Tagetitoxin

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DB04788ExperimentalSmall molecule

Tagetitoxin is a bacterial phytotoxin. It preferentially inhibits eukaryotic RNA polymerase.

Mechanism: Tagetitoxin inhibits all RNAP catalytic reactions. Tagetitoxin binding is mediated exclusively through polar interactions with the beta and beta' residues whose substitutions confer resistance to tagetitoxin in vitro.
Curator reviewed
Formula / weight: C₁₁H₁₇N₂O₁₁PS · 416.298 g/mol (avg)

Resolves to

Compound

CAS87913-21-1PubChem5327077

Structure

InChIKeyUVAAUIDYGIWLMB-HGNFPZBQSA-NSMILES[H]N([H])[C@H]1[C@@H](OC(C)=O)[C@@]2([H])O[C@](CS[C@@]2(O)C(=O)N([H])[H])([C@@H]1OP(O)(O)=O)C(O)=O

Targets

Q8RQE9rpoBQ8RQE8rpoC

What you can answer from here — as of April 02, 2025

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

6+ReferencesStructured and connected to the statements they support

Which drugs share a target with Tagetitoxin, and which of those have an active Phase 3 trial?

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