D-Methionine

Identification

Name
D-Methionine
Accession Number
DB02893
Description
Not Available
Type
Small Molecule
Groups
Approved, Experimental, Investigational
Structure
Thumb
Weight
Average: 149.211
Monoisotopic: 149.051049291
Chemical Formula
C5H11NO2S
Synonyms
Not Available
External IDs
  • MRX-1024
  • NSC-45689

Pharmacology

Indication
Not Available
Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
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Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
UMethionine aminopeptidase 2Not AvailableHumans
UTranscriptional regulator, HTH_3 familyNot AvailableVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
20% ProsolD-Methionine (0.76 g) + Alanine (2.76 g) + Arginine (1.96 g) + Aspartic acid (0.6 g) + Glutamic acid (1.02 g) + Glycine (2.06 g) + Histidine (1.18 g) + Isoleucine (1.08 g) + L-Lysine (1.35 g) + Leucine (1.08 g) + Methionine (0.76 g) + Phenylalanine (1 g) + Proline (1.34 g) + Serine (1.02 g) + Threonine (0.98 g) + Tryptophan (0.32 g) + Tyrosine (0.05 g) + Valine (1.44 g)LiquidIntravenousBaxter Laboratories1996-10-09Not applicableCanada flag
Nutrineal Pd4D-Methionine (85 mg) + Alanine (95.1 mg) + Arginine (107.1 mg) + Calcium chloride (18.4 mg) + Glycine (51 mg) + Histidine (71.4 mg) + Isoleucine (85 mg) + L-Lysine (95.5 mg) + Sodium lactate (448 mg) + Leucine (102 mg) + Magnesium chloride (5.1 mg) + Methionine (85 mg) + Phenylalanine (57 mg) + Proline (59.5 mg) + Serine (51 mg) + Sodium chloride (538 mg) + Threonine (64.6 mg) + Tryptophan (27 mg) + Tyrosine (30 mg) + Valine (139.3 mg)LiquidHemodialysisBaxter Laboratories1998-09-25Not applicableCanada flag

Categories

Drug Categories
Not Available
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as methionine and derivatives. These are compounds containing methionine or a derivative thereof resulting from reaction of methionine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Methionine and derivatives
Alternative Parents
D-alpha-amino acids / Thia fatty acids / Amino acids / Sulfenyl compounds / Monocarboxylic acids and derivatives / Dialkylthioethers / Carboxylic acids / Organopnictogen compounds / Organic oxides / Monoalkylamines
show 2 more
Substituents
Aliphatic acyclic compound / Alpha-amino acid / Amine / Amino acid / Carbonyl group / Carboxylic acid / D-alpha-amino acid / Dialkylthioether / Fatty acid / Fatty acyl
show 15 more
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
D-alpha-amino acid, methionine (CHEBI:16867) / Other amino acids (C00855)

Chemical Identifiers

UNII
868496F25R
CAS number
348-67-4
InChI Key
FFEARJCKVFRZRR-SCSAIBSYSA-N
InChI
InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m1/s1
IUPAC Name
(2R)-2-amino-4-(methylsulfanyl)butanoic acid
SMILES
CSCC[[email protected]@H](N)C(O)=O

References

Synthesis Reference

Maria-Regina Kula, Matthias Kittelmann, "Method of using N-acetyl-2,3-Didehydroleucine acylase for the preparation of D- or L-tryptophyl glycine, D- or L-tryptophyl-D-methionine or L-tryptophyl-D-cysteine." U.S. Patent US5212069, issued July, 1992.

US5212069
General References
Not Available
KEGG Compound
C00855
PubChem Compound
84815
PubChem Substance
46505884
ChemSpider
76512
ChEBI
57932
ChEMBL
CHEMBL1234268
ZINC
ZINC000001532766
PDBe Ligand
MED
PDB Entries
1kq0 / 1tkj / 1y9q / 1zue / 2q33 / 3gp4 / 3tjw / 3trv / 3try / 4gls
show 19 more

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3TerminatedPreventionHearing Loss, Noise-Induced2
1TerminatedTreatmentHead and Neck Carcinoma / Mucositis / Resected Head and Neck Cancer / Squamous Cell Carcinoma (SCC)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
LiquidIntravenous
LiquidHemodialysis
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)213 dec °CPhysProp
Predicted Properties
PropertyValueSource
Water Solubility23.9 mg/mLALOGPS
logP-1.8ALOGPS
logP-2.2ChemAxon
logS-0.8ALOGPS
pKa (Strongest Acidic)2.53ChemAxon
pKa (Strongest Basic)9.5ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area63.32 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity37.59 m3·mol-1ChemAxon
Polarizability15.46 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
PropertyValueProbability
Human Intestinal Absorption+0.9797
Blood Brain Barrier+0.8447
Caco-2 permeable-0.6698
P-glycoprotein substrateNon-substrate0.5351
P-glycoprotein inhibitor INon-inhibitor0.9802
P-glycoprotein inhibitor IINon-inhibitor0.9919
Renal organic cation transporterNon-inhibitor0.8913
CYP450 2C9 substrateNon-substrate0.7875
CYP450 2D6 substrateNon-substrate0.7323
CYP450 3A4 substrateNon-substrate0.7008
CYP450 1A2 substrateNon-inhibitor0.8295
CYP450 2C9 inhibitorNon-inhibitor0.9489
CYP450 2D6 inhibitorNon-inhibitor0.9567
CYP450 2C19 inhibitorNon-inhibitor0.951
CYP450 3A4 inhibitorNon-inhibitor0.9758
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9938
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.9224
BiodegradationReady biodegradable0.5613
Rat acute toxicity0.6483 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9725
hERG inhibition (predictor II)Non-inhibitor0.9655
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0udi-2900000000-67e023372cdbac09cb36
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0udi-9800000000-1e589df1b14865d84d74
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-056r-9000000000-efb0cddabddaf5231dbd
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0002-6900000000-9ef89c92bce71adb0b81
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0002-9300000000-8507980760c8afb7f454
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0002-9000000000-544c2c943904dcca737e
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Poly(a) rna binding
Specific Function
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala...
Gene Name
METAP2
Uniprot ID
P50579
Uniprot Name
Methionine aminopeptidase 2
Molecular Weight
52891.145 Da
References
  1. Nonato MC, Widom J, Clardy J: Human methionine aminopeptidase type 2 in complex with L- and D-methionine. Bioorg Med Chem Lett. 2006 May 15;16(10):2580-3. Epub 2006 Mar 15. [PubMed:16540317]
Kind
Protein
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Pharmacological action
Unknown
General Function
Transcription factor activity, sequence-specific dna binding
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q9KQN0
Uniprot Name
Transcriptional regulator, HTH_3 family
Molecular Weight
20353.97 Da

Drug created on June 13, 2005 07:24 / Updated on June 12, 2020 10:52

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