Geneticin

DB04263ExperimentalSmall molecule

Geneticin (also known as G418) is an aminoglycoside antibiotic similar in structure to gentamicin B1, produced by Micromonospora rhodorangea. Geneticin blocks polypeptide synthesis by inhibiting the elongation step in both... Geneticin blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells and is commonly used in laboratory research to select genetically engineered cells.

Mechanism: Pharmacologically active on Ornithine decarboxylase
Curator reviewed
Formula / weight: C₂₀H₄₀N₄O₁₀ · 496.5524 g/mol (avg)
Code names: Antibiotic G-418 · G-418

Resolves to

Compound

UNIIA08F5XTI6GCAS49863-47-0ChEMBLCHEMBL215226PubChem123865KEGGC17703

Structure

InChIKeyBRZYSWJRSDMWLG-DJWUNRQOSA-NSMILES

[H][C@]1(O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)O[C@]([H])([C@@H](C)O)[C@@H](O)[C@H](O)[C@H]1N

Targets

P11926ODC1

What you can answer from here — as of August 31, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

876Drug interactionsStructured to mechanism, not free text

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with Geneticin, and which of those have an active Phase 3 trial?

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