Streptolydigin

DB04785ExperimentalSmall molecule

Streptolydigin is an antibiotic isolated from culture filtrates of Streptomyces lydicus. It is active against gram-postive bacteria except micrococci.

Mechanism: Pharmacologically active on DNA-directed RNA polymerase subunit beta and DNA-directed RNA polymerase subunit beta'
Curator reviewed
Formula / weight: C₃₂H₄₄N₂O₉ · 600.6998 g/mol (avg)
Also known as: Afragilimycin A · Portamycin
Code names: Antibiotic D-45 · NSC-3360

Resolves to

Compound

UNII6MON4029Q8CAS7229-50-7ChEMBLCHEMBL1236068ChEBI45773PubChem54708748

Structure

InChIKeyKVTPRMVXYZKLIG-NCAOFHFGSA-NSMILES

[H][C@@]1([C@H](C)C(=O)NC)N([C@@H]2CC[C@H](O)[C@H](C)O2)C(=O)\C(=C(\O)/C=C/C(/C)=C/[C@@H](C)[C@@]2([H])O[C@@]3(C)O[C@H](C=C[C@@]33CO3)[C@@H]2C)C1=O

Targets

P0A8V2rpoBQ8RQE9rpoBQ8RQE8rpoCP0A8T7rpoCP04053DNTT

What you can answer from here — as of July 03, 2026

5Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

56Drug interactionsStructured to mechanism, not free text

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Streptolydigin, and which of those have an active Phase 3 trial?

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