topical Cloth Topical 1 g/1 Cream Cutaneous Syrup Oral 11.8 g/1U Cloth Extracorporeal Lotion Topical Solution, gel forming / drops Ophthalmic Emulsion Cutaneous Solution / drops Ophthalmic 6 mg/1mL Liquid Ophthalmic Cream Topical 0.1 g/1g Gel Cutaneous Solution Ophthalmic Solution / drops Ophthalmic 0.6 g/100mL Cream Topical 19 g/100g Aerosol, spray Nasal Solution Conjunctival; Ophthalmic Liquid Cutaneous Spray Cutaneous Liquid Ophthalmic 0.6 g/100mL Gel Nasal Aerosol, metered Nasal Liquid Topical 23.85 mL/150mL Spray Topical Solution Cutaneous Cloth Topical Gel Extracorporeal Spray, metered Nasal Liquid Nasal Liquid Extracorporeal Spray Nasal Cream Topical Solution / drops Ophthalmic Gel Ophthalmic Emulsion Ophthalmic 0.06 mg/1mL Solution / drops Ophthalmic .06 mg/1mL Kit; solution Ophthalmic Solution Ophthalmic; Topical Emulsion Ophthalmic 6 mg Solution Conjunctival; Ophthalmic 6 mg Emulsion Ophthalmic 0.6 g/100mL Shampoo Topical 10 g/500mL Solution Conjunctival; Topical Liquid Auricular (otic) Solution / drops Ophthalmic 0.06 mg/1mL Solution / drops Ophthalmic 0.05 g/100mL Lotion Cutaneous Solution - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) -60 °C PhysProp boiling point (°C) 187.6 °C PhysProp water solubility 1E+006 mg/L (at 20 °C) YALKOWSKY,SH & DANNENFELSER,RM (1992) logP -0.92 HANSCH,C ET AL. (1995) pKa 14.9 SERJEANT,EP & DEMPSEY,B (1979) - Predicted Properties
Property Value Source Water Solubility 952.0 mg/mL ALOGPS logP -1.1 ALOGPS logP -0.79 Chemaxon logS 1.1 ALOGPS pKa (Strongest Acidic) 14.47 Chemaxon pKa (Strongest Basic) -2.9 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 40.46 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 18.97 m3·mol-1 Chemaxon Polarizability 8.01 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9832 Blood Brain Barrier + 0.7184 Caco-2 permeable - 0.6594 P-glycoprotein substrate Non-substrate 0.7162 P-glycoprotein inhibitor I Non-inhibitor 0.9157 P-glycoprotein inhibitor II Non-inhibitor 0.944 Renal organic cation transporter Non-inhibitor 0.9401 CYP450 2C9 substrate Non-substrate 0.832 CYP450 2D6 substrate Non-substrate 0.8739 CYP450 3A4 substrate Non-substrate 0.7434 CYP450 1A2 substrate Non-inhibitor 0.7858 CYP450 2C9 inhibitor Non-inhibitor 0.9388 CYP450 2D6 inhibitor Non-inhibitor 0.9526 CYP450 2C19 inhibitor Non-inhibitor 0.8969 CYP450 3A4 inhibitor Non-inhibitor 0.9599 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.958 Ames test Non AMES toxic 0.9132 Carcinogenicity Carcinogens 0.5 Biodegradation Ready biodegradable 0.9505 Rat acute toxicity 0.6112 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9568 hERG inhibition (predictor II) Non-inhibitor 0.9008
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 104.0060753 predictedDarkChem Lite v0.1.0 [M-H]- 121.78371 predictedDeepCCS 1.0 (2019) [M+H]+ 104.6241753 predictedDarkChem Lite v0.1.0 [M+H]+ 123.88966 predictedDeepCCS 1.0 (2019) [M+Na]+ 104.1247753 predictedDarkChem Lite v0.1.0 [M+Na]+ 132.127 predictedDeepCCS 1.0 (2019)
Targets
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1. DetailsB12-independent glycerol dehydratase
- Kind
- Protein
- Organism
- Clostridium butyricum
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- lyase activity
- Gene Name
- dhaB1
- Uniprot ID
- Q8GEZ8
- Uniprot Name
- B12-independent glycerol dehydratase
- Molecular Weight
- 88046.08 Da
Drug created at June 13, 2005 13:24 / Updated at April 26, 2024 04:15