alpha-Ketoisocaproic acid

DB03229ExperimentalSmall molecule

alpha-Ketoisocaproic acid is an amino acid used to manage chronic renal failure and for nutritional therapy in acute renal dysfunction.

Chemical structure of alpha-Ketoisocaproic acid
Formula / weight
C6H10O3 · 130.1418 g/mol (avg)
Also known as
2-oxo-4-methylpentanoic acid · 2-Oxoisocaproate · 2-oxoleucine · 4-Methyl-2-oxopentanoate · 4-methyl-2-oxopentanoic acid

Resolves to

Compound
UNII4GUJ8AH400CAS816-66-0ChEMBLCHEMBL445647ChEBI48430PubChem70KEGGC00233
Structure
InChIKeyBKAJNAXTPSGJCU-UHFFFAOYSA-NSMILESCC(C)CC(=O)C(O)=O
Targets
P18548cefEP17584D-2-hydroxyacid dehydrogenase (NAD+)

What you can answer from here — as of September 13, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action
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2Structured indicationsCondition, population, route and combination as fields, not prose
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2ContraindicationsEach with its own population and attribute set
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1Marketed productAcross 1 country and 1 labeller
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5+ReferencesStructured and connected to the statements they support
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Which drugs share a target with alpha-Ketoisocaproic acid, and which of those have an active Phase 3 trial?

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