Cocarboxylase

DB01987ApprovedInvestigationalSmall molecule

The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.

Chemical structure of Cocarboxylase
Mechanism
Curator reviewed
Formula / weight
C12H18N4O7P2S · 424.306 g/mol (avg)
First approval
United States, 2015
Also known as
Thiamine diphosphate · Thiamine pyrophosphate
Brand names
  • EnBrace HR
  • EnLyte

Resolves to

Compound
UNIIQ57971654YCAS136-08-3ChEMBLCHEMBL1236235ChEBI45931PubChem5431KEGGC00068
Clinical / RWD
RxNorm10459
Structure
InChIKeyAYEKOFBPNLCAJY-UHFFFAOYSA-NSMILESCC1=C(CCO[P@](O)(=O)O[P@](O)([O-])=O)SC=[N+]1CC1=CN=C(C)N=C1N
Targets
P27696budBP0AFG8aceEP94692porP23234ipdCQ9LCV9ceaSP27302tktA

What you can answer from here — as of September 13, 2026

7Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
4Clinical trialsPhase, status and sponsor resolved per trial
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15Structured indicationsCondition, population, route and combination as fields, not prose
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21Marketed productsAcross 5 countries and 8 labellers
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9+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Cocarboxylase, and which of those have an active Phase 3 trial?

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